Comparison of the Properties of Brand-Name and Generic Nadifloxacin Creams

Inoue, Yutaka; Matsumoto, Miruto; Kimura, Masayuki; Tanaka, Toru; Kanamoto, Ikuo

doi:10.3390/medicina47110089

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…The feeling associated with the use of a semisolid preparation can be evaluated by assessing extensibility and hardness, which are indexes of spreadability and yield value, using a spread meter [ 10 ]. Therefore, the spreadability and yield value of each ointment preparation were calculated using a spread meter, and the physical properties were evaluated ( Table 3 and Figures 1 and 2 ).…”

Section: Resultsmentioning

confidence: 99%

Evaluation between the Usability and Physicochemical Property of Acyclovir Ointments

Inoue

Mitsumori

Shinohara

et al. 2018

Journal of Pharmaceutics

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A lot of prescription medicines have become switch over-the-counter (OTC) medicines. However, additives in brand-name drugs, generic drugs, and switch OTC drugs differ; therefore, the feelings associated with the use of these medicines vary for patients. The aim of this study was to compare the physicochemical properties and the feeling of use (assuming skin as an index of usability) of acyclovir (ACV) ointments. Five ACV ointments were used: ACV-A, a brand-name drug, ACV-B and ACV-C, generic drugs, and ACV-D and ACV-E, switch OTC drugs. The physicochemical properties were evaluated by determining the content uniformity, water content, flattening, viscosity and viscoelasticity, and near-infrared (NIR) absorption spectroscopy. Skin friction was measured to evaluate the feeling associated with use. Results of the content uniformity test indicated that the ACV content was uniform, and equivalence was observed. Measurement of moisture content indicated that this parameter differed in each ointment preparation. The yield value, which was calculated by measuring flattening, was 4416.7 dyne/cm2 for ACV-A, 1175.7 dyne/cm2 for ACV-B, 2114.9 dyne/cm2 for ACV-C, 4234.5 dyne/cm2 for ACV-D, and 3620.7 dyne/cm2 for ACV-E. Measurement of viscosity and viscoelasticity revealed that viscosity increased with time and the viscoelasticity of each ointment. The second derivative of the NIR spectrum revealed that ACV-B and ACV-C had a wider spectrum of absorption than the other ointments. ACV-B had lesser friction than other ointments. These findings suggest that differences in the type and content of additives (macrogol) result in differences in the physicochemical properties of individual ointments.

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Section: Resultsmentioning

confidence: 99%

Evaluation between the Usability and Physicochemical Property of Acyclovir Ointments

Inoue

Mitsumori

Shinohara

et al. 2018

Journal of Pharmaceutics

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“…Researchers at the Laboratory of Drug Safety Management previously reported a correlation between the physicochemical properties and feel of antimicrobial and antiviral creams [ 12 ]. TA ointments are drugs with a “medium” ranking as a steroid.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments

Inoue

Maeda

Furuya

et al. 2013

Results in Pharma Sciences

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The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and measurement of viscoelasticity. The human sensory test examined 5 aspects (texture, cohesiveness, spreadability, smell, and feel). Three TA ointments were used: TA-A, a brand-name preparation, and TA-B and TA-C, two generics. The sensory test revealed significant differences between TA-A and TA-B and TA-C in terms of cohesiveness and spreadability. Significant differences between TA-A and TA-C and between TA-B and TA-C in terms of feel were noted. Microscopic examination revealed that TA-C had good dispersibility while TA-A and TA-B produced crystallization. NIR spectroscopy revealed differences in absorption spectra attributed to oil and water content in TAA, TA-B, and TA-C. Measurement of water content indicated water content of 0.06 ± 0.02% for TA-A, 0.08 ± 0.08% for TA-B, and 36.7 ± 1.19% for TA-C. Assessment of viscoelasticity indicated that stress decreased for all 3 ointments at 35 °C compared to that at 25 °C. TA-A and TA-B were found to have a higher percent decrease in stress than was TA-C. These findings indicate that differences in the types and content of additives caused differences in the physicochemical properties of individual ointments. In addition, differences in physicochemical properties presumably resulted in the close correlation between cohesiveness and spreadability in the sensory test.

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A Nanocarrier Skin-Targeted Drug Delivery System using an Ascorbic Acid Derivative

et al. 2017

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Comparison of the Properties of Brand-Name and Generic Nadifloxacin Creams

Cited by 3 publications

References 12 publications

Evaluation between the Usability and Physicochemical Property of Acyclovir Ointments

Evaluation between the Usability and Physicochemical Property of Acyclovir Ointments

Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments

A Nanocarrier Skin-Targeted Drug Delivery System using an Ascorbic Acid Derivative

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