Comparison of the postoperative intraocular pressure with Betagan, Betoptic, Timoptic, Iopidine, Diamox, Pilopine Gel, and Miostat

Fry, Luther L.

doi:10.1016/s0886-3350(13)80378-1

Cited by 67 publications

(35 citation statements)

References 19 publications

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“…Timolol, betaxolol and levobunolol are β-adrenergic blockers which are most widely used as antiglaucomatous agents in the long-term treatment of glaucoma [1]. β-Blockers have been shown to decrease aqueous humor production by as much as 50% by suppressing adenylate cyclase [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural Effects of Topical Beta-Adrenergic Antagonists and an Alpha-Adrenergic Agonist on the Rabbit Cornea

Polat¹,

Özdemir

Soylu

et al. 1999

Ophthalmologica

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In the present study the effects of β-adrenergic antagonist and α-adrenergic agonist drugs on rabbit corneas were evaluated in vivo by using transmission electron microscopy. Twenty-four New Zealand albino rabbits were divided into six groups according to the drug applied. The rabbits to which only balanced salt solution (BSS) or BSS and benzalkonium chloride (BAC) were applied were taken as the control groups. The other four groups consisted of the rabbits to which Timoptic 0.5%, Betagan 0.5%, Betoptic 0.5% and Iopidine 1% were applied, respectively. All of drugs were instilled topically twice daily for 6 weeks. In the BSS group, all layers of the cornea were ultrastructurally normal. In the BSS and BAC group slight epithelial and endothelial changes were found. However, in the other groups, loss of microvilli, increase in glycogen particles, nuclear indentation, widening of the intercellular spaces and cytoplasmic vacuolization in epithelium were observed. No significant abnormality was found in the basal lamina, stroma and Descemet’s membrane. Slight ultrastructural changes were noted in the endothelium such as vacuolization due to dilatation of the endoplasmic reticulum cisternae and focal cytoplasmic lytic areas. The results of this study indicate that various ultrastructural changes occur in groups treated with antiglaucomatous drug and that topical treatment with timolol and apraclonidine for 6 weeks is more toxic to the rabbit cornea than levobunolol and betaxolol.

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Section: Introductionmentioning

confidence: 99%

Ultrastructural Effects of Topical Beta-Adrenergic Antagonists and an Alpha-Adrenergic Agonist on the Rabbit Cornea

Polat¹,

Özdemir

Soylu

et al. 1999

Ophthalmologica

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“…Several studies have shown that apraclonidine is effective in reducing IOP following manual extracapsular cataract extraction [6, 7]. Others, however, indicate that the drug has no effect in reducing postoperative IOP increases [8, 9]. Finally, some investigators [10, 11] affirm that apraclonidine is useful in controlling IOP when it is administered both pre- and postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Comparative Efficacy of Acetazolamide and Apraclonidine in the Control of Intraocular Pressure following Phacoemulsification

Scuderi

Regine²,

Perdicchi³

et al. 2006

Ophthalmologica

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Purpose: The purpose of our study was to compare the effects of systemically administered acetazolamide and topical apraclonidine 0.5% in the control of intraocular pressure (IOP) following phacoemulsification of senile cataracts. Setting: The study was conducted on patients affected by cataract and followed at the Department of Ophthalmology. Methods: Seventy-eight eyes in 78 patients were selected. Twenty-six eyes were randomly assigned to postoperative treatment with topical apraclonidine 0.5%, 26 received oral acetazolamide and the remaining 26 received no hypotensive treatment (control group). Statistical analyses were performed mainly by means of analyis of variance. Results: IOPs measured 24 h after surgery were significantly (p = 0.01) lower in the apraclonidine group compared to the control group. Conclusions: Our double-blind prospective study conducted on patients randomly assigned to treatment with apraclonidine or acetazolamide shows that the former drug is undoubtedly effective in the prevention of IOP increases following phacoemulsification. IOPs recorded in patients treated with this drug were lower than those observed in the acetazolamide and the control groups. Considering the lower risk of toxicity associated with topical administration, apraclonidine 0.5% seems to be preferable to oral acetazolamide in this postoperative setting.

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“…Although it seems impossible to prevent IOP spikes completely, studies reported that IOP spikes were blunted with the use of antiglaucomatous agents. 13,18 It was shown that IOP spikes as high as 68 mmHg can develop after uneventful phacoemulsification cataract surgery in eyes without glaucoma or ocular hypetension. 19 It may be important at least to blunt IOP spikes.…”

Section: Discussionmentioning

confidence: 99%

“…9 Several antiglaucomatous agents have been used to control IOP after cataract surgery. 4,7,[10][11][12][13][14][15][16] In this prospective, randomized, doublemasked, controlled study, we evaluated the IOP-lowering effect of travoprost and brinzolamide within the first 24 h after phacoemulsification cataract surgery. To our knowledge, this is the first study to evaluate the effect of travoprost and brinzolamide to IOP after small incision phacoemulsification surgery.…”

Section: Introductionmentioning

confidence: 99%

Comparing the effects of travoprost and brinzolamide on intraocular pressure after phacoemulsification

Ermiş

Öztürk

İnan

2004

Eye

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Purpose To evaluate the intraocular pressure (IOP) lowering effect of travoprost and brinzolamide within the first 24 h after phacoemulsification cataract surgery. Methods This prospective, randomized, double-masked, controlled study comprised 90 eyes of 90 consecutive patients with senile cataract who had uneventful phacoemulsification surgery. Eyes in the first group received travoprost 0.0015%, second group received brinzolamide 1%. Eyes in the third group received balanced salt solution and were used as control. One drop was instilled immediately after surgery. IOP was measured 24 h preoperatively, 6 and 24 h postoperatively. Analysis of variance, Student's-t and w 2 -tests were used for statistical analyses. Results Preoperatively IOP was not significantly different among the three groups (P ¼ 0.653). At 6 and 24 h postoperatively IOP was lower in both travoprost and brinzolamide group when compared to control group (P ¼ 0.018 and 0.015 at 6 h, P ¼ 0.010 and 0.012 at 24 h, respectively). The difference between travoprost and brinzolamide group was not significant (P ¼ 0.859 at 6 h and P ¼ 0.581 at 24 h). Both travoprost and brinzolamide significantly reduced IOP increases when compared to control eyes at 6 and 24 h (P ¼ 0.036 and 0.029 at 6 h, P ¼ 0.010 and 0.007 at 24 h, respectively). The difference in IOP increase at 6 and 24 h between travoprost and brinzolamide group was not significant (P ¼ 0.744 at 6 h and P ¼ 0.672 at 24 h). Conclusion Both travoprost and brinzolamide significantly lowered IOP after small incision phacoemulsification cataract surgery within the first 24 h without any side effect.

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Comparison of the postoperative intraocular pressure with Betagan, Betoptic, Timoptic, Iopidine, Diamox, Pilopine Gel, and Miostat

Cited by 67 publications

References 19 publications

Ultrastructural Effects of Topical Beta-Adrenergic Antagonists and an Alpha-Adrenergic Agonist on the Rabbit Cornea

Ultrastructural Effects of Topical Beta-Adrenergic Antagonists and an Alpha-Adrenergic Agonist on the Rabbit Cornea

Comparative Efficacy of Acetazolamide and Apraclonidine in the Control of Intraocular Pressure following Phacoemulsification

Comparing the effects of travoprost and brinzolamide on intraocular pressure after phacoemulsification

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