Comparison of the treatment results of involved-field and elective nodal irradiation in locally advanced esophageal cancer

Park, Jeong Hoon; Kim, Woo Chul; Kim, Hun Jung

doi:10.1007/s10388-016-0545-5

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…Five studies ( 33 , 37 , 40 , 41 , 44 ) analyzed grade ≥3 late esophagitis (LE) ( Figure 3E ), including two RCTs ( 41 , 44 ) and three non-RCTs ( 33 , 37 , 40 ). No differences were observed (pooled RR, 0.92; 95% CI, 0.47–1.80; P= 0.81; high certainty).…”

Section: Resultsmentioning

confidence: 99%

“…No differences were observed (pooled RR, 0.92; 95% CI, 0.47–1.80; P= 0.81; high certainty). Furthermore, five studies ( 33 , 37 , 40 , 41 , 44 ) analyzed grade ≥3 late pneumonia (LP) ( Figure 3F ), including two RCTs ( 41 , 44 ) and three non-RCTs ( 33 , 37 , 40 ), and no differences were observed (pooled RR, 0.78; 95% CI, 0.42–1.42; P = 0.41; high certainty).…”

Section: Resultsmentioning

confidence: 99%

“…Totally, 12 ( 22 , 24 – 26 , 28 , 29 , 31 – 33 , 36 , 38 , 43 ), 11 ( 24 – 26 , 28 , 29 , 31 – 33 , 36 , 38 , 43 ), 12 ( 22 , 24 – 26 , 28 , 29 , 31 – 33 , 36 , 38 , 43 ), and 12 ( 22 , 24 – 29 , 31 , 32 , 36 , 38 , 42 ) studies were to analyze 1-, 2-, 3-, and 5-years PFS rates. IFI group had an advantage over ENI at 1-, and 3-year PFS rates (1-year PFS: pooled RR, 0.90; 95% CI, 0.85–0.95; P = 0.0004; high certainty; Figure 4A ; 3-year PFS: pooled RR, 0.86; 95% CI, 0.78–0.96; P = 0.007; moderate certainty; Figure 4C ).…”

Section: Resultsmentioning

confidence: 99%

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The role of involved field irradiation versus elective nodal irradiation in definitive radiotherapy or chemoradiotherapy for esophageal cancer- a systematic review and meta-analysis

Wang

Song²,

Zhao³

et al. 2022

Front. Oncol.

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ObjectiveThis study aimed to analyze whether involved field irradiation (IFI) is associated with improving survival outcomes and reducing adverse events compared with elective nodal irradiation (ENI) in patients of esophageal cancer who underwent definitive radiotherapy or chemoradiotherapy.Summary background dataRadiotherapy plays an important role for not surgery patients. However, the role of radiation target size is still uncertain.MethodsWe searched Web of Science, Embase, PubMed, and Cochrane Central for English and non-English publications comparing esophageal cancer patients who received radiotherapy with IFI with those with ENI. Primary outcomes included overall survival (OS) and adverse events related to radiotherapy. The risk of bias was assessed using the Cochrane Risk of Bias tool for randomized studies and the Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality Standard for non-randomized studies. We evaluated the certainty of evidence by Grading of Recommendations, Assessment, Development, and Evaluation.ResultsTotally, 23 studies with 4120 patients were included. IFI group demonstrated significant improvement in the OS rates at 5 years, but not at 1, 2, and 3 years, compared with the ENI group (pooled Risk Ratio [RR], 0.78; 95% confidence interval [CI], 0.68–0.90; P = 0.0004; high certainty). In addition, IFI demonstrated a significant decrease in the incidence of grade ≥2 acute esophagitis (AE) (pooled RR, 0.79; 95% CI, 0.69–0.90; P = 0.0005; high certainty) and grade ≥3 AE (pooled RR, 0.51; 95% CI, 0.38–0.69; P < 0.00001; high certainty) compared with ENI, but not in the incidence of grades ≥3 acute pneumonia, late esophagitis, and late pneumonia.ConclusionsCompared to ENI, IFI demonstrated significant improvement in OS at 5 years. The addition of intensity-modulated radiotherapy (IMRT) to IFI increased the 5-year OS; however, similar results were not observed with the addition of three-dimensional conformal radiotherapy to IFI and ENI. Furthermore, IFI demonstrated a significant decrease in grade ≥2 and grade ≥3 AE, while IMRT demonstrated no difference in the incidence of grade ≥3 AE. IFI and ENI do not differ in the incidence of grades ≥3 acute pneumonia, late esophagitis, and late pneumonia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The role of involved field irradiation versus elective nodal irradiation in definitive radiotherapy or chemoradiotherapy for esophageal cancer- a systematic review and meta-analysis

Wang

Song²,

Zhao³

et al. 2022

Front. Oncol.

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What Is the Optimal Radiotherapy Target Size for Non-Operable Esophageal Cancer? A Meta-Analysis

et al. 2019

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Definitive radiotherapy has an affirmative role in treating non-operable esophageal cancer; however, the controversy between elective lymph node irradiation (ENI) and involved-field irradiation (IFI) still remains. To ascertain the benefits and disadvantages of the two radiation target volumes, we performed a meta-analysis with 7 related publications. According to our findings, patients treated with ENI and IFI had nearly identical 1, 2, and 3-year survival rates (pooled odds ratio [OR] = 1.004, p = 0.980, and pooled OR = 1.15, p = 0.594, and pooled OR = 0.918, p = 0.679, respectively). Likewise, no significant differences were detected in local recurrence rates (pooled OR = 1.04, p = 0.883), regional recurrence rates (pooled OR = 0.65, p = 0.555), and distant metastasis rates (pooled OR = 1.29, p = 0.309) between the two treatment groups. However, IFI could significantly decrease the incidences of acute radiation esophagitis (pooled OR = 2.30, p = 0.001) and late pneumonia (pooled OR = 2.52, p = 0.04) compared with ENI. This meta-analysis provides evidence that IFI is more feasible for non-operable esophageal cancer than ENI.

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Comparison of the treatment results of involved-field and elective nodal irradiation in locally advanced esophageal cancer

Cited by 2 publications

References 22 publications

The role of involved field irradiation versus elective nodal irradiation in definitive radiotherapy or chemoradiotherapy for esophageal cancer- a systematic review and meta-analysis

The role of involved field irradiation versus elective nodal irradiation in definitive radiotherapy or chemoradiotherapy for esophageal cancer- a systematic review and meta-analysis

What Is the Optimal Radiotherapy Target Size for Non-Operable Esophageal Cancer? A Meta-Analysis

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