2005
DOI: 10.11150/kansenshogakuzasshi1970.79.521
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Comparison of the Number of Norovirus Genome Copies in Patients and Healthy Persons

Abstract: In viral gastroenteritis outbreaks occurred by Norovirus (NV), NV was detected not only from patients but also from healthy persons who have taken the same food, and also detected from healthy staff members working at community places such as hospital, school and nursing home. The number of fecal NV genome copies of patients, healthy persons and food handlers are examined by real-time PCR method, to investigate foodborne gastroenteritis and person to person transmission outbreaks. There is no significant diffe… Show more

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Cited by 4 publications
(4 citation statements)
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“…Here, real‐time PCR was employed for high‐specificity detection of norovirus from clinical specimens. No significant difference was observed between patients and asymptomatic carriers with the respect to the rate of norovirus‐IgA complex region/total number of norovirus using the non‐parametric Mann‐Whitney u test, and in terms of norovirus copy numbers by using t ‐test, which is consistent with previous reports . Nevertheless, it should be noted that aggregated or assembled virus particles in fecal specimens, which seemed to bind to antibodies, had sometimes been observed by electron microscopy examination .…”
Section: Discussionsupporting
confidence: 90%
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“…Here, real‐time PCR was employed for high‐specificity detection of norovirus from clinical specimens. No significant difference was observed between patients and asymptomatic carriers with the respect to the rate of norovirus‐IgA complex region/total number of norovirus using the non‐parametric Mann‐Whitney u test, and in terms of norovirus copy numbers by using t ‐test, which is consistent with previous reports . Nevertheless, it should be noted that aggregated or assembled virus particles in fecal specimens, which seemed to bind to antibodies, had sometimes been observed by electron microscopy examination .…”
Section: Discussionsupporting
confidence: 90%
“…No significant difference was observed between patients and asymptomatic carriers with the respect to the rate of norovirus-IgA complex region/total number of norovirus using the non-parametric Mann-Whitney u test, and in terms of norovirus copy numbers by using t-test, which is consistent with previous reports. 2,3 Nevertheless, it should be noted that aggregated or assembled virus particles in fecal specimens, which seemed to bind to antibodies, had sometimes been observed by electron microscopy examination. 10 Indeed, acquired norovirus-specific antibodies in serum and IgA antibodies in breast milk were previously reported, 11,12 but information on fecal IgAs was limited.…”
Section: Discussionmentioning
confidence: 99%
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“…Both NoV and SaV infect humans via the fecal-oral route and cause family or community-wide outbreaks, mainly in the winter season. NoVs are shed in feces at a level of 10 5 to 10 9 virus particles per gram during the symptomatic phase (32,37), and viruses are continuously shed from patients after cessation of the symptoms (28,37,40). In addition, recent reports showed relatively high levels of shedding of the viruses from asymptomatic individuals (7,8,32,37).…”
mentioning
confidence: 99%