Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes

Han, Jung Woo; Choi, Juhye; Kim, Young S.; Kim, Jina; Brinkmann, Ralf; Lyu, Jiao; Park, Tae Kwann

doi:10.1007/s00417-017-3883-7

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…Four days after SRT, irregular shaped cells with conspicuous nuclei covered the laser-induced RPE wound (b). Some of these enlarged cells showed two nuclei (arrow), which suggest mitosis nificantly lower levels after SRT than in LPC [43]. It has also been shown that matrix metalloproteinases (MMPs), particularly the active form of MMP-2 is significantly upregulated [39,40,44] and also locally resolved as shown in Fig.…”

Section: Resultsmentioning

confidence: 85%

Selective Retina Therapy

Považay

Brinkmann

Stoller³

et al. 2019

High Resolution Imaging in Microscopy and Ophthalmology

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Section: Resultsmentioning

confidence: 85%

Selective Retina Therapy

Považay

Brinkmann

Stoller³

et al. 2019

High Resolution Imaging in Microscopy and Ophthalmology

Self Cite

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“…AMD treatment is diverse, involving neurotrophic factors, growth factors, cell viability factors, and also oxidative stress-preventing factors [ 2 , 29 , 30 , 31 ]. With the wet AMD, vascular endothelial growth factor (VEGF) inhibitors and the photodynamic therapy are mainly used [ 32 , 33 ]. Despite efforts aimed at developing adequate therapy, the challenges associated with the treatment of AMD to preserve vision are still substantial.…”

Section: Brief Characteristics Of the Major Degenerative Disorders Of...mentioning

confidence: 99%

Cell Sources for Retinal Regeneration: Implication for Data Translation in Biomedicine of the Eye

Grigoryan

2022

Cells

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The main degenerative diseases of the retina include macular degeneration, proliferative vitreoretinopathy, retinitis pigmentosa, and glaucoma. Novel approaches for treating retinal diseases are based on cell replacement therapy using a variety of exogenous stem cells. An alternative and complementary approach is the potential use of retinal regeneration cell sources (RRCSs) containing retinal pigment epithelium, ciliary body, Müller glia, and retinal ciliary region. RRCSs in lower vertebrates in vivo and in mammals mostly in vitro are able to proliferate and exhibit gene expression and epigenetic characteristics typical for neural/retinal cell progenitors. Here, we review research on the factors controlling the RRCSs’ properties, such as the cell microenvironment, growth factors, cytokines, hormones, etc., that determine the regenerative responses and alterations underlying the RRCS-associated pathologies. We also discuss how the current data on molecular features and regulatory mechanisms of RRCSs could be translated in retinal biomedicine with a special focus on (1) attempts to obtain retinal neurons de novo both in vivo and in vitro to replace damaged retinal cells; and (2) investigations of the key molecular networks stimulating regenerative responses and preventing RRCS-related pathologies.

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“…On the other hand, the clinical efficacy of the neuroprotective strategies has not been firmly established. Furthermore, surgical interventions like laser therapies may not prevent the progression of the disease in patients with AMD or other RD and can cause inflammatory-related damages[ 37 - 39 ].…”

Section: Retinal Degenerations and Treatmentsmentioning

confidence: 99%

Retina stem cells, hopes and obstacles

German

Vallese-Maurizi

Soto

et al. 2021

WJSC

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Retinal degeneration is a major contributor to visual dysfunction worldwide. Although it comprises several eye diseases, loss of retinal pigment epithelial (RPE) and photoreceptor cells are the major contributors to their pathogenesis. Early therapies included diverse treatments, such as provision of anti-vascular endothelial growth factor and many survival and trophic factors that, in some cases, slow down the progression of the degeneration, but do not effectively prevent it. The finding of stem cells (SC) in the eye has led to the proposal of cell replacement strategies for retina degeneration. Therapies using different types of SC, such as retinal progenitor cells (RPCs), embryonic SC, pluripotent SCs (PSCs), induced PSCs (iPSCs), and mesenchymal stromal cells, capable of self-renewal and of differentiating into multiple cell types, have gained ample support. Numerous preclinical studies have assessed transplantation of SC in animal models, with encouraging results. The aim of this work is to revise the different preclinical and clinical approaches, analyzing the SC type used, their efficacy, safety, cell attachment and integration, absence of tumor formation and immunorejection, in order to establish which were the most relevant and successful. In addition, we examine the questions and concerns still open in the field. The data demonstrate the existence of two main approaches, aimed at replacing either RPE cells or photoreceptors. Emerging evidence suggests that RPCs and iPSC are the best candidates, presenting no ethical concerns and a low risk of immunorejection. Clinical trials have already supported the safety and efficacy of SC treatments. Serious concerns are pending, such as the risk of tumor formation, lack of attachment or integration of transplanted cells into host retinas, immunorejection, cell death, and also ethical. However, the amazing progress in the field in the last few years makes it possible to envisage safe and effective treatments to restore vision loss in a near future.

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Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes

Cited by 6 publications

References 37 publications

Selective Retina Therapy

Selective Retina Therapy

Cell Sources for Retinal Regeneration: Implication for Data Translation in Biomedicine of the Eye

Retina stem cells, hopes and obstacles

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