Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis

Abstract

Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis Introduction: Denture stomatitis (DS) is the most common form of chronic oral candidiasis. The standard treatment for DS is nystatin, which is accompanied with complications such as a bitter taste. The aim of this study was to compare the effect of garlic with nystatin in DS. Material and Methods: This randomised clinical trial study was performed on 40 patients with DS. After obtaining written consent, patients were divided into two groups while members of each group were given either nystatin or garlic extract for 4 weeks. The length and width of erythema area was measured at the end of the first, second, third, and the fourth weeks using a calliper. Data were analysed by SPSS and statistical tests including variance analysis with ANOVA repeated measures, chi-square, and least square differences. Results: The changes in the length and width of erythema at different times according to the type of treatment were found to be significant while an accelerated recovery was demonstrated for nystatin (p < 0.001). Both regimens resulted in significant recovery (p < 0.0001). Greater satisfaction with the use of garlic rather than nystatin was mentioned (p < 0.0001). Conclusion: Considering the efficacy of garlic and lack of side effects for this compound and also regarding the nystatin-associated complications, garlic extract can be introduced as a substitution for standard treatment in DS.

<i>In vivo</i> study of antifungal effects of low-molecular-weight chitosan against <i>Candida albicans </i>

“…Although these agents exhibit therapeutic efficacy, their side effects limit their usage. Some of the most common side effects are bitter taste, localized allergic reactions following application, nausea and vomiting, possible adrenal insufficiency, and hepatic necrosis (9,23).…”

“…A participant should have type 2 denture stomatitis, should have worn dentures for at least 6 months, and should not have a systemic disease that compromises the immune system such as diabetes. Participants should not have any disorder that causes muscle weakness, such as Parkinson's disease, or that limits cognitive functioning, such as dementia or psychosis (23). Patients should not have a history of use of antifungals, antibiotics, or drugs that reduce saliva production (23).…”

“…Participants should not have any disorder that causes muscle weakness, such as Parkinson's disease, or that limits cognitive functioning, such as dementia or psychosis (23). Patients should not have a history of use of antifungals, antibiotics, or drugs that reduce saliva production (23). Patients were informed of the purpose and course of the study, and they signed written consent forms before participation in the study.…”

Activity of preparations from Spilanthes oleracea, propolis, Nigella sativa, and black garlic on different microorganisms involved in oral diseases and on total human salivary bacteria: A pilot study

“…The time-kill assay revealed that aqueous garlic extract showed better antiproteolytic effects on total Porphyromonas gingivalis protease activity compared with ethanolic garlic extract (Shetty, Thomas, Shetty, Bhandary, & Shetty, 2013 Lavage with lipophilic allicin combined with vancomycin inhibited biofilm formation by S. epidermidis in a rabbit model of prosthetic joint infection (Zhai, Pan, Pang, & Bai, 2014). In a pilot study of patients with denture stomatitis, a mouthwash with garlic aqueous extract was superior to nystatin primarily due to less adverse effects (Bakhshi, Taheri, Shabestari, Tanik, & Pahlevan, 2012). In a clinical pilot study done over a 7-day period, a mouthwash containing garlic extract was superior to the negative control but inferior to 0.2% CHX in reducing salivary S. mutans count, one of the primary etiological organisms known to cause dental caries (Chavan, Shetty, & Kanuri, 2010).…”

The role of candida albicans on the development of stomatitis in patients wearing dentures

“…It is also considered that garlic in combination with nystatin may be highly effective in the treatment of oral candidiasis, in particular those associated with denture stomatitis (9,47 …”