Comparison of the most common isolates of postoperative endophthalmitis in South Korea; Enterococcus species vs coagulase-negative staphylococci

Nam, Ki Yup; Kim, Hyun Wong; Jeung, Woo Jin; Park, Jung Min; Park, Jong; Chung, In‐Young; Han, Yong Seop; Oum, Boo Sup; Lee, Ji Eun; Byon, Ik Soo; Yun, Il Han; Lee, Joo Eun; Yoon, Hyong Seo; Park, Dong; Yu, Byeng Chul; Lee, Sang Joon

doi:10.1186/s12879-016-2038-5

Cited by 7 publications

(9 citation statements)

References 14 publications

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“…E. faecalis, a relatively rare cause of endophthalmitis, is identified as a pathogen in both exogenous and endogenous etiologies. Exogenous E. faecalis endophthalmitis is primarily caused by trauma and post-surgery, such as cataract extraction, trabeculectomy, penetrating keratoplasty, vitrectomy, and intravitreal injection [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. E. faecalis accounted for approximately 1% of culture-positive acute post-cataract surgery endophthalmitis cases in the Endophthalmitis Vitrectomy Study [5,6].…”

Section: Introductionmentioning

confidence: 99%

Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

et al. 2021

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Enterococcus faecalis is known to cause severe acute endophthalmitis and often leads to poor visual outcomes in most ophthalmic infections. This retrospective study is to report the clinical settings, antimicrobial susceptibility patterns, and visual outcome of E. faecalis endophthalmitis at a tertiary referral institution in Taoyuan, Taiwan. E. faecalis endophthalmitis was diagnosed in 37 eyes of 37 patients. Post-cataract surgery was the most common cause (n = 27, 73%), followed by bleb-associated (n = 3, 8%), endogenous (n = 2, 5%), corneal ulcer-related (n = 2, 5%), post-vitrectomy (n = 1, 3%), post-pterygium excision (n = 1, 3%), and trauma (n = 1, 3%). Visual acuities upon presentation ranged from counting fingers to no light perception. Pars plana vitrectomy with intravitreal antibiotics were performed in 23 eyes (76%) as primary or secondary treatment. All isolates (37/37, 100%) were sensitive to vancomycin, penicillin, ampicillin, and teicoplanin. Six of 22 eyes (27%) were resistant to high-level gentamicin (minimum inhibitory concentration > 500 mg/L). Final visual acuities were better than 20/400 in 11 eyes (30%), 5/200 to hand motions in 4 eyes (11%), and light perception to no light perception in 22 eyes (59%). Three eyes were treated with evisceration. Compared with non-cataract subgroups, the post-cataract subgroup showed a significant difference of better visual prognosis (p = 0.016).

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Section: Introductionmentioning

confidence: 99%

Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

et al. 2021

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“…This means that infections that caused by CNS are less severe than other bacterial types. However, some people may experience serious infections associated with CNS [11]. In the case of this report, failure to early treat the causative bacteria had resulted in infection and other complications such as osteomyelitis.…”

Section: Discussionmentioning

confidence: 77%

Postoperative Infection Caused by Methicillin-Resistant Coagulase- Negative Staphylococci in the Oral and Maxillofacial Region: A Case Report

Lee

You

2020

JOMP

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Osteomyelitis of the jaw infected with Coagulase-Negative Staphylococci (CNS) is rarely reported in the Oral and Maxillofacial Region. Staphylococcus is a part of the normal body flora, but it may be cause severe infections and CNS are often described as the important pathogens in nosocomial infections. Although many studies on prevalence and antibiotics of Staphylococcus aureus have been done, but many of these studies focus only on Methicillin-resistant S. aureus and not on methicillin-resistant coagulase-negative Staphylococci (MRCNS). There was a less study about CNS or MRCNS infections in the Oral and Maxillofacial Region. This report describes a case of a 41-year-old male patient who developed osteomyelitis caused by MRCNS on condyle after open reduction and internal fixation and suggests guideline for the prevention of postoperative infection and appropriate recommendation for treatment and control.

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“…Of concern, the increase of Enterococcus spp. isolate in PE has poor impact on the visual outcome of endophthalmitis [ 3 , 4 , 11 , 12 , 29 ]. To address this challenge, various efforts will be needed in the near future.…”

Section: Discussionmentioning

confidence: 99%

Emerging Enterococcus isolates in postoperative endophthalmitis by selection pressure of fluoroquinolones: an 11-year multicenter and experimental study

Kim

Nam

Chung

et al. 2020

Emerging Microbes & Infections

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Postoperative endophthalmitis (PE) is the devastating complication that frequently results in vision loss. Recently, enterococcus have emerged as a major cause of PE in several countries and resulted in poor visual outcome. However, the reason remains elusive. We investigate whether selection pressure of fluoroquinolone exerts effects on microorganism profiles isolated from PE. Medical records of patients who were diagnosed with PE at eight resident training institutions between January 2004 and December 2015 were reviewed. The most common isolate was Enterococcus faecalis (28.0%), followed by Staphylococcus epidermidis (18.6%) and other coagulase negative Staphylococci (7.6%). However, the rates of E. faecalis isolated from conjunctival microbes were 6.2% (16/257) and their resistance to fluoroquinolones was higher than those of S. epidermidis. In vitro and in vivo co-culture models of E. faecalis and S. epidermidis were established for survival assays after administration of fourth-generation fluoroquinolone. In in vitro co-culture model, the survival assay of E. faecalis and S. epidermidis against the treatment of moxifloxacin showed that E. faecalis survived significantly better than S. epidermidis in the presence of moxifloxacin 1 µg/mL and more. In in vivo co-culture model, E. faecalis survived significantly better than S. epidermidis after topical treatment of moxifloxacin (5 mg/mL). E. faecalis has been the most common causative strain of PE in Korea. We suggest that the increase of E. faecalis in PE could be associated with the selection pressure of fourth-generation fluoroquinolone. Summary: Enterococcus spp. have emerged as a leading causative strain of postoperative endophthalmitis in 11-year clinical data. We suggest that the increase of Enterococcus spp. is associated with the selection pressure of fourthgeneration fluoroquinolone.

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Comparison of the most common isolates of postoperative endophthalmitis in South Korea; Enterococcus species vs coagulase-negative staphylococci

Cited by 7 publications

References 14 publications

Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

Postoperative Infection Caused by Methicillin-Resistant Coagulase- Negative Staphylococci in the Oral and Maxillofacial Region: A Case Report

Emerging Enterococcus isolates in postoperative endophthalmitis by selection pressure of fluoroquinolones: an 11-year multicenter and experimental study

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