Comparison of the migration behavior of nanoparticles based on polyethylene glycol and silica using micellar electrokinetic chromatography

Abstract

Nanoparticles, spherical particles with diameters less than 100 nm, are promising theranostic devices for noninvasive diagnosis and therapy. In this study, nanoparticles composed of polyethylene glycol and silica were prepared, and their migration behavior was examined using capillary electrophoresis. The effects of the sodium dodecyl sulfate concentration in the electrolyte, the nanoparticle size, and the encapsulated molecule on the migration were examined. The addition of sodium dodecyl sulfate into the electrolyte had a significant effect on the electrophoretic mobility of polyethylene glycol nanoparticles, but a small effect on that of silica nanoparticles. As for the size effect, the mobility became a little faster for smaller nanoparticle sizes for both polyethylene glycol and silica nanoparticles. The encapsulated molecule affected the mobility of the nanoparticles through interactions between the encapsulated molecules and sodium dodecyl sulfate. We propose that the large effect of sodium dodecyl sulfate on the migration of the polyethylene glycol nanoparticles was due to the large spaces within the nanoparticles. These results indicate that nanoparticle migration is mainly determined by the nanoparticle components.

Capillary Electrophoresis

“…Kato et al prepared silica and polyethylene glycol nanoparticles to study their migration behavior in CE. 208 Although their diameters are similar in size, migration behavior was found to be different. Studies varying SDS concentration determined differences in migration were due to nanoparticle structure and not size.…”

“…Kato et al prepared silica and polyethylene glycol nanoparticles to study their migration behavior in CE . Although their diameters are similar in size, migration behavior was found to be different.…”

Rapid and mild purification method for nanoparticles from a dispersed solution using a monolithic silica disk

“…Silica nanoparticles containing rhodamine were prepared by means of a reported method [16,19,20]. Arginine (10 mg) and rhodamin 110 (1 g) were dissolved in 10 mL of deionized water, and then 0.45 mL of cyclohexane and 0.55 mL of TEOS were added to the solution.…”

Surfactant-free aqueous preparation from a star polymer of size-controlled nanoparticles with encapsulated functional molecules

“…Dynamic light scattering measurement was performed using a similar procedure to that described in a previous paper by the authors. 25 A Nanotrac Wave dynamic light scattering (DLS) instrument (Microtrac BEL Corp., Osaka, Japan) was used to measure the diameters of the nanoparticles, with all measurements being carried out room temperature using a 780 nm laser beam. At least three replicates were performed for each sample using 20 mL of sample solution each time.…”