Comparison of the Insulin Reaction of Peripheral Blood T Cells between Healthy Holstein Dairy Cows and JB during the Periparturient Period

Ohtsuka, Hiromichi; Kitagawa, Madoka; Kohiruimaki, Masayuki; Tanami, Erika; Masui, Machiko; Hayashi, Tomohito; Ando, Takaaki; Watanabe, Daisaku; Koiwa, Masateru; Satō, Shigeru; Kawamura, Seiichi

doi:10.1292/jvms.68.1211

Cited by 7 publications

(4 citation statements)

References 16 publications

(18 reference statements)

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“…The lower GH-R expression of the Weight Loss Group during month 2 might have been due to depression of lymphocyte response stimulated by PHA. Previous report have found that periparturie n t H o l s t e i n c o w s f r e q u e n t l y e x p e r i e n c e immunosuppression following reduction of glucose transport activity in T cells [18]. We doubtful that GH played a role in the immune system of the periparturient dairy cows preventing the occurrence of infectious disease.…”

Section: Cd45rmentioning

confidence: 85%

Changes in Peripheral Blood Mononuclear Cells after Calving in Lactating Cows with Serious Decrease of Body Weight before and after Calving

Ohtsuka

Kase

Ando

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. The aim of this study was to clarify the hormonal and immunological changes in periparturient dairy cows with excessive weight loss following calving. We analyzed leukocyte populations and the peripheral blood mononuclear cell (PBMC) mRNA of IFN-γ, IL-4, growth hormone (GH)-receptor (R) and insulin -R and measured the GH and insulin concentrations. Ten dairy cows fed in one herd were used in this study and were divided into two groups. Five cows that experienced loss of body weight following calving of over 10% comprised the Weight Loss Group, and the remaining five cows, which experienced loss of body weight of 5% or less fol-

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Section: Cd45rmentioning

confidence: 85%

Changes in Peripheral Blood Mononuclear Cells after Calving in Lactating Cows with Serious Decrease of Body Weight before and after Calving

Ohtsuka

Kase

Ando

et al. 2008

The Journal of Veterinary Medical Science

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“…The available disease-associated variables, mastitis, SCC above 100,000, retained placenta, metritis, and ketotic risk were used to exclude diseased cows, as these are known in uencing factors on milk yield (42,43). Parity, another known in uencing variable on milk yield and the periparturient cow's immune system (29,44,45) proved to be signi cant in univariable analysis of the present study. Thus, parity was reduced to primiparous cows.…”

Section: Statistical Analysesmentioning

confidence: 89%

Prepartal vaccination has no influence on mammary health and milk yield of dairy cows: a retrospective study addressing non-specific effects of vaccination

Kuhn,

Zerbe,

Schuberth

et al. 2024

Preprint

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Background: Prepartal vaccinations against newborn calf diarrhea pathogens are performed in the last weeks of pregnancy, with the intention to induce a maternal adaptive humoral immune response and to protect calves in the first weeks of life via colostral transferred pathogen-specific antibodies. There is evidence that vaccination-related innate immune responses can also affect the mother's immune system response to stressors. Whether such non-specific vaccine effects alter the disease susceptibility of dairy cows in the very sensitive transition period has not been addressed so far. In a retrospective cross-sectional study, we investigated the influence of prepartal maternal vaccination on mammary health and milk yield of the periparturient dairy cow. Herd record data from 73,378 dairy cows from 20 farms located in Eastern Germany, together with on-site-collected survey data, were analyzed using linear mixed-effects regression, quantile regression and random forest machine-learning algorithms. A total of 57,166 transition periods without prior vaccination, distributed along 16 herds, and 63,228 transition periods on 13 herds with prior vaccination are included. Additionally healthy primiparous cows from alternately vaccinated herds were analyzed. Results: Herd management-related factors, such as herd in general and calving year, as well as parity proved to be most influential for mammary health and milk yield, while prepartal vaccination occurred as least influential. Vaccinated cows did not show significant differences in mastitis prevalence and somatic cell count as compared with non-vaccinated cows. Also, energy corrected milk yield on first test day of milk recordings, as well as in 305-days of lactation, of healthy primiparous cows with and without prior vaccination showed no significant differences. Conclusions: This study presents evidence that prepartal vaccination against newborn calf diarrhea does not have significant non-specific effects on mammary health and milk yield parameters. Instead, the findings highlight the importance of herd management factors. This work emphasizes the significance of multivariable analysis based on a large database with high statistical power. It also recommends further research to explore potential non-specific vaccination effects on other organ systems, infectious diseases, and production metrics in cows.

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“…The leukocyte fraction consists mainly of lymphocytes, macrophages, and neutrophils, and its concentration depends on diet, age, breed, and physiological and individual conditions [8,373,374]. For example, it has been shown that heifers have lower activity of colostral immune cells than cows with three or more lactations [375]. On the other hand, Kampen et al [376] found no significant effect of cow health status on colostral lymphocyte concentration.…”

Section: Cellsmentioning

confidence: 99%

A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology

Silva,

Pereira

et al. 2024

Animals

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Colostrum contains macro- and micronutrients necessary to meet the nutritional and energy requirements of the neonatal calf, bioactive components that intervene in several physiological aspects, and cells and microorganisms that modulate the calf’s immune system and gut microbiome. Colostrum is sometimes mistaken as transition milk, which, although more nutritive than whole milk, has a distinct biochemical composition. Furthermore, most research about colostrum quality and colostrum management focuses on the transfer of maternal IgG to the newborn calf. The remaining components of colostrum and transition milk have not received the same attention, despite their importance to the newborn animal. In this narrative review, a large body of literature on the components of bovine colostrum was reviewed. The variability of these components was summarized, emphasizing specific components that warrant deeper exploration. In addition, the effects of each component present in colostrum and transition milk on several key physiological aspects of the newborn calf are discussed.

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Comparison of the Insulin Reaction of Peripheral Blood T Cells between Healthy Holstein Dairy Cows and JB during the Periparturient Period

Cited by 7 publications

References 16 publications

Changes in Peripheral Blood Mononuclear Cells after Calving in Lactating Cows with Serious Decrease of Body Weight before and after Calving

Changes in Peripheral Blood Mononuclear Cells after Calving in Lactating Cows with Serious Decrease of Body Weight before and after Calving

Prepartal vaccination has no influence on mammary health and milk yield of dairy cows: a retrospective study addressing non-specific effects of vaccination

A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology

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