Comparison of the Oral Absorption, Distribution, Excretion, and Bioavailability of Zinc Sulfate, Zinc Gluconate, and Zinc‐Enriched Yeast in Rats

Zhang, Shuang‐Qing; Yu, Xue‐Feng; Zhang, Haibo; Ning, Peng; Zhi-xian, Chen; Cheng, Qian; Zhang, Xiaoli; Cheng, Sui-Han; Zhang, Yan

doi:10.1002/mnfr.201700981

Cited by 19 publications

(14 citation statements)

References 17 publications

(33 reference statements)

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“…The spearheaded exploratory studies of Maage and co‐workers found that Glu‐Zn as dietary Zn sources has a positive effect on growth and body mineralization of Atlantic salmon ( Salmo salar ) (Maage et al, 2001). After, the biodistribution studies in rats demonstrated that Glu‐Zn has the equivalent bioavailable to Zn‐enriched yeast, but Glu‐Zn is absorbed faster than the Zn yeast (Zhang et al, 2018). Moreover, dietary administration of Glu‐Zn was found to improve the rats glycemic and inflammatory states (Elseweidy et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Luo

Wang

et al. 2021

Aquacult. Nutr.

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Zn is one of the essential elements to maintain normal fish metabolic process (including growth, development and reproduction), which have different chemical status in nature including inorganic, organic and nano‐sized. In this work, the efficacy of gluconic acid zinc (Glu‐Zn), nano zinc oxide (Nano ZnO), zinc sulphate (ZnSO4) on the growth performance, tissue mineral elements deposition, antioxidant activity and immune response of the tilapia fish Nile tilapia (Oreochromis niloticus) was evaluated. Three experimental diets were prepared by adding different forms of Zn sources (ZnSO4 as a control group) with same Zn concentration (40 mg/kg) and used to feed fish for 60 days. The biological trial results displayed that the growth performance of Nile tilapia has not obviously affected by different Zn form source supplement. However, Glu‐Zn and Nano ZnO supplements have significantly stimulated the Zn and Cu absorption deposition efficiency in the fish tissues as compared to ZnSO4 group. Besides, there was a significant increase in Cu‐Zn superoxide dismutase (35.03 U/mgprot), alkaline phosphatase (79.34 U/mgprot), aspartate aminotransferase (23.42 U/L), alanine aminotransferase (18.45 U/L), glutathione peroxidase (171.24 U/mgprot) and fatty acid synthase (11.55 ng/mL) content in Glu‐Zn treatment. Additionally, Glu‐Zn supply significantly increased serum lysozyme (9.91 U/mL), immunoglobulin M (0.48 g/L), complement 3 (0.74 g/L) and complement 4 (0.95 g/L) activity of Nile tilapia. Also, compared to ZnSO4 diet, lysozyme (11.44 U/mL) and complement 4 (0.63 g/L) content were obviously higher in fish fed Nano Zn diet. These findings revealed that supplementation with Glu‐Zn as a Zn source in feed is better than ZnSO4 for improving tissue mineralization, antioxidant stress, alleviate lipid peroxidation and immunity response of Nile tilapia. Meantime, Nano ZnO also played a positive role in the tissue mineralization and immunity response of Nile tilapia.

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Section: Introductionmentioning

confidence: 99%

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Luo

Wang

et al. 2021

Aquacult. Nutr.

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“…Sapota et al revealed that the rats administered zinc sulphate had the lowest Zn in the prostate tissue compared with those supplemented with zinc gluconate (42) . On the other hand, another in vivo study reported that zinc gluconate and zinc sulphate had equivalent bioavailability (43) . The second cause is study population; in one study administered zinc gluconate, subjects had Zn deficiency (34) .…”

