Comparison of the Lamina Cribrosa Thickness of Patients With Unilateral Branch Retinal Vein Occlusion and Healthy Subjects

Lim, Su-Ho; Kim, Mirae; Chang, Woo Hyok; Sagong, Min

doi:10.1097/iae.0000000000001175

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…Our findings were consistent with previous findings, which indicated that there are similarities in the changes in the parapapillary area and ONH between patients with BRVO and glaucoma. [3][4][5][6][7][8] The finding of significant thinning of the mean PCT in the eyes with focal LC defects in both the BRVO and glaucoma groups supports the hypothesis that vascular insufficiency is, to some extent, involved in the pathophysiology of these two diseases. The short posterior ciliary artery (SPCA) supplies blood to the posterior choriocapillaries, from the macular to the equator and the peripapillary areas.…”

Section: Plos Onesupporting

confidence: 61%

“…If both BRVO and glaucoma share a common pathophysiologic change that affects the parapapillary area and the ONH, the findings of previous studies can also be explained more easily. [3][4][5][6][7][8] However, further prospective studies are needed to determine the specific pathophysiologic mechanism associated with peripapillary choroidal change and focal LC defects in patients with BRVO.…”

Section: Plos Onementioning

confidence: 99%

“…[5] Subsequent studies have further investigated changes in the optic nerve head (ONH) region, especially the lamina cribrosa (LC), in patients with BRVO. [6,7] These studies found that significant reductions in LC thickness occur in the eyes of patients with BRVO. One study used optical coherence tomography angiography (OCTA) to evaluate changes in peripapillary microvasculature parameters in the fellow eyes of the patients with unilateral RVO.…”

Section: Introductionmentioning

confidence: 99%

“…Taken together, these study results indicate that the changes in the peripapillary choroid and ONH are similar between patients with BRVO and patients with glaucoma. [3][4][5][6][7][8] Thus, our hypothesis was that BRVO and glaucoma may share a common pathophysiology that results in these similarities.…”

Section: Introductionmentioning

confidence: 99%

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Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion

et al. 2020

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To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG). Methods This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). In addition to baseline characteristics such as age, sex, refractive errors, the ocular characteristics such as peripapillary choroidal thickness (PCT), retinal nerve fiber layer thickness, and subfoveal choroidal thickness were retrospectively analyzed. Results Focal LC defects were detected in 20 eyes of 14 patients (38.9%) in the BRVO group, 24 eyes of 15 patients (41.7%) in the NTG group, and none in the control group (P<0.001). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the BRVOaffected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the NTG group, the mean PCT was 133.1±48.9 μm in the eyes with focal LC defects and 170.8±81.9 μm in those without (P = 0.042). The other baseline and ocular characteristics were not significantly different between the eyes with and without focal LC defects in both the BRVO group and the NTG group.

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Section: Plos Onesupporting

confidence: 61%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion

et al. 2020

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“…First, the number of study subjects was limited. Second, we did not include BRVO patients with occlusions at the optic disc (although the prevalence is considered to be relatively lower than that of BRVO occurring at AV crossings) 37 or patients with poor visual function due to severe BRVO. Therefore, the current findings may not be generalizable to all types of BRVO.…”

Section: Discussionmentioning

confidence: 99%

Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography

Kogo

Muraoka

Iida

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Kogo T, Muraoka Y, Iida Y, et al. Angiographic risk features of branch retinal vein occlusion onset as determined by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2020;61(2):8. https://doi.org/10.1167/iovs.61.2.8 PURPOSE.Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). METHODS.We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-or second-order branches of the retinal veins associate, using a viewing angle of 12 × 12 mm 2 in optical coherence tomography angiography (OCTA). RESULTS.We reviewed 1349 and 1276 AV crossings in BRVO patients and control subjects, respectively. The proportions of venous overcrossing were 26.5%, 28.6%, and 26.8% at non-causative crossings in BRVO eyes, non-BRVO fellow eyes, and unaffected control eyes, respectively; however, the rate of venous overcrossings at the causative crossings was 45.1%. In OCTA analyses, we divided the branches into macular-or non-macular veins. The rate of venous overcrossing was 52.5% at causative crossings in major BRVO but was 28.6% in macular BRVO. Odds ratios for whether venous overcrossing was a risk factor for BRVO were 3.09 (95% confidence interval [CI], 1.96-4.88) and 0.94 (95% CI, 0.44-2.00) for non-macular veins and macular veins, respectively. The patients with major BRVO caused by venous overcrossing were younger than patients for whom the cause was arterial overcrossing (P < 0.001). The onset of macular BRVO did not differ between crossing patterns at causative crossings (P = 0.60). CONCLUSIONS.In eyes with BRVO, venous overcrossing was a common angiographic feature at causative crossings and might be a risk factor for major BRVO onset.

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Evaluation of lamina cribrosa thickness in patients diagnosed with central retinal vein occlusion

Altunel¹,

Ataş

Demircan

2019

Graefes Arch Clin Exp Ophthalmol

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Comparison of the Lamina Cribrosa Thickness of Patients With Unilateral Branch Retinal Vein Occlusion and Healthy Subjects

Abstract: A thinner LC was observed in both eyes of unilateral BRVO patients compared with those of healthy subjects. This finding suggests that thin LC may contribute to the pathogenesis of BRVO as a local mechanical factor in addition to systemic factors.

Cited by 11 publications

References 23 publications

Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion

Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion

Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography

Evaluation of lamina cribrosa thickness in patients diagnosed with central retinal vein occlusion

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