Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S

Voits, Mechthild; Voigt, Jörg-Peter; Boomgaarden, M.; Henklein, Peter; Fink, Heidrun

doi:10.1016/0196-9781(95)02131-0

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…Studies on CCK-8 analogues indicated that Asp N-methylation is responsible for CCK-A receptor selectivity. The duration of the anorectic action of 58 in vivo was greater than that of CCK-8 …”

Section: Mechanisms Targeting the Gastrointestinal Tractmentioning

confidence: 90%

“…The duration of the anorectic action of 58 in vivo was greater than that of CCK-8. 177 Replacement of the methionine residue of Boc-CCK-4 (Boc-Trp-Met-Asp-Phe-NH 2 ) with side-chain-substituted Lys derivatives resulted in A 71623 (59). 178 This tetrapeptide is a potent and selective agonist at the CCK-A receptor and is functionally equivalent to CCK-8 with enhanced metabolic stability.…”

Section: Mechanisms Targeting the Gastrointestinal Tractmentioning

confidence: 99%

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Pharmacological Treatment of Obesity: Therapeutic Strategies

1999

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Section: Mechanisms Targeting the Gastrointestinal Tractmentioning

confidence: 90%

Section: Mechanisms Targeting the Gastrointestinal Tractmentioning

confidence: 99%

Pharmacological Treatment of Obesity: Therapeutic Strategies

1999

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“…It has been reasoned that the development of biologically stable CCK 1 receptor agonists, which can be administered orally, may provide a means of inhibiting food intake and reducing body weight. There are two main classes, the tetra‐ and hexapeptides and the 1,5‐benzodiazepine CCK 1 receptor agonists, which, like CCK, have been shown to inhibit energy intake in rat models when administered acutely (87–91). In the only report relating to the effects of a CCK 1 receptor agonist, GW181771, in humans, there was a dose‐dependent decrease in energy intake over 24 h in obese women (http://www.gsk.com/press_archive).…”

Section: Therapeutic Potential For Cholecystokinin or Activation Of mentioning

confidence: 99%

Role of cholecystokinin in appetite control and body weight regulation

2005

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Summary Cholecystokinin (CCK), a peptide that is distributed widely throughout the gastrointestinal tract and the central nervous system, has a number of physiological effects including the stimulation of gallbladder contraction and pancreatic and gastric acid secretion, slowing of gastric emptying and suppression of energy intake. This review focuses on current knowledge relating to (i) the effects of CCK on energy intake; (ii) the role for CCK in the pathophysiology of obesity; and (iii) the therapeutic potential for strategies which modulate the action or secretion of CCK in the management of obesity. While CCK plays a role in the acute regulation of appetite and energy intake, there is little evidence to suggest that specific CCK receptor agonists, or modulation of the actions of endogenous CCK by dietary manipulation, have sustainable inhibitory effects on energy intake. Hence, it appears unlikely that manipulating the pathways by which CCK modulates energy intake will prove to be an effective strategy in the long term management of obesity.

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Food and water intake suppression by intracerebroventricular administration of substance P in food- and water-deprived rats

Dib

1999

Brain Research

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Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S

Cited by 8 publications

References 6 publications

Pharmacological Treatment of Obesity: Therapeutic Strategies

Pharmacological Treatment of Obesity: Therapeutic Strategies

Role of cholecystokinin in appetite control and body weight regulation

Food and water intake suppression by intracerebroventricular administration of substance P in food- and water-deprived rats

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