Comparison of the metabolic and ventilatory response to hypoxia and H2S in unsedated mice and rats

Haouzi, Philippe; Bell, Harold J.; Notet, Véronique; Bihain, Bernard E.

doi:10.1016/j.resp.2009.06.006

Cited by 54 publications

(32 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in the control group excessive renal damage led to an impaired 3 day survival of only 30%, whereas in groups pre-treated with H 2S 100% survived the IRI [125]. The applicability of H2S-induced hypometabolism in larger animals is dubious [105,120,[126][127][128][129]. However, hypometabolism can be induced in isolated organs of larger species.…”

Section: Protective Properties Of H2s In Renal Iri and Transplantationmentioning

confidence: 99%

Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

et al. 2015

View full text Add to dashboard Cite

Section: Protective Properties Of H2s In Renal Iri and Transplantationmentioning

confidence: 99%

Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

et al. 2015

View full text Add to dashboard Cite

“…One would expect that administration of gaseous H 2 S would achieve the opposite result of those seen with HSSI. However, gaseous H 2 S administration has also been found to reduce the ventilatory response to hypoxia [19] . These counterintuitive findings indicate that pharmacologic modulation of H 2 S synthesis is complex, and further research is needed to elucidate the systemic effects of HSSI on H 2 S levels at the loci of chemosensitivity and respiratory control.…”

Section: Discussionmentioning

confidence: 99%

“…Hypoxia-induced anapyrexia is thought to be caused by a change in hypothalamic set point [19] , and it is possible that effects at the level of the hypthalamus contributed to both the hypoxic ventilatory response in the AOAA treatment group and the ability of the two systemically administered drugs to enhance hypoxia-induced anapyrexia.…”

Section: Discussionmentioning

confidence: 99%

Effects of Hydrogen Sulfide Synthesis Inhibitors on Posthypoxic Ventilatory Behavior in the C57BL/6J Mouse

et al. 2011

View full text Add to dashboard Cite

Background: H2S synthesis inhibitors (HSSI) have been shown to impact respiratory control. For instance, the HSSI hydroxylamine (HA) decreases the respiratory discharge rate from isolated medullary sections, and HA in addition to other HSSIs propargylglycine and amino-oxyacetic acid (AOAA) have been found to reduce hypoxic responsiveness. Objectives: The aim of this study was to determine if administration of HSSIs could improve respiratory stability in an intact organism prone to recurrent central apneas. Methods: Saline and HSSI compounds were administered to C57BL/6J mice (n = 24), a strain predisposed to recurrent central apneas, prior to measurement of hypoxic and posthypoxic ventilatory behavior. Results: Administration of HA and AOAA resulted in a significantly smaller percentage of animals expressing one or more apneas during reoxygenation compared to saline control, and animals given AOAA demonstrated a smaller coefficient of variation for frequency during reoxygenation, a marker suggesting greater respiratory stability. This occurred despite varying effects of the three HSSI compounds on hypoxic ventilatory response. Conclusions: Instability and pause expression are improved by targeting H2S synthesis, an effect not predicted by effects on hypoxic responsiveness.

show abstract

“…However, the use of H2S in larger animals such as pigs [67][68][69][70], sheep [65], and heavy rats [71] has failed to induce a hypometabolic response (Figure 8, inner ring). The current mechanistic paradigm of the hypometabolic effect of H2S is based on its high membrane permeability and direct inhibitory effect on cytochrome c oxidase in the electron transport chain (i.e., through the Rx-A relationship) [72,73].…”

Section: Hydrogen Sulfidementioning

confidence: 99%

The physiology of artificial hibernation

Heger

2015

JCTRes

View full text Add to dashboard Cite

Incomplete understanding of the mechanisms responsible for induction of hibernation prevent translation of natural hibernation to its artificial counterpart. To facilitate this translation, a model was developed that identifies the necessary physiological changes for induction of artificial hibernation. This model encompasses six essential components: metabolism (anabolism and catabolism), body temperature, thermoneutral zone, substrate, ambient temperature, and hibernation-inducing agents. The individual components are interrelated and collectively govern the induction and sustenance of a hypometabolic state. To illustrate the potential validity of this model, various pharmacological agents (hibernation induction trigger, delta-opioid, hydrogen sulfide, 5'-adenosine monophosphate, thyronamine, 2-deoxyglucose, magnesium) are described in terms of their influence on specific components of the model and corollary effects on metabolism. Relevance for patients: The ultimate purpose of this model is to help expand the paradigm regarding the mechanisms of hibernation from a physiological perspective and to assist in translating this natural phenomenon to the clinical setting.

show abstract

Comparison of the metabolic and ventilatory response to hypoxia and H2S in unsedated mice and rats

Cited by 54 publications

References 35 publications

Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

Effects of Hydrogen Sulfide Synthesis Inhibitors on Posthypoxic Ventilatory Behavior in the C57BL/6J Mouse

The physiology of artificial hibernation

Contact Info

Product

Resources

About