Comparison of the ‘Iron Absorption Test’ with the Determination of the Iron‐Binding Capacity of Serum in the Diagnosis of Iron Deficiency*

Verloop, M. C.; Meeuwissen, Joris; Blokhuis, E. W. M.

doi:10.1111/j.1365-2141.1958.tb03835.x

Cited by 28 publications

(6 citation statements)

References 18 publications

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“…The increase in serum iron expressed as a ratio of the final to the initial concentration was taken as an indicator of iron absorption. 19 Bone marrow was aspirated after sternal puncture in the anaemic patients. Iron content was measured by Perls' Prussian blue.…”

Section: Laboratory Proceduresmentioning

confidence: 99%

Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness.

Vreugdenhil

Wognum

Eijk

et al. 1990

Annals of the Rheumatic Diseases

111

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Section: Laboratory Proceduresmentioning

confidence: 99%

Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness.

Vreugdenhil

Wognum

Eijk

et al. 1990

Annals of the Rheumatic Diseases

111

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“…The oral iron absorption test (OIAT) was devised some 60 years ago [5][6][7][8][9]. In the first attempt to examine iron absorption, a stable iron radioisotope was used.…”

Section: Introductionmentioning

confidence: 99%

Establishment of a simple test for iron absorption from the gastrointestinal tract

et al. 2011

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Recent studies on iron metabolism have begun to reveal the molecular mechanisms underlying iron absorption, which is dramatically affected in several disorders. In the clinical setting, the ability to determine the status of iron absorption would aid in the diagnosis of pathological conditions. Efforts to develop an oral iron absorption test (OIAT) date back to at least 60 years. However, previous procedures were associated with a number of problems, such as radiation exposure and low reproducibility. In an attempt to resolve these issues, we employed sodium ferrous citrate (SFC), by which the influence of various nutrients and drugs on iron absorption was markedly reduced. We found that OIAT using SFC was simple to perform in both hospitalized patients and outpatients. The increment of serum iron and % transferrin saturation at 120 min after SFC administration was useful in distinguishing iron absorption between healthy volunteers, patients with iron-deficiency anemia, and patients with anemia secondary to chronic disorders, which are respectively characterized by normal, enhanced, and reduced iron absorption. Thus, the SFC-based OIAT may represent a viable screening test for the evaluation of gastrointestinal iron absorption.

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“…The oral iron absorption test (OIAT) was introduced more than 30 yr ago to study iron absorption in patients with iron deficiency. Despite the simplicity and safety of the OIAT, this technique has never become popular because of its lack of sensitivity (1)(2)(3). Later, smaller doses were administered and a good correlation between the absorption of iron from different oral doses compared to the more complicated radioisotope technique of whole body counting was demonstrated (4).…”

mentioning

confidence: 99%

Small‐dose oral iron absorption test in anaemic and non‐anaemic elderly hospitalized patients

Joosten

Elst²,

Billen

1997

European J of Haematology

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The small‐dose (20 mg) oral iron absorption test (OIAT) was performed in 76 hospitalized elderly patients and 30 healthy adults. Of the elderly patients, 34 were considered as iron deficient (serum ferritin level <20 μg/L) of whom 23 were anaemic and 11 not anaemic, 21 had the anaemia of chronic disorders (ACD) and another 21 were non‐anaemic patients with a normal serum ferritin level. There was a significant inverse correlation between the serum ferritin level as a measure of iron store and the maximum increase in serum iron during a 3‐h test (Cmax), in the elderly as well as in the healthy adult group. A decision limit of 80 μg/dL for Cmax is a good discriminant between absent (serum ferritin <20 μg/L) and adequate body iron stores. Sixty‐eight per cent of the patients with a serum ferritin level <20 μg/L but virtually none of the ACD patients, non‐anaemic elderly inpatients with normal serum ferritin levels and healthy adults had a Cmax level >80 μg/L. Although further investigation is needed before the OIAT can be recommended as a valuable test for evaluating iron absorption, predicting mild iron deficiency and differentiating between different categories of anaemia, it seems worthwile that more effort should be done to validate this simple and safe test.

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Comparison of the ‘Iron Absorption Test’ with the Determination of the Iron‐Binding Capacity of Serum in the Diagnosis of Iron Deficiency*

Cited by 28 publications

References 18 publications

Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness.

Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness.

Establishment of a simple test for iron absorption from the gastrointestinal tract

Small‐dose oral iron absorption test in anaemic and non‐anaemic elderly hospitalized patients

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