Comparison of the Oncological and Renal Function Outcomes of Partial Ureterectomy and Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma: a Meta-analysis

Abstract

Background To perform a meta-analysis of comparative studies reporting oncological and renal function outcomes of of partial ureterectomy and radical nephroureterectomy in upper tract urothelial carcinoma (UTCC). Methods A literature search of PubMed, Embase, and the Cochrane library was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, and a meta-analysis was performed to assess cancer-specific survival (CSS), overall survival (OS), recurrence-free survival (RFS), and perioperative variations in the estimated glomerular filtration rate (eGFR). Results Nineteen studies involving 4940 patients were included in our meta-analysis. No significant differences were found in the 5-year OS (HR=1.20, p=0.40), 5-year RFS (HR=1.21, p=0.37) and CSS (HR=0.89, p=0.20). A better preservation of renal function of PU compared with RNU changes in (eGFR) (WMD=-9.75, p=0.0006) between the patients undergoing the two types of surgery. Conclusions PU could achieve equal oncological outcomes and better postoperative renal function than RNU.