Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography

Zorlu, Çağrı; Köseoğlu, Cemal

doi:10.1177/0003319719892160

Cited by 24 publications

(30 citation statements)

References 32 publications

(51 reference statements)

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“…Inflammatory factors cause atherosclerotic plaques to develop and become unstable, leading to thrombosis and resulting in obstruction of the coronary arteries (29). Studies have indicated that ACS is an inflammation-mediated atherosclerotic disease and that inflammation and immune responses have an important role at all stages of atherosclerosis (30).…”

Section: Discussionmentioning

confidence: 99%

Association between α1‑antitrypsin and acute coronary syndrome

Liu

Huang

et al. 2020

Exp Ther Med

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α1-antitrypsin (AAT) is a protein released as part of the anti-inflammatory response. It regulates the activity of serine proteinases and has a crucial role in the pathogenesis of acute coronary syndrome (ACS). The present study aimed to examine its role in patients with ACS. The plasma samples of 117 patients were collected at the Cardiology Department of the Affiliated Hospital of Youjiang Medical University (Baise, China). These included 46 cases of ACS (who met the diagnostic criteria for ACS and had ≥50% luminal stenosis of any coronary vessel), 35 cases of stable angina (SA; with ≥50% luminal stenosis of any coronary vessel but in a stable condition) and 36 normal healthy controls (subjects with no luminal stenosis in their coronary arteries). Plasma AAT protein concentrations were measured by ELISA and clinical data were collected. The plasma levels of AAT protein in patients with ACS were lower than those in controls and cases of SA (P<0.05), and the levels tended to decrease with the number of coronary artery lesions involved. There were no significant associations of the expression of plasma AAT protein and the number of diseased vessels in patients or the degree of stenosis. There was no correlation between the plasma protein levels of AAT and Gensini scores of patients with ACS. In conclusion, the plasma AAT protein levels in patients with ACS may contribute to the occurrence and development of coronary artery disease.

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Section: Discussionmentioning

confidence: 99%

Association between α1‑antitrypsin and acute coronary syndrome

Liu

Huang

et al. 2020

Exp Ther Med

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“…Notably, the presence of inflammatory elements has also been set as a feature for the population at high risk of CIN. Several studies have reported that the presence of active inflammatory processes biomarkers in patients with CVD may attribute its high-risk to developing CIN after CM exposure [30,31,[91][92][93][94] .…”

Section: Cin Pathophysiology In the Context Of Cvdmentioning

confidence: 99%

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Cervantes-Gracia

Raja²,

Llanas-Cornejo

et al. 2020

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Utilization of contrast media to visualize vasculature structures in the setting of cardiovascular disorders (CVD) can lead to acute kidney injury, referred to as contrast-induced nephropathy (CIN). CIN can potentiate mortality and hospitalization in aged individuals, patients with CVD, nephropathy, enhancing kidney damage, and cardiac events. Preventing CIN by identifying risk factors is important. The underlying mechanisms of CIN pathology are unclear, but the key factors include direct cytotoxicity, oxidative stress, vascular and endothelial dysfunction and inflammatory processes. Reactive Oxygen Species and inflammatory mediators have been proposed as key factors influencing the development of CIN and CVD, and the elucidation of the interplay between the mechanisms evoked by them may provide a better understanding of the signaling processes happening in these conditions, thereby potentially enabling early identification, prevention and characterization of novel drug targets.

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“…7 Zorlu and Koseoglu. 3 did not report the LMR. However, this may be investigated in future studies.…”

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confidence: 99%

Mean Platelet Volume to Lymphocyte Ratio: A New Biomarker to Predict Contrast-Induced Nephropathy After Coronary Angiography

et al. 2020

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Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute renal failure and related with prolonged hospitalization, increased morbidity, mortality, and economic costs. 1 Given that inflammation plays a significant role in the pathophysiology of CIN and acute coronary syndrome (ACS), inflammation-related biomarkers have been investigated for the prediction of CIN. 2 Among these biomarkers, hematological parameters have been the focus of research due to fact that they are cheap, simple to calculate, and easily accessible. Zorlu and Koseoglu 3 compared several admission hematological inflammatory markers for the prediction of CIN in ACS patients who underwent percutaneous coronary intervention (PCI). Among several inflammatory parameters including mean platelet volume (MPV), lymphocyte count, platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio, and mean platelet volume to lymphocyte ratio (MPVLR), only the MPVLR remained as an independent predictor of CIN. Although this study has several limitations (eg, retrospective and observational design as well as the number of patients) as described by the authors, it has several "take home messages." In this context, we would like to comments on the study design and statistical analysis. The authors 3 performed multiple linear regression analysis to investigate predictors of CIN. In addition to various hematological and inflammatory markers, they also included clinical variables into regression model such as age, left ventricular ejection fraction (LVEF), and diabetes mellitus, which are associated with CIN development. 4,5 Multivariate analysis demonstrated that age and LVEF are also independent predictors of CIN in addition to hematological parameters including hemoglobin and lymphocyte counts and MPVLR. Moreover, there were significant differences between the 2 study groups in terms of these clinical variables. Making a firm conclusion about the superiority and predictive power of these inflammatory markers for CIN may not be possible in the light of these results. From a biomarker perspective, it would be preferable if the authors had performed a propensity score matching analysis

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Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography

Cited by 24 publications

References 32 publications

Association between α1‑antitrypsin and acute coronary syndrome

Association between α1‑antitrypsin and acute coronary syndrome

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Mean Platelet Volume to Lymphocyte Ratio: A New Biomarker to Predict Contrast-Induced Nephropathy After Coronary Angiography

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Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome After Coronary Angiography

Cited by 24 publications

References 32 publications

Association between &alpha;1‑antitrypsin and acute coronary syndrome

Association between &alpha;1‑antitrypsin and acute coronary syndrome

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Mean Platelet Volume to Lymphocyte Ratio: A New Biomarker to Predict Contrast-Induced Nephropathy After Coronary Angiography

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Association between α1‑antitrypsin and acute coronary syndrome

Association between α1‑antitrypsin and acute coronary syndrome