Comparison of the Protective Effect of Various Flavonoids Against Lipid Peroxidation of Erythrocyte Membranes (Induced by Cumene Hydroperoxide)

Affany, A.; Salvayre, Robert; Douste‐Blazy, Louis

doi:10.1111/j.1472-8206.1987.tb00578.x

Cited by 46 publications

(11 citation statements)

References 24 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, vitamin E deficiency has been observed to produce symptoms similar to mild lathrysm (86). There is also an expansive literature, often ignored from a nutritional perspective, that focuses on the cathetins and bioflavonoids as beneficial to extracellular matrix maturation (87)(88)(89)(90)(91)(92)(93)(94)(95). The effects of PQQ could fit into this latter category.…”

Section: Discussionmentioning

confidence: 98%

Physiologic Importance of Pyrroloquinoline Quinone

Smidt

Steinberg

Rucker

1991

Experimental Biology and Medicine

View full text Add to dashboard Cite

Pyrroloquinoline quinone (PQQ, methoxatin) is a dissociable cofactor for a number of bacterial dehydrogenases. The compound is unusual because of its ability to catalyze redox cycling reactions at a high rate of efficiency and it has the potential of catalyzing various carbonyl amine reactions as well. In methylotrophic bacteria, PQQ is derived from the condensation of L-tyrosine with L-glutamic acid. Whether or not PQQ serves as a cofactor in higher plants and animals remains controversial. Nevertheless, a strong case may be made that PQQ and related quinoids have nutritional and pharmacologic importance. In highly purified, chemically defined diets, PQQ stimulates animal growth. Furthermore, PQQ deprivation appears to impair connective tissue maturation, particularly when initiated in utero and throughout perinatal development.

show abstract

Section: Discussionmentioning

confidence: 98%

Physiologic Importance of Pyrroloquinoline Quinone

Smidt

Steinberg

Rucker

1991

Experimental Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…Flavonoids, natural polyphenols of plant origin, are known to be effective inhibitors of lipid peroxidation, which is commonly associated with their radical-scavenging ability. [231][232][233][234][235][236] Besides, they reveal pronounced pharmacological and vitamin-like activities explained, at least partly, by their chain-breaking ability. [237][238][239] It has been found that the "classic" model of the antioxidative effect on the oxychemiluminescence process, whose principles are set out in Section 4.2, is not quite suitable for the case of flavonoids.…”

Section: Peculiarities Of Analyzing the Natural Antioxidantsmentioning

confidence: 99%

Peroxy-radical-mediated chemiluminescence: mechanistic diversity and fundamentals for antioxidant assay

Fedorova¹,

Trofimov²,

Vasil’ev³

et al. 2006

Arkivoc

View full text Add to dashboard Cite

Herein, we give a retrospective overview and analyze recent developments in the field of chemiluminescence derived from organic oxidation processes (so called oxychemiluminescence), most prominently, mediated by peroxy radicals. As evidenced from the presented analysis, the diversities of the reaction and the excited-state-generation mechanisms are governed mainly by a diverse chemical nature of substrates being oxidized. The notable oxychemiluminescence cases, which involve peroxy radicals as key reactive species, refer to oxidation of saturated and unsaturated hydrocarbons, polymers, lipids and proteins. The general feature of the considered chemiluminescence processes pertains to a formation of high-energy cyclic intermediates (tetroxides and/or dioxetanes), whose cleavage yields electronically excited products. The considered modes of the chemiluminescence enhancement encompass the energytransfer and the electron-transfer mechanisms. Most prominent application of the discussed oxychemiluminescence phenomenon resides in a versatile chemiluminescent assay to monitor antioxidants (both their concentration and reactivity) in chemical and biological media.

show abstract

“…EGCG has protected erythrocyte membrane Ca 2+ -ATPase and (Na + , K + )-ATPase against inactivation induced by tert-butyl hydroperoxide [22], protected erythrocytes against oxidative effects of cigarette smoke [23], and partly prevented hemolysis induced by cyclosporine [24]. (+)-Catechin has protected erythrocyte membranes against lipid peroxidation induced by hydrogen peroxide [25] and erythrocytes against hemolysis induced by cumene hydroperoxide [26]. Catechins, including EGCG and (+)-catechin, among other flavonoids, have been reported to increase the activity of a plasma membrane redox system (PMRS) that transfers electrons from intracellular substrates to extracellular electron acceptors by entering erythrocytes and donating electrons to PMRS [27].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Catechins with Human Erythrocytes

et al. 2020

View full text Add to dashboard Cite

The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin, (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes and their protective effects against oxidative damage of erythrocytes. Uptake of the catechins by erythrocytes was studied by fluorimetry, their interaction with erythrocyte membrane was probed by changes in erythrocyte osmotic fragility and in membrane fluidity evaluated with spin labels, while protection against oxidative damage was assessed by protection against hemolysis induced by permanganate and protection of erythrocyte membranes against lipid peroxidation and protein thiol group oxidation. Catechin uptake was similar for all the compounds studied. Accumulation of catechins in the erythrocyte membrane was demonstrated by the catechin-induced increase in osmotic resistance and rigidification of the erythrocyte membrane detected by spin labels 5-doxyl stearic acid and 16-doxyl stearic acid. (−)-Epigallocatechin and EGCG inhibited erythrocyte acetylcholinesterase (mixed-type inhibition). Catechins protected erythrocytes against permanganate-induced hemolysis, oxidation of erythrocyte protein thiol groups, as well as membrane lipid peroxidation. These results contribute to the knowledge of the beneficial effects of catechins present in plant-derived food and beverages.

show abstract

Comparison of the Protective Effect of Various Flavonoids Against Lipid Peroxidation of Erythrocyte Membranes (Induced by Cumene Hydroperoxide)

Cited by 46 publications

References 24 publications

Physiologic Importance of Pyrroloquinoline Quinone

Physiologic Importance of Pyrroloquinoline Quinone

Peroxy-radical-mediated chemiluminescence: mechanistic diversity and fundamentals for antioxidant assay

Interaction of Catechins with Human Erythrocytes

Contact Info

Product

Resources

About