Comparison of the specificity of human and bovine tuberculin PPF for testing cattle. 3. National trial in Great Britain

Lesslie, I.W.; Herbert, CN

doi:10.1136/vr.96.15.338

Cited by 34 publications

(23 citation statements)

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“…High specificities for the skin tests are also described in reviews [13][14][15], all citing a paper from Lesslie [33] published in 1975. The tuberculins used at that time might differ from those used nowadays due to efforts in standardization.…”

Section: Discussionmentioning

confidence: 99%

The Accuracy of the Single Intradermal Comparative Skin Test for the Diagnosis of Bovine Tuberculosis-Estimated from a Systematic Literature Search

Hartnack

Torgerson²

2012

Mycobact Dis

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Background: Bovine Tuberculosis (bTN) elimination programs are based on test-and-slaughter strategies. No diagnostic test used in the control of Bovine Tuberculosis (bTB), a zoonotic disease, is a perfect gold standard having a diagnostic sensitivity and specificity of 100%. Methods: To find relevant data to assess diagnostic accuracy of one variant of the tuberculin test, the Single Intradermal Comparative Cervical Tuberculin Test (SICCT) used in the diagnosis of bTB a systematic literature search was performed. To estimate diagnostic test accuracies of the SICCT, a Bayesian latent class analysis has been undertaken. Results: Only one eligible study was found. Assuming bacterial isolation has a specificity of 100%, specificity of gross lesion detection and histopathology were estimated as 90% and 97% respectively. Estimates of the sensitivity of the Single Intradermal Comparative Cervical Tuberculin Test (SICCT), gross lesion detection, histopathology and bacteriological isolation were 80%, 89%, 93% and 98% respectively. The design of this study precluded estimating the SICCT specificity, although official UK surveillance data indicates specificity greater than 99.67%. Conclusion: Studies to estimate the diagnostic performance of key tests for bTB are lacking, yet essential for an informed debate in regard to bTB public health policy.

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Section: Discussionmentioning

confidence: 99%

The Accuracy of the Single Intradermal Comparative Skin Test for the Diagnosis of Bovine Tuberculosis-Estimated from a Systematic Literature Search

Hartnack

Torgerson²

2012

Mycobact Dis

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“…The influence of environmental mycobacteria and non-specific responses on TST in the diagnosis of bovine TB have been widely reported (Philips et al 2003;Biet et al 2005;de la Rua-Domenech et al 2006a;Oloya et al 2006;OIE 2009). Indeed, Lesslie and Herbert (1975) and Lesslie et al (1975a, b), recorded hypersensitivity responses to AT that were equal to or higher than responses to BT in cattle naturally infected with M. bovis and presenting visible lesions at slaughter. The nature of the tuberculin is vital in non-specific skin test responses for the diagnosis of bovine TB, and the use of M. bovis-specific purified antigen as the test reagent is imperative for improved test performances (Pollock et al 2003;de la Rua-Domenech et al 2006a).…”

Section: Prevalence Of Bovine Tuberculosis Based On Tuberculin Skin Tmentioning

confidence: 99%

Prevalence of bovine tuberculosis in cattle in the highlands of Cameroon based on the detection of lesions in slaughtered cattle and tuberculin skin tests of live cattle

