Comparison of the Therapeutic Efficacy of Surgery with or without Adjuvant Radiotherapy versus Radiotherapy Alone for Metastatic Spinal Cord Compression: A Meta-Analysis

Chen, Bin; Xiao, Shengxiang; Xiang, Tong; Xu, Sanzhong; Lin, Xiang

doi:10.1016/j.wneu.2014.12.039

Cited by 17 publications

(10 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondly, it is much safer to use RFA when mobilizing the spine, while resection may lead to bleeding problems. These findings, together with previous evidence, strongly support that RFA is an appealing complementary treatment for vertebrectomy [ 1 , 14 , 31 ].…”

Section: Discussionsupporting

confidence: 81%

“…For the arterial system and the valveless venous plexus of Batson, 36–55% of patients with primary cancers such as breast cancer, lung cancer, prostate cancer, renal cancer, thyroid cancer, gastrointestinal cancer, or multiple myeloma develop spine diseases, resulting in spinal column involvement or intramedullary spinal cord metastases [ 1 – 4 ]. Patients with metastatic spinal tumors usually show symptoms of bone pain, spinal cord compression, pathologic fracture, hypercalcemia, and progressive deformity.…”

Section: Introductionmentioning

confidence: 99%

“…Tomita et al [ 21 ] originally proposed that total en-bloc spondylectomy (TES) to achieve oncological complete tumor resection was generally not recommended for multiple spinal metastatic lesions. In this case, radiotherapy was considered as the primary treatment for multiple spinal metastases in the absence of an acute neurological deficit [ 1 ]. In fact, palliative surgery (decompression) is often performed for multiple spinal metastases to alleviate symptom [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Retrospective Evaluation of Operative and Postoperative Outcomes in Patients with Spinal Metastases from a Single Center to Compare Vertebrectomy with Combined Vertebrectomy and Radiofrequency Ablation

Han

Zhang

et al. 2021

Med Sci Monit

View full text Add to dashboard Cite

Background This retrospective study was conducted at a single center and aimed to evaluate operative and postoperative outcomes in patients with spinal metastases using vertebrectomy and combined vertebrectomy and radiofrequency ablation (RFA). Material/Methods Patients diagnosed with spinal metastases between April 2009 and March 2016 (n=49) included patients who underwent vertebrectomy (n=26) and patients who underwent combined vertebrectomy and RFA (n=23). The characteristics of the 2 groups were similar in primary tumor types, comorbidities, Tomita score, vertebral involvement, preoperative bone pain, and neurologic deficit. Results The results showed for the both groups that the visual analog scale (VAS) pain score was significantly decreased ( P <0.05) and the neurological status was improved after treatment. Compared with the control group (vertebrectomy only), the combination group (combined vertebrectomy and RFA) had less intraoperative blood loss ( P =0.002) and shorter operation time ( P <0.001). The recurrence rate was lower ( P =0.003) in the patients who received combined treatment, and the period of local recurrence was prolonged ( P =0.030) in the combination group. Conclusions This retrospective study showed that the selective use of combined vertebrectomy and RFA significantly reduced surgical time and blood loss, improved recovery of neurologic deficit, and reduced the tumor recurrence rate in patients with spinal metastases.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Retrospective Evaluation of Operative and Postoperative Outcomes in Patients with Spinal Metastases from a Single Center to Compare Vertebrectomy with Combined Vertebrectomy and Radiofrequency Ablation

Han

Zhang

et al. 2021

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…Surgery for spinal metastases is effective in the management of patients with cancer when their quality of life is threatened by pathological vertebral fracture or spinal cord compression. [1][2][3][4][5] Evolution of spinal surgery techniques over the past two decades have enabled direct spinal cord or nerve root decompression and tumor resection in combination with tailored spine reconstruction. Hence, the goal of surgery is to reduce pain and to restore or safeguard neurological function.…”

Section: Introductionmentioning

confidence: 99%

Loss of Local Tumor Control After Index Surgery for Spinal Metastases: A Prospective Cohort Study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Radiotherapy (RT) and surgery are 2 major options for MSCC. A meta-analysis 4 showed that surgery was superior to RT with regard to survival rates and motor function outcome. However, surgery is limited to a minority of patients because of strict patient selection.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Short-Course Radiotherapy Versus Long-Course Radiotherapy for Treatment of Metastatic Spinal Cord Compression

Meng

Liang

et al. 2015

Medicine

View full text Add to dashboard Cite

In this study, we evaluate the efficacy of short-course radiotherapy (SCRT) versus long-course radiotherapy (LCRT) in the treatment of metastatic spinal cord compression (MSCC).PubMed, EMBASE, and Web of Science were searched up to April 2015. Relevant data were extracted based on inclusion and exclusion criteria. Methodological quality of randomized controlled trial (RCT) was evaluated using modified Jadad scale; non-RCT was evaluated using Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.3 software.Fourteen studies with 2239 patients were included. Results of meta-analysis showed that there were no significant differences between SCRT and long-course radiotherapy LCRT in 6-month overall survival rate (risk ratio [RR] = 0.97, 95% confidence interval [CI] 0.88, 1.07, P = 0.55), 1-year overall survival rate (RR = 0.94, 95% CI 0.85, 1.04, P = 0.22), motor function improvement (RR = 0.96, 95% CI 0.81, 1.13, P = 0.63), no change on motor function (RR = 0.98, 95% CI (0.88, 1.09), P = 0.74], and deterioration on motor function (RR = 0.96, 95% CI 0.71, 1.31, P = 0.78). Compared with SCRT, LCRT significantly increased 6-month local control rate (RR = 0.87, 95% CI 0.80, 0.95, P = 0.002), 1-year local control rate (RR = 0.83, 95% CI 0.71, 0.97, P = 0.02), and 2-year local control rate (RR = 0.83, 95% CI 0.79, 0.87, P < 0.00001).Both LCRT and SCRT provided similar survival rates and functional outcome, but LCRT showed better local control rates than SCRT. However, considering low cost and good patient's compliance, SCRT may be a better choice.

show abstract

Comparison of the Therapeutic Efficacy of Surgery with or without Adjuvant Radiotherapy versus Radiotherapy Alone for Metastatic Spinal Cord Compression: A Meta-Analysis

Cited by 17 publications

References 27 publications

A Retrospective Evaluation of Operative and Postoperative Outcomes in Patients with Spinal Metastases from a Single Center to Compare Vertebrectomy with Combined Vertebrectomy and Radiofrequency Ablation

A Retrospective Evaluation of Operative and Postoperative Outcomes in Patients with Spinal Metastases from a Single Center to Compare Vertebrectomy with Combined Vertebrectomy and Radiofrequency Ablation

Loss of Local Tumor Control After Index Surgery for Spinal Metastases: A Prospective Cohort Study

Comparison of Short-Course Radiotherapy Versus Long-Course Radiotherapy for Treatment of Metastatic Spinal Cord Compression

Contact Info

Product

Resources

About