Comparison of the Systemic Lupus Erythematosus Activity Questionnaire and the Systemic Lupus Erythematosus Disease Activity Index in a Black Barbadian Population

Quimby, Kim R; Flower, Cindy; Hambleton, Ian; Landis, R. Clive; Hennis, Anselm

doi:10.1155/2013/875369

Cited by 10 publications

(8 citation statements)

References 11 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The measurement of disease activity in SLE is important to evaluate the outcome or severity of the disease. Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) is one instrument that often used to determine disease activity and has been widely accepted as a means to monitor SLE activity in clinical practice or for research (Quimby et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Urine Specific Proteins and Alpha-1 Antitrypsin Concentrations to Assess the Severity of Lupus Nephritis

Susianti¹,

Barlıanto²,

Hanggara³

et al. 2017

RJLS

View full text Add to dashboard Cite

Current biomarkers for evaluating disease activity or severity in lupus nephritis (LN) are considered to be unsatisfactory. Pathological changes in glomerular basement membrane and selectivity of electrical discharge are causing specific patterns of urine proteins excretion. Together with alpha-1 antitrypsin (AAT), they are expected to become new biomarkers to assess LN activity.Seventy-one urine samples were collected from healthy controls and LN patients. Patterns of urine specific proteins were determined using column chromatography and SDS-PAGE tests, LN activity was calculated using SLEDAI-renal domain score, and AAT concentrations was measured by ELISA.The majority of proteins in the control group have molecular weights of >66 kDa (88%) and 21-to 25-kDa proteins were observed only in the case group. The p values for differences in urine AAT concentration between active LN and healthy controls, inactive LN and healthy controls, and active LN and inactive LN were 0.004, 0.046, and 0.054, respectively, whereas those for urine AAT/creatinine ratio were 0.489, 0.019, and 0.915, respectively. There were differences in the patterns of the molecular weight of proteins and urine AAT concentrations between case group and control group. However, no such differences were identified between active and inactive LN.

show abstract

Section: Introductionmentioning

confidence: 99%

Urine Specific Proteins and Alpha-1 Antitrypsin Concentrations to Assess the Severity of Lupus Nephritis

Susianti¹,

Barlıanto²,

Hanggara³

et al. 2017

RJLS

View full text Add to dashboard Cite

show abstract

“…This scoring modality was used for the SRI (3). In one study (25), PGA of disease activity resulted from the combination of clinical visit, laboratory markers evaluation and physician’s knowledge of the patient disease history. In the absence of a consensus, Aranow (26) found a better correlation between the SLEDAI and the PGA when the latter was assessed taking into account laboratory test results.…”

Section: Resultsmentioning

confidence: 99%

“…Supporting the face validity property, PGA was defined “gold-standard” in 11 studies (2, 10-11, 21, 32, 49, 67, 76, 78, 84, 88) and in 32 it was used as the reference to which other activity scores were compared, such as the SLEDAI (4, 10, 13, 25, 27-28, 31, 33, 35-36, 41, 46-47, 50-51, 53, 62, 65, 68, 72-73, 76, 81, 96-99), BILAG (4, 27, 35-36, 46, 65, 72-73, 81, 98), SLAM (4, 72, 76, 99), LAI (68, 88), patient global assessment (ptGA) (81, 83-84) and ECLAM (35). However, it was used as a single outcome measure only in two studies (49, 100) whilst in the majority the PGA was scored together with another instrument (typically the SLEDAI) (2, 9, 11-12, 21, 24, 30, 32, 34, 37-40, 44-45, 48-49, 55, 58-59, 61, 63-64, 66-67, 74-75, 80, 82, 86, 89-95, 103).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Use of Physician Global Assessment (PGA) in Systemic lupus erythematosus: a systematic review of its psychometric properties

Chessa

Piga

Floris

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Methods: This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. All articles published until the 1st of July 2019 in Pubmed were screened with no limitation about years of publication, language or patients' age. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. Results: The literature search identified 91 studies. Face validity was reported in all the articles retrieved, in which the PGA was used alone or as part of composite indices (SRI, SFI, LLDAS, DORIS remission criteria). Content validity was reported in 89 studies. Construct validity was demonstrated by a good correlation between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarkers levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. A good responsiveness for PGA was shown in 8 studies. A high variability in scales was found, causing a wide range of reliability (ICC=0.67-0.98). Conclusion: PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring.

show abstract

“…Discrepancies in disease assessment between SLAQ and SLEDAI have been reported by others. 12,14 Indeed, despite significant overlapping between SLEDAI descriptors and SLAQ questions, the two instruments demonstrated low agreement when tested simultaneously. 12,14 Moreover, another explanation can rely on the fact that the timeframe for patient symptom recall varies significantly between the SLEDAI (that takes into account the previous 10 days) and the SLAQ (that covers a 3-month period).…”

Section: Discussionmentioning

confidence: 99%

Translation, cultural adaptation and validation of the Italian version of the Brief Index of Lupus Damage: the BILDit

Elefante

Tani

Santoni

et al. 2020

Lupus

View full text Add to dashboard Cite

Objectives The Brief Index of Lupus Damage (BILD) is an instrument of self-evaluation of organ damage for systemic lupus erythematosus (SLE) patients. The objectives of this study were the translation, cultural adaptation and validation of the Italian version of the BILD (BILDit). Methods The process of translation and cultural adaptation followed published guidelines. The BILDit was pretested in a pilot study with 30 SLE patients in order to evaluate acceptability, reliability, comprehension and feasibility, and then validated in consecutive SLE patients attending our clinic. Results A total of 167 SLE patients were enrolled. In the pilot study, the BILDit demonstrated good acceptability, feasibility and comprehensibility and a very high degree of reliability (Cronbach’s α = 1). In the validation cohort, the BILDit showed a significant positive correlation with the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI; ρ = 0.69; p < 0.001). Analysing the item-by-item correlation between the BILDit and the SDI, a good correlation ( p < 0.001) was found for 73.1% of the items. In the multivariate analysis, the BILDit showed a significant positive correlation with age and disease duration ( p < 0.01). Conclusions The BILDit seems to be an acceptable and reliable instrument for patient self-evaluation of disease damage, with a good correlation with the SDI. It can be considered as a screening tool for the evaluation of organ damage starting from the patient’s perceptive.

show abstract

Comparison of the Systemic Lupus Erythematosus Activity Questionnaire and the Systemic Lupus Erythematosus Disease Activity Index in a Black Barbadian Population

Cited by 10 publications

References 11 publications

Urine Specific Proteins and Alpha-1 Antitrypsin Concentrations to Assess the Severity of Lupus Nephritis

Urine Specific Proteins and Alpha-1 Antitrypsin Concentrations to Assess the Severity of Lupus Nephritis

Use of Physician Global Assessment (PGA) in Systemic lupus erythematosus: a systematic review of its psychometric properties

Translation, cultural adaptation and validation of the Italian version of the Brief Index of Lupus Damage: the BILDit

Contact Info

Product

Resources

About