Comparison of the Plasma Volume-Expanding Effects of 6% Dextran 70, 5% Albumin, and 6% HES 130/0.4 After Hemorrhage in the Guinea Pig

Abstract

After hemorrhage, the PV-expanding capacity of 6% dextran 70 was better than that of 5% albumin, which was in turn better than that of HES 130/0.4 given in equal volumes.

Hydroxyethyl starches and dextran during hip replacement surgery: effects on blood volume and coagulation

“…An infusion of colloid fluid provided an immediate expansion of blood volume that was, with the four preparations studied here, 20% larger than the infused volume 16 . As could be expected, the blood volume‐expanding effect faded with time.…”

Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig

“…It has been shown to have good PV expanding properties, in some studies even superior to that of all other colloids studied, in states of normal capillary permeability 18,19 and in states of increased capillary permeability. 20,21 Based on recent studies, the use of HES is no longer recommended in sepsis, 22 which has reduced the synthetic colloid treatment alternatives in the critically ill patients to a minimum.…”

Engineering Dextran-Based Scaffolds for Drug Delivery and Tissue Repair

“…Dextrans are commonly used to decrease vascular thrombosis [6,7], reduce inflammatory response [8] and prevent ischemia– reperfusion injury in organ transplantation [9–11], in which dextran acts as a mild reactive oxygen species scavenger and reduces excess platelet activation [12]. Dextran has volume expansive properties and therefore its inclusion can improve blood flow [13]. Occasionally, soluble dextran complexes can also be used to replace lost blood in emergency situations when replacement blood is not available [14].…”