Comparison of the Outcomes after Intralesional, Intracisternal, and Intravenous Transplantation of Human Bone Marrow Derived Mesenchymal Stem Cells for Spinal Cord Injured Rat
Abstract:Objective: Mesenchymal stem cells (MSCs) have shown promise in potentially repairing injured spinal cord. These and similar cell types are being tested clinically, but the understanding about delivering method and subsequent results is lacking. This study was designed to compare the MSCs engraftment results after intralesional, intracisternal, or intravenous injection in a rat with spinal cord injury (SCI). Methods: A total of 48 male Sprague-Dawley rats (300-350 g in size) were used with 12 in each group. All… Show more
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