Comparison of the Physical Stability of Astringent Hydrogels Based on Cellulose Derivatives

Vennat, B.; Gross, Denis; Pouget, M. P.; Pourrat, A; Pourrat, Henri

doi:10.3109/03639049509048123

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Hadi et al evaluated polyethylene glycol ointment bases for spreadability using a parallel-plate extensometer based on the sliding-plates design (Hdai et al, 1989). Later, Vennat et al validated the spreading-diameter measurements of hydrocreams on the basis of cellulose derivatives and established the linearity of spreadingdiameter measurement (Vennat et al, 1995;Panigrahi et al, 1997). The spreading capacity of the gel formulations was measured 48 h after preparation by measuring the spreading diameter of 1 g of the gel between two 20 × 20 cm glass plates after 1 min.…”

Section: Measurement Of Spreadabilitymentioning

confidence: 97%

Evaluation of mechanical and rheological properties of metronidazole gel as local delivery system

Jelvehgari

Montazam

2011

Arch. Pharm. Res.

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Rosacea is a chronic multifactorial vascular skin disorder that affects about 10 percent of the general population. Metronidazole is an effective antibiotic in the treatment of moderate-to severe rosacea. Metronidazole is a suitable drug in cases of resistance to tetracycline or erythromycin, but it has also been shown that oral metronidazole may increase the side effects (e.g., peripheral neuropathy). Oral metronidazole should not be used for more than three months, and hence topical metronidazole gel is the best therapeutic choice in rosacea (especially during pregnancy). This study examined the mechanical (adhesiveness, cohesiveness, extrudability, spreadability, homogeneity) and rheological (viscosity), skin irritant and drug release properties of different metronidazole gel formulations that contain anionic emulsifying wax, glycerin and lactic acid in different proportions. The release studies were conducted using Franz diffusion cells and Silastic membrane as a barrier. The results indicated that gel compressibility, hardness, and adhesiveness, are the factors that influence the ease of gel removal from the container, ease of gel application onto the mucosal membrane, and gel bioadhesion. The findings showed that there exists a strong negative correlation between the spreadability of a formulation and its cohesiveness, the spreadability of a formulation is inversely proportional to its cohesiveness. However, sorbitol solution (70%) concentration was not significantly correlated with drug release. In addition, drug release was significantly reduced as the concentration of anionic emulsifying wax increased and the concentration of lactic acid decreased. The maximum metronidazole release was achieved at a pH of 4-6. Data obtained from in vitro release studies were fitted to various kinetic models and high correlation was obtained in the Higuchi and first order models. The results showed that all the gel formulations showed good extrudability, viscosity, cohesiveness, homogeneity and spreadability.

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Section: Measurement Of Spreadabilitymentioning

confidence: 97%

Evaluation of mechanical and rheological properties of metronidazole gel as local delivery system

Jelvehgari

Montazam

2011

Arch. Pharm. Res.

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“…However, in one study the rheological stability of a series of cellulose ethers gels that contained Hamamelis was examined following storage under different light and temperature conditions. 28 The authors reported that following storage at 30°C, the viscosities of gels composed of methylcellulose, carboxymethylcellulose, or hydroxypropylmethylcellulose were dramatically affected. It is understood that cellulose derivatives, e.g., HPMC, HEC, may undergo oxidative depolymerization reactions in which free radicals may be formed by several mechanisms including hydrogen abstraction and electron transfer.…”

Section: Discussionmentioning

confidence: 99%

Rheological destructuring of aqueous gels composed of cellulose ethers following storage in the presence of redox agents

Jones

Muldoon

Woolfson

et al. 2005

J of Applied Polymer Sci

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ABSTRACT:Despite their widespread use, there is a paucity of information concerning the effect of storage on the rheological properties of pharmaceutical gels that contain organic and inorganic additives. Therefore, this study examined the effect of storage (1 month at either 4 or 37°C) on the rheological and mechanical properties of gels composed of either hydroxypropylmethylcellulose (3-5% w/w, HPMC) or hydroxyethylcellulose (3-5% w/w, HEC) and containing or devoid of dispersed organic (tetracycline hydrochloride 2% w/w) or inorganic (iron oxide 0.1% w/w) agents. The mechanical properties were measured using texture profile analysis whereas the rheological properties were analyzed using continuous shear rheometry and modeled using the Power Law model. All formulations exhibited pseudoplastic flow with minimal thixotropy. Increasing polymer concentration (3-5% w/w) significantly increased the consistency, hardness, compressibility, and adhesiveness of the formulations due to increased polymer chain entanglement. Following storage (1 month at 4 and 37°C) the consistency and mechanical properties of additive free HPMC gels (but not HEC gels) increased, due to the time-dependent development of polymer chain entanglements. Incorporation of tetracycline hydrochloride significantly decreased and increased the rheological and mechanical properties of HPMC and HEC gels, respectively. Conversely, the incorporation of iron oxide did not affect these properties. Following storage, the rheological and mechanical properties of HPMC and HEC formulations were markedly compromised. This effect was greater following storage at 37 than at 4°C and, additionally, greater in the presence of tetracycline hydrochloride than iron oxide. It is suggested that the loss of rheological/mechanical structure was due to chain depolymerization, facilitated by the redox properties of tetracycline hydrochloride and iron oxide. These observations have direct implications for the design and formulation of gels containing an active pharmaceutical ingredient.

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“…Spreadability, 11,12 spreading coefficiency and HPTLC 13 profiles of conventional forms were developed.…”

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confidence: 99%

Formulation Development and Preliminary Physico-Chemical Characterization of Kushtha Taila

Goriya¹,

Dhwani²,

Galib³

et al. 2014

Int. J. Res. Ayurveda Pharm.

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Importance of topical formulations in therapeutics has been noticed by the ancient seers. In suitable cases, they preferred topical medicaments along with internal medicaments. Kushtha taila is one such formulations of topical application advocated to be applied after incision of umbilical cord. Though the formulation is useful; its form poses certain inconveniences. Considering them, attempts were made to convert the oil form into certain conventional forms and develop their preliminary physico-chemical profiles. The raw material was procured from the Pharmacy, Gujarat Ayurved University and the excipients were purchased from Janak formulabs, Vatava, GIDC, Ahmadabad, India. Experiments were carried-out by following standard methods. Gel form was found to be more convenient in comparison to other conventional forms. All forms were found to possess antimicrobial properties. As these conventional forms are non-irritant, possess antibacterial and antifungal activities and are comparable to that of the standard drugs; the conventional forms (preferably gel) can replace the classical oil form. The therapeutic potential of such formulations may motivate researchers for further exploitation for their commercial viability.

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Comparison of the Physical Stability of Astringent Hydrogels Based on Cellulose Derivatives

Cited by 4 publications

References 5 publications

Evaluation of mechanical and rheological properties of metronidazole gel as local delivery system

Evaluation of mechanical and rheological properties of metronidazole gel as local delivery system

Rheological destructuring of aqueous gels composed of cellulose ethers following storage in the presence of redox agents

Formulation Development and Preliminary Physico-Chemical Characterization of Kushtha Taila

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