Comparison of the influence of two different constant-rate infusions (dexmedetomidine versus morphine) on anaesthetic requirements, cardiopulmonary function and recovery quality in isoflurane anaesthetized horses

Gozalo-Marcilla, Miguel; Steblaj, Barbara; Schauvliege, Stijn; Duchateau, Luc; Gasthuys, Frank

doi:10.1016/j.rvsc.2013.09.014

Cited by 35 publications

(46 citation statements)

References 31 publications

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“…Dexmedetomidine induces antinociception in conscious dogs, cats, rats and human beings (Sabbe et al, 1994;Slingsby et al, 2009;Aydogan et al, 2013;Kosharskyy et al, 2013) and reduces the requirements for inspired anaesthetic gas in dogs (Pascoe et al, 2006;Uilenreef et al, 2008), cats (de Souza et al, 2010 and horses (Gozalo-Marcilla et al, 2013a, 2013b, 2013c. In the present study, we determined the antinociceptive effects of dexmedetomidine infusions in conscious horses.…”

Section: Discussionmentioning

confidence: 85%

“…α-2 Agonists are used as constant rate infusions (CRI) during anaesthesia to provide antinociception and to reduce the requirement for inhaled anaesthetic agents in horses (Bettschart-Wolfensberger et al, 2001Gozalo-Marcilla et al, 2013a, 2013b, 2013c. Antinociception with dexmedetomidine is mediated primarily through α-2a receptors in the spinal cord (Yaksh, 1985;Takano and Yaksh, 1991;Guo et al, 1996;Zhao et al, 2013), but an effect within the locus coeruleus also produces antinociception (Guo et al, 1996;Funai et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Risberg

Spadavecchia

Ranheim

et al. 2014

The Veterinary Journal

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Risberg

Spadavecchia

Ranheim

et al. 2014

The Veterinary Journal

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“…The a2-adrenoreceptor agonist dexmedetomidine is commonly used in small animal anaesthesia and is gaining popularity in equine anaesthesia . The majority of horses undergoing general anaesthesia are sedated with an a2-agonist prior to anaesthesia induction and balanced anaesthesia including a2-agonists is gaining widespread popularity (Kalchofner et al 2006, Ringer et al 2007, Gozalo-Marcilla et al 2013. The main cardiovascular effect of a2-adrenoreceptor agonists is vasoconstriction, which may alter the accuracy of blood pressure monitoring devices.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of accuracy of invasive and non-invasive blood pressure monitoring in relation to carotid artery pressure in anaesthetised ponies

Gent¹,

Schwarz²,

Hatz³

et al. 2015

PHK

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Summary: Invasive blood pressure measurement (IBP) using peripheral arteries is a commonly used technique in equine anaesthesia, although the accuracy has not been demonstrated. Non-invasive blood pressure monitoring (NIBP) may be indicated for field anaesthesia, short procedures and foal anaesthesia. In the present report, the agreement of various IBP and NIBP measuring sites compared to carotid artery pressure was tested in anaesthetised experimental ponies. Six ponies were anaesthetised in lateral recumbency with sevoflurane and received either saline or dexmedetomidine boli followed by constant rate infusion (CRI). Invasive blood pressure measurements were obtained simultaneously from the carotid, facial and metatarsal arteries. NIBP measurements over both median arteries, metatarsal and middle coccygeal arteries were performed in random order. All blood pressure readings obtained were compared to carotid pressure by BlandAltman analysis. Non-invasive blood pressure measurements had larger bias and poorer limits of agreement compared to IBP measurements. NIBP measurement from the coccygeal artery had the best repeatability and best limits of agreement of all NIBP positions and was not affected by the use of dexmedetomidine. The facial artery had smaller limits of agreement with dexmedetomidine treatment. There was no difference between the facial and metatarsal arteries during dexmedetomidine treatment in MAP and DAP. Systolic arterial pressures from the metatarsal artery showed larger bias and larger limits of agreement compared to facial artery. In conclusion, NIBP measurement from the tail artery is a reliable alternative to direct arterial blood pressure measurement. Both the metatarsal and facial arteries have acceptable agreement with carotid artery pressure so the choice can be based on the logistics of the procedure.Keywords: Anaesthesia / Dexmedetomidine / Equine / Blood Pressure / Monitoring Vergleich der Genauigkeit einer invasiven und nicht-invasiven peripheren Blutdruckmessung zum Karotisdruck bei anästhe-sierten PoniesIn vielen Pferdekliniken gehört die invasive Messung des arteriellen Blutdruckes (IBP) mittels Katheter in peripheren Arterien während einer Pferdeanästhesie zur Standardüberwachung der Anästhesie, obwohl die Genauigkeit dieser Messung nie belegt wurde. Nichtinvasive Blutdruckmessung ist eine mögliche Alternative für Feldanästhesien, kurze Eingriffe oder bei Fohlen. In der voliegenden Studie wurde die Über-einstimmung von an verschiedenen Stellen invasiv und nichtinvasiv gemessenen Blutdrücken mit dem Blutdruck in der Arteria Karotis bei unter experimentellen Bedingungen anästhesierten Ponis bestimmt. Sechs Ponis wurden in Seitenlage mit Sevofluranästhesie anästhesiert und erhielten zusätzlich Kochsalzlösung oder Dexmedetomidin Boli gefolgt von einer kontinuierlichen Infusion. Der invasive Blutdruck wurde gleichzeitig in der Arteria f., der A. metatarsalis und der A. karotis gemessen. Nicht invasive Blutdruckmessungen über der Schweifarterie, den beiden Medianarterien oder der Met...

