Comparison of the Predictive Performances of qSOFA, APACHE II, and SGS for Evaluation of the Disease Prognosis of CCHF Patients at the Emergency Department

Demirtaş, Erdal; Bakır, Mehmet; Büyüktuna, Seyit Ali; Öksüz, Caner; Öz, Murtaza; Cebecioğlu, Kıvanç; Ünlüsavuran, Meltem

doi:10.7883/yoken.jjid.2019.507

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Secondary infection of parenchymal cells occurs by macrophage migration. Macrophage and endothelial cell activation induces inflammatory and vasoactive processes, resulting in systemic inflammatory response syndrome (SIRS) (5). Coagulation system activation and extensive fibrin accumulation in the vascular beds lead to disseminated intravascular coagulation (DIC) and multiple organ failure (MOF) (2).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Procalcitonin, Lactate Level, and Clinical Prognosis in Patients with Crimean-Congo Hemorrhagic Fever

Kerget

Yılmaz

2021

Düzce Tıp Fakültesi Dergisi

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Aim: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic infection characterized by fever and hemorrhage that is endemic to northeastern Turkey. This study aimed to examine the association between procalcitonin and venous blood gas parameters and clinical course and prognosis in patients with CCHF. Material and Methods: A total of 96 CCHF patients who were followed up in the infectious diseases department between March 2020 and September 2020 were included in the study. The patients' routine laboratory tests, serum procalcitonin, and results of venous blood gas analysis were analyzed retrospectively. Results: There were statistically significant differences in serum platelet, aspartate transaminase, alanine transaminase, creatinine kinase, lactate dehydrogenase, potassium, Creactive protein, sedimentation, D-dimer, activated partial thromboplastin time, ferritin, procalcitonin and lactate levels, and platelet/lymphocyte ratio among the patients with mild, moderate and severe disease (p=0.017 for potassium, p=0.004 for D-dimer, and p<0.001 for rest of others). In receiver operating characteristic curve analysis of serum lactate for the differentiation of patients with severe disease and those with mild/moderate disease, the area under curve was 0.802 and a cut-off value of 1.9 mmol/L had 77.8% sensitivity and 76.9% specificity. For serum procalcitonin, the area under curve was 0.892 and a cut-off value of 0.61 ng/mL had 83.3% sensitivity and 89.7% specificity. Conclusion:Serum procalcitonin and lactate level may be useful and easily obtained parameters to guide the evaluation of clinical severity and follow-up in patients with CCHF.

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Section: Introductionmentioning

confidence: 99%

The Association Between Procalcitonin, Lactate Level, and Clinical Prognosis in Patients with Crimean-Congo Hemorrhagic Fever

Kerget

Yılmaz

2021

Düzce Tıp Fakültesi Dergisi

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show abstract

“…Secondary infection of parenchymal cells occurs by macrophage migration. Macrophage and endothelial cell activation induces inflammatory and vasoactive processes, resulting in systemic inflammatory response syndrome (SIRS) 5 . Coagulation system activation and extensive fibrin accumulation in the vascular beds lead to disseminated intravascular coagulation (DIC) and multiple organ failure (MOF) 2 .…”

Section: Introductionmentioning

confidence: 99%

The association between procalcitonin, venous blood gas parameters, and clinical prognosis in patients with Crimean--Congo Hemorrhagic Fever

Kerget¹,

Kerget

Yılmaz

2021

Preprint

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Objective: Crimean–Congo hemorrhagic fever (CCHF) is a zoonotic infection characterized by fever and hemorrhage that is endemic to northeastern Turkey. This study aimed to examine the association between procalcitonin and venous blood gas parameters and clinical course and prognosis in patients with CCHF. Methods: A total of 96 CCHF patients who were followed up in the infectious diseases department between March and September 2020 were included in the study. The patients’ routine laboratory tests, serum procalcitonin, and results of venous blood gas analysis were analyzed retrospectively. Results: There were statistically significantly differences in serum platelet, aspartate transaminase, alanine transaminase, creatinine kinase, lactate dehydrogenase, potassium, C-reactive protein, sedimentation, D-dimer, activated partial thromboplastin time, ferritin, procalcitonin and lactate levels, and platelet/lymphocyte ratio among the patients with mild, moderate and severe disease (p=0.017 for potassium and p=0.001 for rest of others). In receiver operating characteristic (ROC) curve analysis of serum lactate for the differentiation of patients with severe disease and those with mild/moderate disease, the area under the curve was 0.802 and a cut-off value of 1.9 mmol/L had 77.8% sensitivity and 76.9% specificity. For serum procalcitonin, the area under the ROC curve was 0.892 and a cut-off value of 0.61 ng/ml had 83.3% sensitivity and 89.7% specificity. Conclusion: Serum procalcitonin and lactate levels may be useful and easily obtained parameters to guide the evaluation of clinical severity and follow-up in patients with CCHF.

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Which scoring system is effective in predicting mortality in patients with Crimean Congo hemorrhagic fever? A validation study

Bakır

Öksüz

Karakeçili

et al. 2021

Pathogens and Global Health

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Comparison of the Predictive Performances of qSOFA, APACHE II, and SGS for Evaluation of the Disease Prognosis of CCHF Patients at the Emergency Department

Cited by 3 publications

References 21 publications

The Association Between Procalcitonin, Lactate Level, and Clinical Prognosis in Patients with Crimean-Congo Hemorrhagic Fever

The Association Between Procalcitonin, Lactate Level, and Clinical Prognosis in Patients with Crimean-Congo Hemorrhagic Fever

The association between procalcitonin, venous blood gas parameters, and clinical prognosis in patients with Crimean--Congo Hemorrhagic Fever

Which scoring system is effective in predicting mortality in patients with Crimean Congo hemorrhagic fever? A validation study

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