Comparison of Thinprep (Liquid-Based Cytology) and Conventional Cytology : Abnormal Lesion on Bronchoscopy

Background: The preparation of conventional smears (CS) from mucoid samples, despite mucolysis, can pose difficulties for cytotechnologists or cytopathologists. In recent years, liquid-based cytology (LBC) devices have been developed in attempts to improve the cytopreparation process. LBC improves both sample collection and sample preparation. Cell block preparations (CB) can be made from residual tissue fluids, and are a useful adjunct to smears. Methods: We retrospectively reviewed 3 preparations from 209 patients whose diagnosis was later confirmed via bronchoscopic biopsy, fine needle aspiration, gun biopsy or operation. Each case was categorized into one of three groups: "negative," "atypical or suspicious" and "malignant." Results: When conflating the "atypical" and "malignant" categories into a "positive" category, the sensitivity of each preparation was 74.4% in LBC, 72.9% in CS, and 76.5% in CB preparations. Specificity was 98.7%, 94.7% and 98.7%, respectively. By combining LBC and CB, the sensitivity is 78.2%. Conclusions: Among three different preparation methods, sensitivity is highest in the CB method. LBC has many advantages in evaluating cell morphology and by combining CB method, the sensitivity can be improved slightly. The application of all three methods may prove helpful when one or another method proves diagnostically inconclusive.

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Comparison of ThinPrep Cytology and Conventional Cytology in Bronchial Washing for Lung Cancer

Cho

Chung

et al. 2012

J Lung Cancer

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Purpose: Liquid-based cytology have been developed and currently used to overcome the limitation of conventional cytology. This study aims to evaluate the differences between conventional cytology and ThinPrep Ⓡ in the bronchial washing. Materials and Methods: Both conventional cytology and ThinPrep Ⓡ were performed in the 2,551 cases of bronchial washing, of which, 116 cases of histologically diagnosed as lung cancer were evaluated. Results: Among the 116 cases, 23 and 4 cases were negative in conventional cytology and ThinPrep Ⓡ , respectively. The thirty eight cases in conventional cytology and 30 cases in ThinPrep Ⓡ were diagnosed as "atypical." Malignant carcinoma was 54 cases and 82 cases in conventional cytology and ThinPrep Ⓡ , respectively. The positive predictive value, negative predictive value, sensitivity and specificity were 98.94%, 99.06%, 80.17%, and 99.96%, respectively in conventional cytology. Those were 99.12%, 99.83%, 96.55% and 99.96%, respectively in ThinPrep Ⓡ . Conclusion: ThinPrep Ⓡ (liquid-based cytology) revealed higher sensitivity and lower false negative rate than conventional cytology. ThinPrep Ⓡ has many advantages to diagnose the lung cancer from bronchial washing cytology. (J Lung Cancer 2012;11(2):84 88)

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Comparison of Thinprep (Liquid-Based Cytology) and Conventional Cytology : Abnormal Lesion on Bronchoscopy

Cited by 3 publications

References 15 publications

A Comparison of Conventional Cytology and ThinPrep Cytology of Bronchial Washing Fluid in the Diagnosis of Lung Cancer

A Comparison of Conventional Cytology and ThinPrep Cytology of Bronchial Washing Fluid in the Diagnosis of Lung Cancer

Comparison of Conventional Smear, Cell Block and Liquid-based Preparation in the Evaluation of Bronchial Washing Specimen in Lung Cancer Patients

Comparison of ThinPrep Cytology and Conventional Cytology in Bronchial Washing for Lung Cancer

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