Comparison of the Outcome of Conventional in vitro Fertilization and Intracytoplasmic Sperm Injection in Moderate Male Infertility from Ejaculate

Xie, Baoguo; Huang, Yuanhua; Zhu, Weijie; Jin, Song

doi:10.1159/000353975

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…Moreover, important numbers of former cryptorchid patients are still being reported in the adult literature to be infertile despite successful orchidopexy [20] . In male factor infertility, pregnancy may be achieved by the use of assisted reproductive technology with limited success; however, the cost of male factor infertility treatment markedly exceeds the total cost of LHRHa treatment of a cryptorchid boy [19,21] .…”

Section: Discussionmentioning

confidence: 99%

Incidence of High Infertility Risk among Unilateral Cryptorchid Boys

Bilius¹,

Verkauskas²,

Dasevičius³

et al. 2015

Urol Int

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Background: Increasing evidence of progressive damage to germ cell development in boys with cryptorchidism suggests recommending surgery until one year of age. However, despite early and successful orchidopexy, cryptorchid boys with impaired mini-puberty will suffer from infertility. We reviewed changes in the timing of surgery during the past decade and the incidence of unilateral cryptorchid boys with defective mini-puberty. Methods: Medical registries were reviewed for all patients who were operated on for cryptorchidism at the main pediatric urological center of the country. The ages of surgery in cases of unilateral cryptorchidism were compared between the years 2000-2001 and 2012-2013. A high risk of infertility was considered when no Ad spermatogonia were found. Two groups were compared: group I - operated on until the age of 1.5 years and group II - older than 1.5 years. Results: The average age at operation decreased from 5.3 to 4.1 years. Forty-six biopsies in boys with unilateral cryptorchidism were made during orchidopexy on undescended testicles. Overall, 44% in group I and 50 % in group II (p > 0.05) had no Ad spermatogonia. Conclusions: The average age of operation for cryptorchidism has decreased, but remains far above the recommended age. The high prevalence of histologically proven risk of infertility underscores the necessity of more education regarding the importance of earlier surgery and the research on hormonal prevention of infertility.

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Section: Discussionmentioning

confidence: 99%

Incidence of High Infertility Risk among Unilateral Cryptorchid Boys

Bilius¹,

Verkauskas²,

Dasevičius³

et al. 2015

Urol Int

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“…A sibling oocyte RCT of IVF versus ICSI for couples undergoing their first treatment for moderate oligozoospermia failed to reveal any difference in pregnancy rates. 34 This was confirmed by a further RCT on patients attending their first IVF treatment for the same indication. 35 However, although research does not currently support the routine use of ICSI for even moderate degrees of oligozoospermia, substantial practice variations exist, with some laboratories routinely performing ICSI for every case of suspected male infertility.…”

Section: Semen Analysismentioning

confidence: 70%

Prognostic Factors for IVF Success: Diagnostic Testing and Evidence-Based Interventions

Papathanasiou

Bhattacharya

2015

Semin Reprod Med

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Numerous tests and interventions have been proposed for optimizing performance in preparation for in vitro fertilization (IVF) treatment. We critically appraised the available evidence underpinning some of the popular investigations and treatments, including the role of hysteroscopy, laparoscopy, ovarian reserve tests, sperm function tests, as well as the role of lifestyle modifications or surgery for endometriosis, fibroids, and endometrial polyps. We also reviewed the evidence behind novel techniques, such as the use of endometrial injury before IVF. Only a few of the aforementioned modalities are justified based on the available research evidence. Other factors may affect the uptake of a test or intervention before IVF, namely the complexity of the proposed modality, its potential for harm, and its cost-effectiveness.

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“…The decision of the best treatment option is more difficult in case of moderate oligozoospermia or oligoasthenozoospermia [ 106 ]. Shuai and colleagues demonstrated that moderate oligoasthenozoospermia does not negatively affect c-IVF clinical outcomes, such as fertilization, implantation and pregnancy rates, compared to ICSI treatment.…”

Section: Conventional Ivf and Male Gametesmentioning

confidence: 99%

Opportunities and Limits of Conventional IVF versus ICSI: It Is Time to Come off the Fence

Balli

Cecchele²,

Pisaturo³

et al. 2022

JCM

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Conventional IVF (c-IVF) is one of the most practiced assisted reproductive technology (ART) approaches used worldwide. However, in the last years, the number of c-IVF procedures has dropped dramatically in favor of intracytoplasmic sperm injection (ICSI) in cases of non-male-related infertility. In this review, we have outlined advantages and disadvantages associated with c-IVF, highlighting the essential steps governing its success, its limitations, the methodology differences among laboratories and the technical progress. In addition, we have debated recent insights into fundamental questions, including indications regarding maternal age, decreased ovarian reserve, endometriosis, autoimmunity, single oocyte retrieval-cases as well as preimplantation genetic testing cycles. The “overuse” of ICSI procedures in several clinical situations of ART has been critically discussed. These insights will provide a framework for a better understanding of opportunities associated with human c-IVF and for best practice guidelines applicability in the reproductive medicine field.

show abstract

Comparison of the Outcome of Conventional in vitro Fertilization and Intracytoplasmic Sperm Injection in Moderate Male Infertility from Ejaculate

Cited by 8 publications

References 20 publications

Incidence of High Infertility Risk among Unilateral Cryptorchid Boys

Incidence of High Infertility Risk among Unilateral Cryptorchid Boys

Prognostic Factors for IVF Success: Diagnostic Testing and Evidence-Based Interventions

Opportunities and Limits of Conventional IVF versus ICSI: It Is Time to Come off the Fence

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