Section: Discussionmentioning

confidence: 99%

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

et al. 2021

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Chronic inflammation has been considered as the main cause of chronic diseases. Zn has anti-inflammatory effects by decreasing the expression of inflammatory markers. The present systematic review and meta-analysis study aims to evaluate the impact of Zn supplementation on inflammation. Pubmed (Medline), Scopus, Web of Science, and Embase databases were searched up to December 10th, 2020. Randomized placebo-controlled trials have investigated the effects of Zn supplementation on serum/plasma levels of inflammatory cytokines in >15 years’ subjects were included. A pooled meta-analysis was performed using a random-effect model. Sensitivity analysis was performed to determine the robustness of the observed effect sizes. Potential causes of heterogeneity were determined using subgroup analyses. The relationship between effect size and co-variables was explored using meta-regression. In the cases of the presence of publication bias, trim and fill analysis was carried out. Cochrane Collaboration’s tool was used for assessing the quality of the included studies. A total of 12 studies was included in meta-analysis. Zn could decrease IL-6 levels (SMD= -0.76 pg/ml; 95% CI: -1.28, -0.24; P= 0.004). There was no significant change in TNF-α (SMD= 0.42 pg/ml; 95% CI: -0.31, 1.16; P= 0.257) and IL-2 levels (SMD= 1.64 pg/ml; 95% CI: -1.31, 4.59; P= 0.277) following Zn supplementation. However, Zn could increase IL-2 significantly after deletion of one arm in sensitivity analysis (SMD= 2.96 pg/ml; 95% CI: 2.03, 3.88; P< 0.05). Conclusively, Zn supplementation can decrease the IL-6 level. Zn increased IL-2 level after sensitivity analysis. Zn supplementation has not ameliorative effects on TNF-α.

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“…Optimization will require use of standardized animal models to control for host variables since the optimal Zn dose may relate to animal body size, skeletal site, target bone defect volume, and perhaps target defect bone area. Since Zn preferentially localizes to bone, 35 the optimal Zn dose may relate to available bone surface area to which the Zn may localize at the site of bone regeneration. Further optimization could involve choice of Zn salt used and choice of carriers to deliver Zn as a bolus dose or over an extended time depending on the target environment, such as treating a segmental defect versus promoting posterolateral spinal fusion.…”

Section: Discussionmentioning

confidence: 99%

Improved osteogenesis in rat femur segmental defects treated with human allograft and zinc adjuvants

Kanjilal

Grieg

Culbertson

et al. 2021

Exp Biol Med (Maywood)

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Bone allograft is widely used to treat large bone defects or complex fractures. However, processing methods can significantly compromise allograft osteogenic activity. Adjuvants that can restore the osteogenic activity of processed allograft should improve clinical outcomes. In this study, zinc was tested as an adjuvant to increase the osteogenic activity of human allograft in a Rag2 null rat femoral defect model. Femoral defects were treated with human demineralized bone matrix (DBM) mixed with carboxy methyl cellulose containing ZnCl2 (0, 75, 150, 300 µg) or Zn stearate (347 µg). Rat femur defects treated with DBM-ZnCl2 (75 µg) and DBM-Zn stearate (347 µg) showed increased calcified tissue in the defect site compared to DBM alone. Radiograph scoring and µCT (microcomputed tomography) analysis showed an increased amount of bone formation at the defects treated with DBM-Zn stearate. Use of zinc as an adjuvant was also tested using human cancellous bone chips. The bone chips were soaked in ZnCl2 solutions before being added to defect sites. Zn adsorbed onto the chips in a time- and concentration-dependent manner. Rat femur defects treated with Zn-bound bone chips had more new bone in the defects based on µCT and histomorphometric analyses. The results indicate that zinc supplementation of human bone allograft improves allograft osteogenic activity in the rat femur defect model.

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Comparison of the Oral Absorption, Distribution, Excretion, and Bioavailability of Zinc Sulfate, Zinc Gluconate, and Zinc‐Enriched Yeast in Rats

Abstract: ZnS, ZnG, and ZnY show equivalent bioavailability based on plasma and tissues zinc levels, although ZnY was statistically more absorbed and retained than ZnS and ZnG based on the excretion amount.

Cited by 19 publications

References 17 publications

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

Improved osteogenesis in rat femur segmental defects treated with human allograft and zinc adjuvants

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