Comparison of the intraperitoneal and intravenous routes of cisplatin administration in an advanced ovarian cancer model of the rat

Sekiya, Souei; Iwasawa, H.; Takamizawa, H

doi:10.1016/0002-9378(85)90605-2

Cited by 13 publications

(4 citation statements)

References 6 publications

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“…It has been observed in rats that the cisplatin levels in intra-abdominal tumor tissues following the use of the intraperitoneal route are greater than those after the intravenous route. In addition, concentrations of cisplatin in serum are also sufficiently greater with prolonged drug elimination after the use of the intraperitoneal route [50]. In another study, cisplatin injected intraperitoneally, significantly prolonged the lifespan median by 88% and in fact, it was ineffective when injected intravenously, in experimental rats with disseminated ovarian cancer [51].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy

Shahid

Subhan

Ahmad

et al. 2019

BMC Pharmacol Toxicol

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Background Chemotherapy induced peripheral neuropathy (CIPN) has been attributed to chemotherapeutic agents such as cisplatin which adversely affect disease outcome leading to increased cancer related morbidity. The clinical efficacy of systemic gabapentin in neuropathic pain management is limited by central side-effects in addition to a scarceness of conclusive evidence of its efficacy in CIPN management. The topical route therefore may provide a relatively safe alternative for neuropathic pain treatment in general and CIPN in particular. Methods Cisplatin induced neuropathic nociception was established in rats after a single weekly cisplatin injection (3.0 mg/kg, intraperitoneally) for 4 weeks. The evoked neuropathic sensation of allodynia was assessed by plantar application of von Frey monofilaments as the paw withdrawal threshold (PWT), whereas the expression of heat-hypoalgesia was determined on a hot-plate as paw withdrawal latency (PWL). Gabapentin gel (10% w/w) was applied three-times daily on the hind paws while in a concurrent systemic study, gabapentin was administered daily (75 mg/kg, intraperitoneally) for 4 weeks. To assess any evidence of neurological adverse symptoms of cisplatin and the central side-effect propensity of systemic or topical gabapentin, evaluation of motor coordination (rotarod test) and gait (footprint analysis) were performed. Results Cisplatin invoked a progressive development of neuropathic hind paw allodynia (decreased PWT, days 7–28) and heat hypoalgesia (increased PWL, days 21–28). Topical gabapentin significantly delayed the expression of both allodynia on protocol days 21 and 28 and heat-hypoalgesia (day 28). Systemic gabapentin displayed a comparative anti-neuropathic predisposition through a sustained suppression of tactile allodynia on days 14 and 21–28 as well as thermal hypoalgesia (days 21 and 28). Systemic gabapentin also impaired motor coordination and gait thus affirming its clinically documented central side effects, but these outcomes were not evident after topical treatment. Conclusions Both topical and systemic gabapentin exhibit a propensity to attenuate CIPN in a cisplatin paradigm. Gabapentin applied topically may therefore provide an adjunctive or alternative route for CIPN management upon cessation of systemic medications due to intolerable side-effects. Electronic supplementary material The online version of this article (10.1186/s40360-019-0329-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy

Shahid

Subhan

Ahmad

et al. 2019

BMC Pharmacol Toxicol

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“…When lethal dose was used (16 mg/kg) cisplatin was found also in renal columns (observation time: day 3), while in the medulla (location of the loop of Henley and collecting tubule) the levels of cisplatin were the lowest, regardless of the dose [ 36 ]. In addition, it was found that the intraperitoneal application of cisplatin has a reservoir effect, which prolongs the serum half-life of cisplatin in comparison to the intravenous route [ 37 ].…”

Section: Cisplatin Nephrotoxicity In Rodentsmentioning

confidence: 99%

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Perše

Večerić-Haler

2018

BioMed Research International

170

140

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Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney injury, which involves both local events in the kidney and interconnected and interdependent systemic effects in the body, cisplatin rodent model is indispensable in the investigation of underlying mechanisms and potential treatment strategies of both acute and chronic kidney injury. Cisplatin rodent model is well appreciated and widely used model due to its simplicity. It has many similarities to human cisplatin nephrotoxicity, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using cisplatin model. The present paper is aimed at giving a concise insight into the complex characteristics of cisplatin rodent model and heterogeneity of cisplatin dosage regimens as well as outlining factors that can severely influence the outcome of the model and the study. Challenges for future research are also mentioned.

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“…However, when a lethal dose was used (16 mg/kg BW) cisplatin was detected in renal columns (on day 3). 24,25 Moreover, cisplatin at a dose of 20 mg/kg BW can inhibit fatty acid oxidation in animal models. 6 In this study, neither dose of ASEE altered the total cholesterol levels of cisplatininduced male Wistar rats.…”

Section: The Effect Of Asee On Total Cholesterol Levels Of Wistar Ratsmentioning

confidence: 99%

The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats

Wahyuni,

Aulifa,

Rosdianto

et al. 2024

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Cisplatin is a platinum-based anticancer drug that, in long-term use, causes nephrotoxicity due to oxidative stress and increases total cholesterol and triglycerides in animal models. Angelica keiskei (Miq.) Koidz., (A. keiskei) or Japanese celery ashitaba, has been reported for its antioxidant and nephroprotective activity. This study aims to determine the activity of A. keiskei sap on total cholesterol levels of cisplatin-induced Wistar rats. The sap of A. keiskeiwas freeze-dried until a yield of 3.62% w/v was obtained. The fat content in A. keiskei sap powder was obtained at 7.36%. A total of 60 g of A. keiskei sap powder was macerated with 96% ethanol solvent (1:10) for 5 x 24 h until the ethanol extract of A. keiskei sap (ASEE) of 82.08% w/w was obtained. The pharmacology activity was conducted on male Wistar rats, which were divided into 5 groups, namely normal (treated with CMC Na 0.3%), negative (nephrotoxicity induced with cisplatin 5 mg/kg BW), positive (nephrotoxicity induced with cisplatin 5 mg/kg BW and treated with quercetin 20 mg/kg BW), and two test groups which were nephrotoxicity induced with cisplatin 5 mg/kg body weight and treated with ASEE 1000 mg/kg BW, and ASEE 1500 mg/ kg BW. It was found that neither dose of ASEE altered the total cholesterol levels in cisplatin-induced male Wistar rats and could maintain the cholesterol levels in the normal range.

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Comparison of the intraperitoneal and intravenous routes of cisplatin administration in an advanced ovarian cancer model of the rat

Cited by 13 publications

References 6 publications

Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy

Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats

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