Comparison of the Metabolic Stimulating Action of Aspirin and Thyroid

A comparison of sodium salicylate and 2:4-dinitrophenol as metabolic stimulants in vitro

“…This is of interest, but it should be borne in mind that the data refer in each case to an unspecified part of the whole concentrationresponse curve. In contrast with the present findings, Alexander & Johnson (1956) found that a simple linear relation between serum concentration of salicylate and metabolic rate under basal conditions adequately accounted for their results…”

Salicylates and Thyroid Function. I. Depression of Thyroid Function

“…The coefficient of correlation (r) is 0.72 (p < 0.01). A similar relationship has been observed in rabbits (6) and in patients with myxedema (32). The two patients, C. M. and L. E., whose mean salicylate concentrations were 65 and 58 mg. per 100 ml., respectively, were lethargic and failed to show a rise in oxygen consumption proportional to their serum salicylate concentration; their points lie to the right of the regression line shown in Figure the metabolic stimulation for a given serum salicylate concentration was greater during the first 3 to 10 days than during subsequent chronic administration and points obtained during this period fall to the left of the regression line.…”