Awah-Ndukum¹,

Kudi²,

Bradley³

et al. 2012

Vet. Med. - Czech

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Bovine tuberculosis (TB) is an important neglected zoonosis in Cameroon, where many communities depend on their livestock for livelihood and the incidence of human TB and TB-HIV/AIDS co-infection are high and increasing annually. The aim of this study was to estimate the prevalence of bovine TB in cattle in the highlands of Cameroon. The magnitude and trend of detecting TB lesions in slaughtered cattle (1994 to 2010) and tuberculin skin tests (TST) in 2853 cattle (84 herds) of 39 livestock rearing communities were analysed. Of 129 165 slaughtered cattle inspected, 599 (0.46%; 95% CI: 0.43%-0.50%) showed suspected TB lesions among a total of 983 (0.76%; 95% CI: 0.71%-0.81%) identified pathologies. The monthly TB detection rates ranged from 0.30% (95% CI: 0.20%-0.40%) to 0.81% (95% CI: 0.64%-0.98%) and annual rates from 0.04% (95% CI: 0%-0.11%) to 1.46% (95% CI: 1.22%-1.69%). The rates were not affected (P < 0.05) by season and fluctuating peaks were also recorded. The comparative TST revealed that bovine TB was widely distributed in live cattle (4.67%; 95% CI: 3.89%-5.44%) and was higher (χ 2 = 17.50, P ≤ 0.001) in the Western highlands than Adamawa plateaux.Comparative TST bovine TB reactors were higher (P < 0.05) in cattle managed in semi-intensive and beef production systems compared to the others. Animals in small herds showed higher (χ 2 = 4.283, P = 0.038) rates than those in large herds. Bovine TB prevalence in exotic/upgraded cattle was comparable to that of the Red Bororo zebu but higher than the rates in Guadali (χ 2 = 4.971, P = 0.026) and White Fulani (χ 2 = 5.6, P = 0.018) zebus.Among the indigenous zebus, the rate was higher in Red Bororo than the Guadali (χ 2 = 6.244, P = 0.012) and White Fulani (χ 2 = 6.568, P = 0.010). Sex did not influence (χ 2 = 0.410, P = 0.522) bovine TB prevalence in this study but diagnosis of the disease was higher (χ 2 = 5.787; P = 0.016) among adult/older cattle than in younger animals. Further analysis of the TST responses revealed that atypical mycobacterial infections was widespread and 6.83% of tested animals showed positive reactions at both bovine and avian tuberculin injection sites and a strong association (χ 2 = 2.512; P = 0.113) between skin responses to both tuberculins. The study confirms that bovine TB is prevalent in live cattle and meat production abattoirs in Cameroon and we recommend strict a interpretation of TST results for maximum diagnosis of the disease in the local environment. A need for comprehensive investigation of the molecular epidemiology, zoonotic risks and the public health importance of bovine TB in Cameroon cannot be overemphasised.

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“…For bTB diagnosis, the single comparative intradermal tuberculin skin test (SCITT) using purified protein derivative tuberculin (PPD, Bovituber, Synbiotics Corporation, France) was performed on cattle as described by Lesslie & Herbert [32]. Three days post-injection, skin fold thicknesses were re-measured using callipers and positivity assessed according to Shirima et al [33].…”

Section: Sample Processing and Storagementioning

confidence: 99%

Relationship between burden of infection in ungulate populations and wildlife/livestock interfaces

et al. 2013

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SUMMARYIn southern African transfrontier conservation areas (TFCAs), people, livestock and wildlife share space and resources in semi-arid landscapes. One consequence of the coexistence of wild and domestic herbivores is the risk of pathogen transmission. This risk threatens local livelihoods relying on animal production, public health in the case of zoonoses, national economies in the context of transboundary animal diseases, and the success of integrated conservation and development initiatives. The level of interaction between sympatric wild and domestic hosts, defining different wildlife/livestock interfaces, characterizes opportunities of pathogen transmission between host populations. Exploring the relationship between infection burden and different types of wildlife/ domestic interfaces is therefore necessary to manage the sanitary risk in animal populations through control options adapted to these multi-host systems. Here, we assessed the infection burdens of sympatric domestic cattle (Bos taurus/Bos indicus) and African buffalo (Syncerus caffer) at an unfenced interface and compared the infection burdens of cattle populations at different wildlife/ livestock interfaces in the Great Limpopo TFCA. Patterns of infection in ungulate populations varied between wild and domestic hosts and between cattle populations at different wildlife/livestock interfaces. Foot-and-mouth disease, Rift Valley fever and theileriosis infections were detected in buffalo and cattle at unfenced interfaces; bovine tuberculosis was only present in buffalo; and brucellosis and lumpy skin disease only in cattle. At unfenced interfaces, cattle populations presented significantly higher Theileria parva and brucellosis prevalence. We hypothesize that cattle populations at wildlife/livestock interfaces face an increased risk of infection compared to those isolated from wildlife, and that the type of interface could influence the diversity and quantity of pathogens shared. Additional host behavioural and molecular epidemiological studies need to be conducted to support this hypothesis. If it is confirmed, the management of wildlife/livestock interfaces will need to be considered through the prism of livestock and public health.

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Comparison of the specificity of human and bovine tuberculin PPF for testing cattle. 3. National trial in Great Britain

Cited by 34 publications

References 0 publications

The Accuracy of the Single Intradermal Comparative Skin Test for the Diagnosis of Bovine Tuberculosis-Estimated from a Systematic Literature Search

The Accuracy of the Single Intradermal Comparative Skin Test for the Diagnosis of Bovine Tuberculosis-Estimated from a Systematic Literature Search

Prevalence of bovine tuberculosis in cattle in the highlands of Cameroon based on the detection of lesions in slaughtered cattle and tuberculin skin tests of live cattle

Relationship between burden of infection in ungulate populations and wildlife/livestock interfaces

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