Comparison of the Relationships between Serum Apolipoprotein B and Serum Lipid Distributions

Abstract

Background: Apolipoprotein B (apo B) has been reported to be a better predictor of coronary artery disease than cholesterol indices. The objectives of this study were to evaluate concordances/discordances between cholesterol indices and apo B and to assess the factors that influence them. Methods: For this study, 11 816 individuals (6965 males, 4851 females), none of whom had a past history of coronary artery disease, were selected from among visitors to the health promotion center at Kangbuk Samsung Hospital between January and December 2002. We assessed concordances between the biochemical indices of atherogenicity and evaluated factors associated with discordances. Results: Apo B and various cholesterol indices were correlated, although concordance fell within the range 47%-56%. Multinomial logistic regression analysis showed an increasing risk of a disproportionately higher apo B than LDL-cholesterol in males, the elderly, smokers, individuals with metabolic syndrome, in those with high HDL-cholesterol or triglyceride (TG) concentrations or larger waist circumferences, and in those with low total cholesterol (TC). Conclusions: The introduction of apo B to standard lipid profile testing could improve the evaluation of risk factors of coronary artery disease and aid more accurate assessment of the effects of cholesterol-lowering therapy, particularly in males, the elderly, smokers, or in individuals with metabolic syndrome, high HDL-cholesterol, high TGs, larger waist circumferences, or low TC.

Oxidative Modification of Low-Density Lipoprotein in Relation to Dyslipidemia and Oxidant Status in Children With Steroid Sensitive Nephrotic Syndrome

“…However, the apo-A-I findings disagree with those of Abdel Ghany et al, (32) and Zhang et al, (44), as they reported decreased levels of apo-A. However, the increased apo-A-I and apo-B in NS could be explained by the hypothesis that changes in plasma oncotic pressure following hypoalbuminemia and may be involved in stimulating the transcription of a group of liver secreted proteins (38,45).…”

The apoB/apoA-I Ratio is a Strong Predictor of Cardiovascular Risk

“…In our previous review (3) we summarized these results from Stewart et al (125), Korean studies (126)(127)(128) and studies from India (129) and Canada (130). In these papers the highest values for the apo-ratio were found in those who had most manifestations of the MetS.…”

“…In fact, the apo-ratio has also been found to be a valuable summarizing index of lipid-abnormalities and their complications in a large number of studies of the MetS and/or diabetes (125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139)143,144). In addition, the apo-ratio values are also increased in patients with hypertension, obesity, in pubertal children and in those with heredity for CV diseases (130,141).…”

Effects of human follicular fluid and high-density lipoproteins on early spermatozoa hyperactivation and cholesterol efflux

“…Phospholipids were measured according to their phosphorus content ( 29 ) following lipid extraction. ApoA-I was measured by a rate nephelometry method using the IMMAGE® immunochemistry system (Beckman Coulter, Villepinte, France), which is widely spread ( 30 ).…”

“…We fi rst evaluated the effects of varying FF concentrations (5,10,20,30,40, and 50%, v/v in modifi ed B2 medium) on spermatozoa hyperactivation process after 5 min of incubation at 37°C ( Fig. 1A ).…”