Comparison of the Risk Factor Profile, Stroke Subtypes, and Outcomes Between Stroke Patients Aged 65 Years or Younger and Elderly Stroke Patients: A Hospital-based Study

Chen, Yi-Min; Lin, Ya-Ju; Po, Helen L.

doi:10.1016/j.ijge.2012.11.011

Cited by 13 publications

(15 citation statements)

References 31 publications

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“…In our study, the older patients had higher rates of hypertension, coronary heart disease, atrial fibrillation, and more history of stroke. These results fall in line with results of previous study conducted in very old Asians (Chen et al, ; Lee, Huang, & Weng, ; Wang et al, ). Cardio‐embolism is the most common stroke etiology in LHI patients regardless of age, followed with large‐artery atherosclerosis in the older age group.…”

Section: Discussionsupporting

confidence: 93%

“…It is similar to the data from a randomized trail conducted in Chinese population that included 49 mMCAI patients for DHC and 29 of which (61.7%) were older than 60 years (Zhao et al, 2012). Differences in the proportion of the older between our study and others might be explained by that the elderly were more likely to have cardio-embolism and total anterior circulation infarct in Asian hospital-based stroke patients (Chen, Lin, & Po, 2013 In the present study, we found that LHI of older age was less likely to come from the rural area in our study, this would likely in the older age group, for most of cases of rheumatic heart disease occur in younger populations living in poverty (White et al, 2010). In our study, the older patients had higher rates of hypertension, coronary heart disease, atrial fibrillation, and more history of stroke.…”

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 53%

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Age‐specific clinical characteristics and outcome in patients over 60 years old with large hemispheric infarction

Li¹,

Zhang²,

Tao

et al. 2018

Brain and Behavior

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ObjectiveWe aimed to investigate age‐specific clinical characteristics in patients aged >60 years with large hemispheric infarction (LHI).MethodsWe prospectively enrolled consecutive patients with LHI. Patients were divided into two groups: ≤60 vs. >60 years, and demographics, vascular risk factors, clinical feature, in‐hospital treatment, 3‐month mortality, and unfavorable outcome (defined as a mRS score of 4–6) rate were compared.ResultsOf the 256 cases included, 140 (54.7%) were older than 60 years. Compared with the younger, the older patients had higher rates of hypertension (66.4% vs. 31.0%), coronary heart disease (19.3% vs. 2.6%), atrial fibrillation (53.6% vs. 31.0%; all p < 0.001), more history of stroke (21.4% vs. 5.2%, p < 0.001), less history of rheumatic heart disease (16.4% vs. 30.1%, p = 0.009), and alcohol consumption (12.1% vs. 21.6%, p = 0.043). Cardio‐embolism is the most common stroke etiology regardless of age (55.7% and 38.8%, respectively). Furthermore, the elderly less frequently received decompressive hemicraniectomy (4.3% vs. 15.5%, p = 0.005) and mechanical ventilation (7.9% vs. 16.4%, p = 0.035) and had a higher frequency of stroke‐related complication (83.6% vs. 66.4%, p = 0.001). A total of 26 (18.6%) older patients and 15 (12.9%) younger patients died during hospitalization (p = 0.221), and 59 (42.1%) older patients and 35 (30.2%) younger patients died at 3 months (p = 0.061). Patient aged >60 years had significantly higher unfavorable outcome rate at 3 months (adjusted odds ratio, OR 4.30, 95% confidence interval [CI] 2.08–8.88; p < 0.05]. However, older age is not independently associated with 3‐month mortality (42.1% vs. 30.2%, p = 0.095 [log‐rank test]).ConclusionsLarge hemispheric infarction patients over 60 years old were a little more than those aged ≤60 years and constitute more than half of those suffered from malignant brain edema and two thirds of in‐hospital death and 3‐month mortality. The elderly had more cardio‐origin risk factors, received less aggressive hospital treatment, and showed higher risk of unfavorable outcome than the younger.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Age‐specific clinical characteristics and outcome in patients over 60 years old with large hemispheric infarction

Li¹,

Zhang²,

Tao

et al. 2018

Brain and Behavior

View full text Add to dashboard Cite

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“…Compared to elderly patients, these patients were less likely to have atrial fibrillation, a prior history of stroke, systemic infection, upper gastrointestinal bleeding, a low National Institutes of Health Stroke Scale score on admission, or a prolonged hospital stay. Younger patients also had a higher frequency of stroke of unclear etiology or lacunar type compared to older patients, who were conversely likely to have cardiogenic embolism or large-vessel infarctions 15 .…”

Section: Discussionmentioning

confidence: 95%

“…A study in Taiwan showed a higher prevalence of stroke in younger patients who were male and had a history of smoking, hypercholesterolemia, hypertriglyceridemia, and a high body mass index 15 . Compared to elderly patients, these patients were less likely to have atrial fibrillation, a prior history of stroke, systemic infection, upper gastrointestinal bleeding, a low National Institutes of Health Stroke Scale score on admission, or a prolonged hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Recurrent Strokes in Young and Elderly Patients: A Hospital-based Study

Yuan

et al. 2015

International Journal of Gerontology

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Keywords: myocardial infarction, recurrent stroke, risk factors of stroke s u m m a r y Background: Recurrent stroke is often devastating, and can cause severe disability or death. Risk factors associated with recurrent strokes unrelated to atrial fibrillation have been well identified; however, it remains to be further elucidated whether the risk factors for recurrent stroke are the same in young as in older patients. Methods: Data from 1017 stroke patients unrelated to atrial fibrillation were retrospectively reviewed. Risk factors analyzed included sex, smoking history, previous history of ischemic stroke or transient ischemic attack, hypertension, diabetes mellitus, coronary atherosclerotic heart disease, and previous myocardial infarction. All patients were followed up via telephone 1 year after their initial strokes. Logistic regression was used to assess the associations between the various factors and risk of recurrent stroke events. Results: Predictive independent risk factors of recurrent stroke in older men included previous history of myocardial infarction [odds ratio (OR), 6.761; 95% confidence interval (CI), 1.030e44.371], ischemic stroke or transient ischemic attack (OR, 2.496; 95% CI, 1.567e3.976), diabetes mellitus (OR, 1.986; 95% CI, 1.223e3.227), and coronary atherosclerotic disease (OR, 1.733; 95% CI, 1.010e2.974). In young men, hypertension (OR, 1.709; 95% CI, 1.104e2.645), coronary atherosclerotic heart disease (OR, 1.812; 95% CI, 1.129e2.911), and previous history of ischemic stroke or transient ischemic attack (OR, 2.317; 95% CI, 1.580e3.397) were independent risk factors of recurrent strokes. Conclusion: The predictive independent risk factors of recurrent stroke differ between young and older stroke patients. Our findings may help guide the prevention of recurrent strokes.

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Lesser Severity at Onset but Poorer Prognosis in Elderly Stroke Patients

Liou

2014

International Journal of Gerontology

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Comparison of the Risk Factor Profile, Stroke Subtypes, and Outcomes Between Stroke Patients Aged 65 Years or Younger and Elderly Stroke Patients: A Hospital-based Study

Cited by 13 publications

References 31 publications

Age‐specific clinical characteristics and outcome in patients over 60 years old with large hemispheric infarction

Age‐specific clinical characteristics and outcome in patients over 60 years old with large hemispheric infarction

Risk Factors Associated with Recurrent Strokes in Young and Elderly Patients: A Hospital-based Study

Lesser Severity at Onset but Poorer Prognosis in Elderly Stroke Patients

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