1983
DOI: 10.1016/s0262-1746(83)80010-9
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Comparison of the vasodepressor action of ZK 36 374, a stable prostacyclin derivative, PGI2 and PGE1 with their effect on platelet aggregation and bleeding time in rats

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Cited by 39 publications
(8 citation statements)
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“…26,27 Furthermore, human SMCs are known to express IP-receptors and a variety of EP receptors. 28 Accordingly, mRNA transcripts of the IP, EP 1 , EP 2 , EP 3 , and EP 4 receptors were detected by RT-PCR in SMCs from the mammary artery that were used in the present study (not shown).…”
Section: Iloprost Induces Has2 Via Stimulation Of Ip Receptorsmentioning
confidence: 99%
“…26,27 Furthermore, human SMCs are known to express IP-receptors and a variety of EP receptors. 28 Accordingly, mRNA transcripts of the IP, EP 1 , EP 2 , EP 3 , and EP 4 receptors were detected by RT-PCR in SMCs from the mammary artery that were used in the present study (not shown).…”
Section: Iloprost Induces Has2 Via Stimulation Of Ip Receptorsmentioning
confidence: 99%
“…The bullock iris sphincter preparation contains a PGE-sensitive contractile system which is blocked by SC 19220 (Posner, 1973). Our recent studies (Dong & Jones, 1982) have revealed that iloprost, a stable and potent mimetic of PGI2 (Casals-Stenzel et al, 1983) (Figure 1), possesses remarkably high agonist activity on the iris preparation and appears to behave as a partial agonist at the PGE receptor. We have investigated the action of iloprost on several other PGE sensitive preparations and also examined two other potent PGI2 mimetics, 6a-carba-A6'1PGI1 (Shibasaki et al, 1983) and ZK 96480 (Mueller et al, 1984) ( Figure 1).…”
Section: Introductionmentioning
confidence: 99%
“…In the experimental animal, Iloprost (ZK 36 374), a chemically stable carboprostacyclin derivative, was shown to be more potent than PGI2 with respect to antiplatelet properties, and it in duced less vasodilation [8,9]. Also, studies in which human platelets were incubated with ZK 36 374 de monstrated that the drug may be an even more power ful antiaggregating agent than PGI2 [8,10,11]. Fur ther, in human whole blood aggregation studies, ZK 36 374 caused disaggregation of preformed platelet aggregates [12].…”
Section: Discussionmentioning
confidence: 99%