Comparison of the retinal vascular network and structure in patients with optic neuritis associated with myelin oligodendrocyte glycoprotein or aquaporin-4 antibodies: an optical coherence tomography angiography study

Retinal structural and microvascular changes in myelin oligodendrocyte glycoprotein antibody disease and neuromyelitis optica spectrum disorder: An OCT/OCTA study

“…Concerning microvascular changes after ON, our current study did not find any significant difference between NMOSD-ON and MOG-ON patients which is in line with a previous report ( 23 ). It is suggested that ON in MOGAD is acute and severe which is similar to ON in NMOSD; however, the long-term prognosis is better in MOGAD compared with NMOSD.…”

“…Our current report showed retinal thinning and reduced microvascular densities in NMOSD and MOGAD patients compared with controls which are congruent with previous OCT/OCTA reports ( 20 – 23 ) indicating that neurodegeneration and microvascular impairment occur during the disease cascade. Our study showed thinner GCIPL thickness and reduced SVP density in MOGAD patients compared with NMOSD patients.…”

“…The novel findings in our study were significantly thinner GCIPL thickness and reduced SVP density in MOGAD compared with NMOSD. The SVP, located in the GCIPL, is responsible for the metabolic supply of neurons in these layers ( 24 ), where reduced thicknesses have been reported in both MOGAD and NMOSD ( 11 , 22 , 23 ). With regard to retinal neurodegeneration, it is suggested that retinal thinning in NMOSD is as severe as in MOGAD ( 25 ); similarly, a recent report showed that microvascular impairment in MOGAD and NMOSD was similar ( 23 ).…”

“…The SVP, located in the GCIPL, is responsible for the metabolic supply of neurons in these layers ( 24 ), where reduced thicknesses have been reported in both MOGAD and NMOSD ( 11 , 22 , 23 ). With regard to retinal neurodegeneration, it is suggested that retinal thinning in NMOSD is as severe as in MOGAD ( 25 ); similarly, a recent report showed that microvascular impairment in MOGAD and NMOSD was similar ( 23 ). However, a recent study showed that retinal thinning was more severe in MOGAD than in NMOSD which is congruent with our structural report ( 26 ).…”

A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders: A systematic review and meta-analysis

“…A total of 42 studies were included in our systematic review for qualitative synthesis with the year of publication from 2009 to September 1st, 2021. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 All studies included in our review were considered to be of high quality, and the details of quality assessment are provided in Table S1 and Table S2 . The reported mean or median duration of the disease was more than 6 months.…”