Background: Landslide-affecting factors are uncorrelated or non-linearly correlated, limiting the predictive performance of traditional machine learning methods for landslide susceptibility assessment. Deep learning methods can take advantage of the high-level representation and reconstruction of information from landslide-affecting factors. In this paper, a novel deep learning-based algorithm that combine classifiers of both deep learning and machine learning is proposed for landslide susceptibility assessment. A stacked autoencoder (StAE) and a sparse autoencoder (SpAE) both consist of an input layer for raw data, hidden layer for feature extraction, and output layer for classification and prediction. As a study case, Oda City and Gotsu City in Shimane Prefecture, southwestern Japan, were used for susceptibility assessment and prediction of landslides triggered by extreme rainfall. Results: The prediction performance was compared by analyzing real landslide and non-landslide data. The prediction performance of random forest (RF) was evaluated as better than that of a support vector machine (SVM) in traditional machine learning, so RF was combined with both StAE and SpAE. The results show that the prediction ratio of the combined classifiers was 93.2% for StAE combined with RF model and 92.5% for SpAE combined with RF model, which were higher than those of the SVM (87.4%), RF (89.7%), StAE (84.2%), and SpAE (88.2%). Conclusions: This study provides an example of combined classifiers giving a better predictive ratio than a single classifier. The asymmetric and unsupervised autoencoder combined with RF can exploit optimal non-linear features from landslide-affecting factors successfully, outperforms some conventional machine learning methods, and is promising for landslide susceptibility assessment.