Comparison of the respiratory depressant effects of halothane and enflurane in humans.

Izumi, Yukio; Kochi, Tetsuo; Mizuguti, Tadanobu

doi:10.2199/jjsca.10.186

Cited by 1 publication

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“…7 have reported values of TI and TE amounting to 1.35 and 1.61s in 1.1 MAC of enflurane anesthesia, respectively. Corresponding values in 1 MAC of halothane anesthesia reported by Izumi et al 3 amounted to 0.90 and 1.52s and those reported by Byrick et a1. 4 with 1.4 MAC of halothane amounted to 0.90 and LOs, respectively.…”

Section: Discussionsupporting

confidence: 69%

“…Taking these points together we believe, at least in the present experimental condition, VT/Tr accurately reflects central neural drive. Thus current results and those of Izumi et al 3 and Drummond et al" indicate that the depressant effect of sevoflurane on the central respiratory drive is slightly greater than that of halothane and is less than that of enflurane at 1 MAC.…”

Section: Discussionsupporting

confidence: 69%

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Breathing pattern and respiratory mechanics in sevoflurane-anesthetized humans

et al. 1990

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In order to determine the respiratory effects of sevoflurane in humans, breathing pattern and mechanical behavior of respiratory system were investigated in ten subjects at anesthetic depth of 1 MAC (minimum alveolar concentration). Average tidal volume and breathing frequency amounted to 275 ml and 20.9 breaths per minute. Arterial carbon dioxide tension amounted to 45.6 mmHg. Duration of inspiration was 1.06s and that of expiration was 1.92s. Mean inspiratory flow rate amounted to 259 ml.s(-1). Average value of passive respiratory elastance determined by the method of Zin et al. amounted to 21.8 cmH(2)O. l(-1), while those of active respiratory elastance and resistance obtained by the method of Behrakis et al. were 28.0 cmH(2)O. l(-1) and 3.15 cmH(2)O. l(-1).s(-1), respectively. Values of these variables were compared to those reported in halothane and enflurane anesthesia and possible explanations of the differences between the anesthetics are discussed.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 69%