Comparison of the therapeutic effects of diclofenac sodium, prednisolone and an alpha blocker for the treatment of renal colic

Abstract

Objective: In this study, we compare the efficacy of diclofenac sodium, methylprednisolone and alphablockers for the treatment of renal colic treatment. Material and methods:A total of 30 patients between the ages of 18-70 were included in this study. Patients were referred to the

Alpha blockers in the management of ureteric lithiasis: A meta-analysis

“…Results of quality assessment using the Cochrane Risk of Bias tool can be found in Figure 7. Overall, a high degree of bias was seen with only nine studies judged to be at low risk while 41 were judged to be intermediate risk and 17 high risk . The most common cause for bias was blinding of both participants and personnel and outcomes assessment.…”

“…The majority of studies included only distal ureteric stones, however, 10 included proximal stones and four studies included mid ureteric stones. Six studies did not report stone position . While beneficial in distal and proximal stones, α‐blockers were more significantly more effective in treating distal ureteric stones (RR=1.50 [CI 1.38‐1.62], I 2 =51% P <.00001).…”

Therapeutic Approaches for Renal Colic in the Emergency Department: A Review Article

“…In the sympathetic nervous system, α-fibers are stimulants and β-adrenergic inhibitory ( 9 ), in addition, α-1 adrenergic receptors are available in the human ureter. These receptors, especially subgroup 1Dα, play roles in the dilatation of detrusor muscles and spasms of the distal third of the ureter ( 51 ). Blocking alpha-adrenergic receptors reduces spasms and pain, and in addition it induces ureteral stone removal ( 52 ).…”

“…In the group treated with adiclofenac and alpha-blocker combination, stone removal rates were higher in comparison with the other two groups. Alpha-blocker drugs are used more often in combination with antibiotics and oral corticosteroid therapy for medical expulsive therapy (MET) ( 51 ).…”

“…There is evidence that MET reduces the need for the administration of analgesia and accelerates the passage of ureteral stones with diameters less than 10 mm (similar size pieces of stone after shock wave lithotripsy (SWL)). Evidences suggest that MET could be considered as an effective treatment ( 51 ).…”