Comparison of the prevalence and nature of potentially inappropriate medication use in geriatric outpatients between tertiary and community healthcare settings: a multicenter cross-sectional study

Zeng, Yan; Yu, Yajuan; Liu, Qingyang; Su, Su; Yang, Lin; Gu, Hong-Yan; Chen, Shicai; Li, Pengmei; Xu, Tongwen; Sun, Naizhao; Lin, Tao; Huang, Qian; Yu, Fan; Wang, Fengzhi; Yan, Suying

doi:10.1007/s11096-022-01380-0

Cited by 4 publications

(11 citation statements)

References 45 publications

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“…Clinicians should carefully review drug therapies and detect PIMs in patients with hyperpolypharmacy. Unlike other studies [ 30 , 48 ], the risk of MRP was higher in male patients in our study.…”

Section: Discussioncontrasting

confidence: 95%

“…PIMs in this study population differed from our previous study among outpatients [ 30 ]. In this study, the most common PIM item according to the Beers criteria was vasodilators.…”

Section: Discussioncontrasting

confidence: 73%

“…Since there are overlaps and differences between different PIM judgment criteria [29], the combination of Beers criteria and STOPP criteria can detect more PIMs. PIMs in this study population differed from our previous study among outpatients [30]. In this study, the most common PIM item according to the Beers criteria was vasodilators.…”

Section: Discussioncontrasting

confidence: 72%

“…Hypertension, diabetes, coronary heart disease, cerebral infarction, and hyperlipidemia are common chronic diseases in older adults [ 30 ]. Comorbidities such as endocrine and metabolic disorders, diabetes, coronary heart disease, and cerebrovascular disease were factors of polypharmacy in older adults [ 44 – 46 ].…”

Section: Discussionmentioning

confidence: 99%

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A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

et al. 2023

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Background Research on potentially inappropriate medications (PIM) and medication-related problems (MRP) among the Chinese population with chronic diseases and polypharmacy is insufficient. Objectives This study aimed to investigate the prevalence of PIM and MRP among older Chinese hospitalized patients with chronic diseases and polypharmacy and analyze the associated factors. Methods A retrospective cross-sectional study was conducted in five tertiary hospitals in Beijing. Patients aged ≥ 65 years with at least one chronic disease and taking at least five or more medications were included. Data were extracted from the hospitals’ electronic medical record systems. PIM was evaluated according to the 2015 Beers criteria and the 2014 Screening Tool of Older Persons’ Prescriptions (STOPP) criteria. MRPs were assessed and classified according to the Helper-Strand classification system. The prevalence of PIM and MRP and related factors were analyzed. Results A total of 852 cases were included. The prevalence of PIM was 85.3% and 59.7% based on the Beers criteria and the STOPP criteria. A total of 456 MRPs occurred in 247 patients. The most prevalent MRP categories were dosages that were too low and unnecessary medication therapies. Hyperpolypharmacy (taking ≥ 10 drugs) (odds ratio OR 3.736, 95% confidence interval CI 1.541–9.058, P = 0.004) and suffering from coronary heart disease (OR 2.620, 95%CI 1.090–6.297, P = 0.031) were the influencing factors of inappropriate prescribing (the presence of either PIM or MRP in a patient). Conclusion PIM and MRP were prevalent in older patients with chronic disease and polypharmacy in Chinese hospitals. More interventions are urgently needed to reduce PIM use and improve the quality of drug therapies.

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Section: Discussioncontrasting

confidence: 95%

“…PIMs in this study population differed from our previous study among outpatients [ 30 ]. In this study, the most common PIM item according to the Beers criteria was vasodilators.…”

Section: Discussioncontrasting

confidence: 73%

Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

et al. 2023

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“…Following exclusion of 213 duplicate studies, 1258 studies were excluded by the titles and abstracts. Ninety-four studies with 371 224 692 older outpatients were included for analysis (Figure 1; eAppendix 2 in Supplement 1).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide

Tian,

Chen,

Zeng

et al. 2023

JAMA Netw Open

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ImportanceThe use of potentially inappropriate medications (PIMs) is widespread yet continues to receive little attention in outpatient services.ObjectiveTo estimate the overall prevalence of PIM use in outpatient services.Data SourcesPubMed, Embase, and Web of Science were searched to identify relevant studies published from January 1, 1990, to November 21, 2022.Study SelectionObservational studies that reported the prevalence of PIM use among older patients in outpatient services were screened.Data Extraction and SynthesisTwo reviewers independently selected eligible articles, extracted data, and assessed the risk of bias. A random-effects meta-analysis was conducted to pool the prevalence estimates.Main Outcomes and MeasuresThe global patterns in the prevalence of PIM use among older patients in outpatient services were estimated, and the temporal trends and regional differences in PIM use were investigated.ResultsA total of 94 articles with 132 prevalence estimates were analyzed, including nearly 371.2 million older participants from 17 countries. Overall, the pooled prevalence of PIM use was 36.7% (95% CI, 33.4%-40.0%). Africa had the highest prevalence of PIM use (47.0%; 95% CI, 34.7%-59.4%), followed by South America (46.9%; 95% CI, 35.1%-58.9%), Asia (37.2%; 95% CI, 32.4%-42.2%), Europe (35.0%; 95% CI, 28.5%-41.8%), North America (29.0%; 95% CI, 22.1%-36.3%), and Oceania (23.6%; 95% CI, 18.8%-28.8%). In addition, the prevalence of PIM use is highest in low-income areas. Use of PIMs among older patients has become increasingly prevalent in the past 2 decades.Conclusions and RelevanceThis study of patterns of PIM use by different groups, such as geographic regions and World Bank countries, suggests noticeable geographic environment and economic income differences in the burden of PIMs in outpatient services. Furthermore, the high prevalence trend in the past 2 decades indicates that the global burden of PIM use continues to be worthy of attention.

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Prevalence and associated factors of potentially inappropriate medication in community-dwelling older adults in china: A meta-analysis

LUO,

KONG,

LYU

et al. 2024

Chinese General Practice Journal

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Comparison of the prevalence and nature of potentially inappropriate medication use in geriatric outpatients between tertiary and community healthcare settings: a multicenter cross-sectional study

Cited by 4 publications

References 45 publications

A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide

Prevalence and associated factors of potentially inappropriate medication in community-dwelling older adults in china: A meta-analysis

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