Comparison of the Serum Immunoglobulin IgM Level in Diabetic and Nondiabetic Patients with Chronic Periodontitis

Kranthi, J; Sudhakar, K.; Kulshrestha, Reena; Pk, Raju; Razdan, Ajay; Ts, Srinivasa

doi:10.5005/jp-journals-10024-1408

Cited by 3 publications

(2 citation statements)

References 17 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunoglobulins G, A, and M have been reported to be present in statistically signifi cant higher levels in long-lasting (months of) poor control diabetic patients compared to healthy controls. 24,25 The observations of the present study conclude the possible relationship associated with increased rate of tissue destruction in diabetic patients with periodontitis. The present study indicates that poor glycemic control may be associated with the increase in serum antibodies.…”

Section: Discussionsupporting

confidence: 66%

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Chaurasia

Kulshrestha²,

Pooja

et al. 2014

Asian J Med Sci

View full text Add to dashboard Cite

Objective: Diabetics are more susceptible to the infections than the non-diabetics (healthy) one, suggesting that the immunologic capability may be unbalanced in diabetics. Periodontitis is associated with alterations in immune responses in both diabetic and non-diabetic subjects. Till date various attempts has been taken to monitor host immunological response of diabetic individuals. Therefore the need to study the local immune response in infl amed gingival showing Periodontitis is apparent. Since till date there are no well documented and signifi cant baseline studies are available on the functional capacities of the lymphoid cells present in gingiva of the periodontitis patients, a study to check the level of immunoglobulin was investigated. Methodology: A study was carried out where HbA1c, Random Blood Sugar and Serum IgA level were assessed in 60 patients from the OPD of RCDSR. 15 patients each belonging to the four groups diabetic with periodontitis, diabetic without periodontitis, nondiabetic with periodontitis and non-diabetic without periodontitis (control) were analysed for the quantitative estimation of Serum Immunoglobulin A by Turbidometric Immunoassay and HbA1c was done by using Nyco card Reader. Result: The data thus obtained were compared with the level of immunoglobulin found in clinically healthy gingival of the control group. The levels of IgA were found to be high in group 'A' (Diabetic patients suffering from Periodontitis) group 'B' (Diabetic patients not suffering from Periodontitis) and group 'C' (Non-diabetic patients suffering from Periodontitis) but the values are not differing statistically from each other. But, the values of all these groups are statistically highly differed from the value obtained against the normal/healthy controlled group 'D'. Conclusion: In our study it can be concluded that there was positive co-relation between the two parameters: elevated HbA1c and Immunoglobulin level with periodontitis. This co-relates to the possibility of an underlying immuno-infl ammatory abnormality to be the cause for the elevated level of immunoglobulin in our patients with elevated sugar level.

show abstract

Section: Discussionsupporting

confidence: 66%

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Chaurasia

Kulshrestha²,

Pooja

et al. 2014

Asian J Med Sci

View full text Add to dashboard Cite

show abstract

“…It is well known that bacterial infection is the main cause of periodontal disease, and the bacterial colonization of actinomycetes and Porphyromonas gingivalis is the main cause of periodontitis[9,10]. On the one hand, the change of immune response in diabetic patients may cause periodontitis[11]. On the other hand, the severity of periodontal disease may also be related to the expression of multiple metalloproteinase genes in the oral mucosal epithelium[12].…”

Section: Introductionmentioning

confidence: 99%

Study on gene expression patterns and functional pathways of peripheral blood monocytes reveals potential molecular mechanism of surgical treatment for periodontitis

