Comparison of the severity of atopic dermatitis lesions and the density of Staphylococcus aureus on the lesions after antistaphylococcal treatment

Akiyama, Hisanori; Toi, Yôichiro; Kanzaki, Hiromitsu; Tada, Jôji; Arata, Jirô

doi:10.1007/bf02350843

Cited by 27 publications

(32 citation statements)

References 14 publications

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“…RT-PCR analysis of the kinetics of RANTES mRNA expression relative to G3PDH in cultured human keratinocytes with or without stimulation. In contrast, not only eczematous but normal-appearing skin in almost all patients with AD is colonized with S. aureus in higher prevalence and density than in normal skin of healthy subjects or other types of eczematous skin [1][2][3][4][5][20][21][22][23]. Area of RANTES/ G3PDH expression was calculated as described in Material and methods.…”

Section: Discussionmentioning

confidence: 99%

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Possible influences of Staphylococcus aureus on atopic dermatitis — the colonizing features and the effects of staphylococcal enterotoxins

Morishita

Tada

Sato

et al. 1999

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

“…Heavy colonization with S. aureus of AD lesions is well documented [1][2][3][4][5]. The clinical course of AD is influenced by a number of environmental factors including colonization of the skin with Staphylococcus aureus.…”

Section: Introductionmentioning

confidence: 99%

Possible influences of Staphylococcus aureus on atopic dermatitis — the colonizing features and the effects of staphylococcal enterotoxins

Morishita

Tada

Sato

et al. 1999

Clin Experimental Allergy

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“…However, little is known about the precise protective role of C16:1Δ6 against the growth of S. aureus in healthy human skin because a selective depletion of C16:1Δ6 from sebum has not been experimentally attainable. Because of the high susceptibility of AD skin to colonization by S. aureus [7], it would be intriguing to determine whether the content of freeC16:1Δ6 in SSL and/or the composition of esterified fatty acids in sebum is significantly lower in AD skin compared with healthy control skin. In this connection, Yamamoto et al [8].…”

Section: Introductionmentioning

confidence: 99%

Deficient Production of Hexadecenoic Acid in the Skin Is Associated in Part with the Vulnerability of Atopic Dermatitis Patients to Colonization by <i>Staphylococcus aureus</i>

Takigawa

Nakagawa²,

Kuzukawa³

et al. 2005

Dermatology

117

107

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Background and Objectives: As one of the major skin fatty acids, cis-6-hexadecenoic acid (C16:1Δ6) exhibits a specific antibacterial activity and might play a specific role in the defense mechanism against Staphylococcus aureus, in healthy subjects whereas S. aureus frequently colonizes the skin of patients with atopic dermatitis (AD). Methods: Fatty acid composition of sebum at the recovery level was analyzed by gas chromatography and S. aureus colonizing the skin was assessed by the ‘cup-scrub’ method (9 patients and 10 healthy controls). To evaluate in vivo effect of C16:1Δ6 on colonization, C16:1Δ6 was applied for 2 weeks on the upper arm skin of another group of AD patients (11 patients). Results: Analysis of sebum lipids revealed that there is a significant lower free C16:1Δ6 content in nonlesional skin from AD patients compared with healthy controls. This lower content is also accompanied by a significantly lower level of C16:1Δ6 in the total fatty acid composition of sebum (analyzed following hydrolysis). The lower level of free C16:1Δ6 correlated significantly (R² = 0.41, p < 0.01) with the numbers of S. aureus colonizing nonlesional skin. Topical application of free C16:1Δ6 on the skin of AD patients for 2 weeks abolished the markedly increased bacterial count in 6 out of the 8 AD patients tested. Conclusions: Free C16:1Δ6 may be involved in the defense mechanism against S. aureus in healthy skin and this deficit triggers the susceptibility of the skin to colonization by S. aureus in AD.

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“…One of the possible reasons for this is the relatively higher sensitivity of MSSA to antibiotics compared with MRSA infection. Akiyama et al 11 reported the efficacy of cefdinir in treating erythema in atopic dermatitis infected by MSSA. In accordance with these clinical finding, the erythroderm-like disorder in the present patient was rapidly ameliorated after the use of cefdinir followed by cefazolin.…”

Section: Discussionmentioning

confidence: 98%

Glomerulonephritis induced by methicillin-sensitive Staphylococcus aureus infection

Handa

Ono

Watanabe

et al. 2003

Clinical and Experimental Nephrology

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A 57-year-old woman developed exacerbation of atopic dermatitis, fever, and nephrotic syndrome with microscopic hematuria. By bacteriological study, methicillin-sensitive Staphylococcus aureus (MSSA) was detected from each culture of pharyngeal mucus, stool, and blood samples. Renal biopsy specimens showed endocapillary proliferative glomerulonephritis with massive IgA deposition in the mesangium and along the capillary loops. After antistaphylococcal therapy with antibiotics, MSSA was negative for each culture and urinary protein decreased. Nine months after the first renal biopsy, a re-biopsy was performed, which revealed apparent disappearance of both endocapillary cell proliferation and IgA deposition. It is known that methicillin-resistant S. aureus (MRSA) infection causes glomerulonephritis through T-cell stimulation by superantigen presented by MRSA. The present results suggest that not only MRSA but also MSSA can cause this type of glomerulonephritis.

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Comparison of the severity of atopic dermatitis lesions and the density of Staphylococcus aureus on the lesions after antistaphylococcal treatment

Cited by 27 publications

References 14 publications

Possible influences of Staphylococcus aureus on atopic dermatitis — the colonizing features and the effects of staphylococcal enterotoxins

Possible influences of Staphylococcus aureus on atopic dermatitis — the colonizing features and the effects of staphylococcal enterotoxins

Deficient Production of Hexadecenoic Acid in the Skin Is Associated in Part with the Vulnerability of Atopic Dermatitis Patients to Colonization by <i>Staphylococcus aureus</i>

Glomerulonephritis induced by methicillin-sensitive Staphylococcus aureus infection

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