Comparison of the Predictive Value of Inflammatory Biomarkers for the Risk of Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

Li, Jingyi; Luo, Haowen; Chen, Yongsen; Wu, Bin; Han, Mengqi; Jia, Weijie; Wu, Yifan; Cheng, Rui; Wang, Xiaoman; Ke, Jingyao; Xian, Hongfei; Liu, JianMo; Yu, Pengfei; Tu, Jianglong; Yi, Yingping

doi:10.2147/cia.s425393

Cited by 5 publications

(1 citation statement)

References 47 publications

(47 reference statements)

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“…Firstly, our recent study indicated that hospitalized patients with high SIRI had an increased risk of DVT, which is a relatively common cause of death worldwide ( 40 ). Meanwhile, high SIRI level was also found to be an independent risk factor for pneumonia ( 41 , 42 ), which was proved to be the most significant mediator contributing to the largest proportions of excess mortality following hip fracture ( 43 ). In addition, Lu et al reported that SIRI was positively correlated with the occurrence of postoperative delirium in older patients with hip arthroplasty surgery ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study

Fang,

Gao,

Wang

et al. 2024

Front. Med.

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ObjectiveWith a rapidly aging global population, the assessment of mortality risk following hip fracture in older adults has received increasing attention. Recently, the system inflammation response index (SIRI) has been identified as a novel prognostic marker to reflect both systemic inflammation and immune status. However, it is not yet known whether SIRI is a potential predictor of subsequent death in hip fracture patients. Therefore, this study aimed to investigate the association between SIRI and mortality in older patients with hip fracture.MethodsA total of 1,206 older hip fracture patients undergoing surgery between January 2013 and December 2022 were consecutively derived from our longitudinal database. Patients were divided into three groups according to SIRI tertiles, calculated as neutrophil × monocyte / lymphocyte. Survival status was obtained from medical records or telephone interviews, and the study outcome was all-cause mortality after hip fracture at the longest follow-up. Multivariate Cox proportional hazard model and restricted cubic spline (RCS) regression model were used to evaluate the association between SIRI and mortality. Moreover, a series of sensitivity analyses were conducted to further validate the robustness of the association.ResultsDuring a median follow-up of 43.85 months, 337 patients (27.94%) died. After full adjustment, each unit increase in SIRI was significantly associated with a 2.2% increase in overall mortality (95% confidence interval [CI]: 1.001–1.042, p = 0.029). Similarly, compared with the first tertile of SIRI, the second and third tertile showed a 1.335-fold (95% CI: 1.011–1.762, p = 0.042) and 1.447-fold (95% CI, 1.093–1.917, p = 0.010) higher risk of death. Sensitivity analyses confirmed the stability of the association. Moreover, RCS analysis revealed a positive non-linear relationship between SIRI and mortality (P for nonlinearity = 0.021).ConclusionHigh SIRI level at admission was significantly and positively associated with an increased risk of death, suggesting that SIRI may be an independent predictor of mortality in older patients with hip fracture.

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