José

Liu

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUND Periodontitis is a chronic inflammation of periodontal supporting tissue caused by local factors. Periodontal surgery can change the gene expression of peripheral blood mononuclear cells. However, little is known about the potential mechanism of surgical treatment for periodontitis. AIM To explore the potential molecular mechanism of surgical treatment for periodontitis. METHODS First, based on the expression profiles of genes related to surgical treatment for periodontitis, a set of expression disorder modules related to surgical treatment for periodontitis were obtained by enrichment analysis. Subsequently, based on crosstalk analysis, we proved that there was a significant crosstalk relationship between module 3 and module 5. Finally, based on predictive analysis of multidimensional regulators, we identified a series of regulatory factors, such as endogenous genes, non-coding RNAs (ncRNAs), and transcription factors, which have potential regulatory effects on periodontitis. RESULTS A total of 337 genes related to surgical treatment for periodontitis were obtained, and 3896 genes related to periodontitis were amplified. Eight expression modules of periodontitis were obtained, involving the aggregation of 2672 gene modules. These modules are mainly involved in G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, and adenylate cyclase-modulating G-protein coupled receptor signaling pathway. In addition, eight endogenous genes (including EGF , RPS27A , and GNB3 ) were screened by network connectivity analysis. Finally, based on this set of potential dysfunction modules, 94 transcription factors (including NFKB1, SP1, and STAT3) and 1198 ncRNAs (including MALAT1, CRNDE, and ANCR) were revealed. These core regulators are thought to be involved in the potential molecular mechanism of periodontitis after surgical treatment. CONCLUSION Based on the results of this study, we can show biologists and pharmacists a new idea to reveal the potential molecular mechanism of surgical treatment for periodontitis, and provide valuable reference for follow-up treatment programs.

show abstract

Features of Changes in Indicators of Local Immunity of the Oral Cavity and Blood Serum of Patients Against the Background of Generalized Periodontitis and Type 2 Diabetes Mellitus

Balitska,

Hasiuk,

Piasetska

et al. 2023

UESMS

View full text Add to dashboard Cite

Aim: to evaluate the nature of changes in innate humoral immunity in oral fluid and blood serum in patients with generalized periodontitis against the background of type 2 diabetes mellitus and in their combination. Materials and methods. We examined 68 patients with a clinically established diagnosis of type 2 diabetes mellitus (of which 32 were additionally diagnosed with chronic generalized periodontitis), who were divided into 4 groups. The content of the main classes of immunoglobulins Ig A, Ig G and Ig M in blood serum and oral fluid was determined by radial immunodiffusion in a gel using monospecific antisera according to G. Manchini (Manchini G., 1965). Statistical processing of data was carried out using the Shapiro criterion. The level of statistical significance of differences between samples was assessed using the nonparametric Mann-Whitney test. Results. The lowest sIg A values and the highest Ig G values in the oral fluid were found in patients of group 4 with generalized periodontitis against the background of type 2 diabetes mellitus. A probable decrease in the level of sIg A was established, in particular, in the 2nd group by 1.27 times, the 3rd by 4.98 times and the 4th by 7.48 times in relation to the data of the control group (p<0, 01). The level of Ig G was probably higher in group 2 by 1.62 times, respectively, in group 3 – by 2.29 times and in group 4 – by 3.35 times, relative to control values (p<0.01 ). At the same time, when studying indicators in blood serum, the results of our studies indicate an imbalance of immunoglobulin fractions in the pathologies under study. Thus, the level of Ig A in the 2nd group was probably 1.7 times higher, in the 3rd group – 1.6 times higher, and in the 4th group – 2.0 times higher, relative to the data in the control group (p<0.001). The level of Ig M in the 2nd group was statistically significantly lower by 1.2 times, while in the 3rd and 4th groups it was probably higher by 1.7 and 1.2 times, respectively. The level of Ig G was probably higher in the 2nd and 3rd groups – by 1.3 times and in the 4th – by 2.0 times, relative to control values (p <0.05). This indicates that type 2 diabetes complicates the course of chronic periodontitis, as evidenced by changes in the concentrations of the main classes of immunoglobulins. Conclusions. Thus, generalized periodontitis against the background of type 2 diabetes mellitus is accompanied by significant changes in local immunity in biological fluids, as evidenced by disruption of the functioning of the humoral part of the adaptive immune system, which is manifested by an increase in the content of the main classes of immunoglobulins Ig A, Ig M, Ig A.

show abstract

Comparison of the Serum Immunoglobulin IgM Level in Diabetic and Nondiabetic Patients with Chronic Periodontitis

Cited by 3 publications

References 17 publications

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Study on gene expression patterns and functional pathways of peripheral blood monocytes reveals potential molecular mechanism of surgical treatment for periodontitis

Features of Changes in Indicators of Local Immunity of the Oral Cavity and Blood Serum of Patients Against the Background of Generalized Periodontitis and Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About