Comparison of the Lamina Cribrosa in Mammalian Species With Good and With Indifferent Vision

Tansley, Katharine

doi:10.1136/bjo.40.3.178

Cited by 41 publications

(12 citation statements)

References 3 publications

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“…However, although his description of the optic nerve was present in a major textbook of anatomy of the eye and orbit (Wolf 1940), this information is now largely ignored. In addition, although connective tissue may be present at the rodent lamina cribrosa, where the fascicular configuration of the nerve is established, its concentration at this location appears to be relatively low (Tansley 1956). These animals are unusual in that they are one of the few mammalian types that lack connective tissue in the extra-fascicular matrix of their optic nerves (Jeffery, in preparation), and consequently, they do not have the distinctive fascicular configuration seen in other mammals, where there is a clear separation between the majority of fascicles (Reese 1987, rat;Wilbrand and Saenger 1902, man;Baker 1990, ferret;Evans and Jeffery 1992, cat;Harman and Jeffery 1992, wallaby).…”

Section: Discussionmentioning

confidence: 99%

“…They found that types V and VI appeared more filamentary than the other collagens, again in agreement with results presented here. Evidence in favour of this comes from the finding that connective tissue is absent from the rat optic nerve (Jeffery, in preparation) and was not identified at the light microscope level at the lamina cribrosa (Tansley 1956). Types I and III have been shown to be codistributed in several tissues including throughout the dermis of the human skin (Vitarello-Zuccarello et al 1992) supporting earlier studies that suggest the existence of types I and III within the same fibre (Keene et al 1987).…”

Section: Discussionmentioning

confidence: 99%

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The human optic nerve: fascicular organisation and connective tissue types along the extra-fascicular matrix

et al. 1995

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Fibres in the mammalian optic nerve are arranged into fascicles between which there is an extra-fascicular matrix containing connective tissue, a feature similar to that found in association with fibres in peripheral nerves, but not otherwise found in the CNS. The relationship between these major features of the nerve architecture are not known. We have addressed this question by examining the fascicular organisation of the optic nerve and the distribution of connective tissue and specific collagen types in the human. We have also examined the spatial development of connective tissue in the human nerve to determine when and from where it originates. Fibres are grouped into fascicles at all locations along the nerve, except intracranially, close to the chiasm where this pattern is lost. Relatively large fascicular numbers are found directly behind the eye and in the region of the optic canal, but decline in the mid-orbital segment of the nerve. Connective tissue is present in the extra-fascicular matrix throughout the fasciculated segment, but in many cases it does not fully encircle fascicles. The proportion of matrix occupied by connective tissue is similar along the length of the nerve (approximately 60%). Within the matrix, collagen types I, III, IV, V and VI are present throughout fasciculated regions. Staining for types V and VI appeared relatively weak compared with that for the other types. Although the collagen types in the nerve are similar to those at the lamina cribrosa and in peripheral nerves, they did not appear to be differentially distributed as in regions of the PNS. Connective tissue enters the nerve at a number of wide-spread locations early in development, consistent with the notion that it enters the nerve with the blood supply. It is present within the matrix before it is established at the lamina cribrosa.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The human optic nerve: fascicular organisation and connective tissue types along the extra-fascicular matrix

et al. 1995

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“…Occasionally a cap¬ illary was seen to reach deeper. Lon¬ gitudinal branching was not seen and the axial descending branches of cap¬ illaries more central in the nerve did Submitted for publication Jan 10,1973 There have been few published studies of optic nerve capillaries. Sev¬ eral investigators described the capil¬ laries of normal human optic nerves, visualized by benzidine staining.…”

Section: Resultsmentioning

confidence: 99%

Capillaries of Rat Optic Nerve

Lessell¹

1974

Arch Ophthalmol

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“…1938;Tansley, 1956]. Figure 1 in the paper of Nicholls and Tansley [ 1938] shows a sagittal section of a rat eye with an identifiable LC, in contrast to other rat eyes shown in figures 2-4.…”

Section: Discussionmentioning

confidence: 99%

The Lamina cribrosa in the Eyes of Rats, Hamsters, Gerbils and Guinea Pigs

Johansson¹

1987

Cells Tissues Organs

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The scleral lamina cribrosa in the eyes of adult rats, hamsters, gerbils and guinea pigs was examined by ordinary histology and by scanning electron microscopy after soft tissue digestion. The complexity of the lamina, when mounted for scanning electron microscopy, was graded on a scale of 0 to 4.5 by three independent observers under × 60 magnification in a stereo microscope. The observers were unaware of the species and were offered the 44 specimens twice in random order. The average variance attributable to an observer was 22 ± 3% (SE) of the total variance of the gradings. The rat eyes had the least developed lamina cribrosa, with only 1–2 layers of sparse connective tissue. The mean complexity grading of 12 rat eyes was 1.6 ± 0.15. The lamina cribrosa of the eyes of gerbils and guinea pigs was much more developed with at least 3 layers of abundant connective tissue, the mean grades of complexity being 3.4 ± 0.09 and 3.5 ± 0.15, respectively, in 12 eyes of each species. The lamina cribrosa in the hamster eyes was somewhat more developed than that of the rat, but much less than that of the gerbil and guinea pig. The mean grade of complexity was 2.4 ± 0.14 in 8 eyes. In 6 pairs of rat eyes there was no correlation in grade of laminar complexity between the two eyes of the same animal. The present study makes the rat eye a candidate for experiments where a possible influence of the lamina cribrosa as such is undesired.

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Comparison of the Lamina Cribrosa in Mammalian Species With Good and With Indifferent Vision

Cited by 41 publications

References 3 publications

The human optic nerve: fascicular organisation and connective tissue types along the extra-fascicular matrix

The human optic nerve: fascicular organisation and connective tissue types along the extra-fascicular matrix

Capillaries of Rat Optic Nerve

The Lamina cribrosa in the Eyes of Rats, Hamsters, Gerbils and Guinea Pigs

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