Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas

Steinberg, William M.; Gelfand, Richard; Anderson, Kimberly K.; Glenn, Jerry; Kurtzman, Scott H.; Sindelar, William F.; Toskes, Philip P.

doi:10.1016/0016-5085(86)90930-3

Cited by 196 publications

(89 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results were similar to previous reports (Kuusela et al, 1991;Nilsson et al, 1992;Pasanen et al, 1992) and superior to other studies (Banfi et al, 1993;Rothlin et al, 1993). Although (Schmigel et al, 1985;Tatsuta et al, 1985;Malesci et al, 1987;Kawa et al, 1990) and liver diseases (Jalanko et al, 1984;Steinberg et al, 1986;Kawa et al, 1990;Kobayashi et al, 1991) and false-negative results in cancer patients with Lewis-negative phenotype (Hirano et al. 1987;Margaret et al, 1987;Kawa et al, 1991).…”

Section: Mcssonsupporting

confidence: 91%

Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer

Kawa

Tokoo²,

Hasebe³

et al. 1994

Br J Cancer

View full text Add to dashboard Cite

SmryA comparative study of a new tumour marker, CA242, and CA19-9 was conducted with special reference to their diagnostic usefulness in pancreatic cancer. CA242 showed senstivity similar to that of the C241 catcher antibody of this assay system, which has alnost the same epitope specitity as the C50 and the NS19-9 monoclonal antibodies. In conusio, CA242 is superior to CA19-9 in diagning pancreatic cancer by virtue of its higher specificity.

show abstract

Section: Mcssonsupporting

confidence: 91%

Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer

Kawa

Tokoo²,

Hasebe³

et al. 1994

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…During the last 10 years it has been replaced by CA 19-9, which has a clearly higher sensitivity of 72-79% (Klapdor et al, 1984;Haglund et al, 1986;Steinberg et al, 1986;Benini et al, 1988). CA 19-9 is also sensitive in detecting recurrences of pancreatic cancer after operation for cure (Klapdor et al, 1984;Haglund et al, 1986Haglund et al, , 1989.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of preoperative serum levels of CA 19-9 and CEA in patients with pancreatic cancer

Lundin

Roberts²,

Kuusela³

et al. 1994

Br J Cancer

105

View full text Add to dashboard Cite

The prognostic value of preoperative serum levels of CA 19-9 and CEA was evaluated in 160 patients with pancreatic cancer. The survival of patients whose tumour marker value was below a certain cut-off level was compared with the survival of those with a higher value using the log-rank test. The lowest cut-off level dividing patients into groups with significant difference in survival (P < 0.05) was determined by graphical analysis of chi-square values at different cut-off levels. If stage of disease was not taken into account, there was a significant difference in survival between patients with low vs high preoperative CA 19-9 and CEA levels. When patients were classified according to stage, a difference was found for CA 19-9 in stage II-III patients. Patients with preoperative CA 19-9 below 370 U ml-1 had a significantly better prognosis than those with a higher level (P < 0.05). In stage I and stage IV patients, no significant difference was found between the groups at any cut-off level. The analysis of CEA showed a significant difference in survival only in stage IV patients, with CEA above 15 ng ml-1 being associated with shorter survival. In conclusion, in patients with stage II-III disease, particularly in patients with a non-resectable tumour, in whom the exact spread of the disease may be difficult to evaluate even at operation, the preoperative CA 19-9 level seems to have a prognostic value.

show abstract

“…The reason why five of the 28 patients with oesophagitis also had elevated levels of CA19-9 is uncertain. One possible explanation lies in the fact that monoclonal antibodies to CA19-9 react with a high molecular weight mucin antigen as well as a low molecular weight ganglioside (Steinberg et al, 1986) and that inflammation of the oesophagus may lead to an increased production of mucin by the oesophageal mucus-secreting glands. Antigens derived from the oesophageal mucus if present in the circulation, could then be recognised by the anti CA19-9 monoclonal antibodies.…”

Section: Discussionmentioning

confidence: 99%