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“…Da mesma forma, a fenilbutazona (inibidor não-seletivo da COX) tem mostrado relação com úlceras ou colite (MCCONNICO et al, 2008). O uso de opióides também tem sido relato como fator de risco para o desenvolvimento de cólica (SENIOR et al, 2004;GOZALO-MARCILLA et al, 2013). No entanto, Andersen et al (2006) encontraram que a administração de morfina em período perianestésico não foi associada ao aumento do risco de cólica; todavia, alegam a necessidade de um estudo multicêntrico colaborativo para garantir os achados deste estudo.…”

Section: Alguns Estudos Demonstraram Que Os Alfa-2 Agonistas Inibem Aunclassified

“…A morfina tem sido apontada como principal opióide causador de cólica por alguns autores (SENIOR et al, 2004;GOZALO-MARCILLA et al, 2013 Na janela do estômago avaliou-se tanto o espessura quanto a própria visualização dessa estrutura. Para esse último, o grupo 2 mostrou uma mudança significativa entre os dias D1 e D5.…”

Section: Comparação Entre Os Grupos No Momento D-entrada (Grupo 1) E unclassified

<b>Controle ultrassonográfico do sistema gastrointestinal de cavalos hospitalizados por queixas primárias de claudicação submetidos ou não a cirurgia ortopédica</b>

Martins¹

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AgradecimentosAo meu pai, que apesar de não ter tido oportunidade de me acompanhar nessa trajetória, sempre me apoiou em todas as minhas decisões e com quem sempre compartilhei meus sonhos. À minha mãe, responsável por muito do que sou e do que serei. A vocês, obrigada por todo amor e dedicação na minha formação. À minha irmã Isabelle, pelo suporte e apoio nos momentos de maior tensão.Ao Fefê, por todo amor, cumplicidade, ensinamento e parceria neste período.Obrigada por me passar um pouco de sua espiritualidade, por me ensinar a superar as dificuldades e mostrar que o no amor não existem diferenças. Agradeço também às nossas cachorrinhas Clara, Madona e Tina.À Elisinha, por todo amor e festa desde o momento que acordo até a minha volta para casa. Obrigada por me ensinar a amar mais os animais e ter ainda mais compaixão por eles. Group 2 comprised horses admitted to the hospital for medically managed orthopedic cases. Group 1 consisted of horses admitted to the hospital for surgical management under general anesthesia. Group 2 comprised horses admitted to the hospital for medically managed orthopedic cases. Group 1 consisted of horses admitted to the hospital for orthopedic surgery. Group 2 comprised horses admitted to the hospital for medically managed orthopedic cases. Abdominal ultrasonography was performed daily from admission to fifth day of hospitalization. Group 1 animals also had pre-and post-operative ultrasonographic evaluation to assess the effect of surgery on the gastrointestinal system. Ultrasonography was not successful at early detection of colic in any animal. The results also showed a higher incidence of colic in animals undergoing surgery (with no statistical difference), particularly on the second or third day postoperative, as well as a reduction in both large and small colon motility in animals undergoing surgery. No significant changes in wall thickness of the evaluated loops were observed. In conclusion, ultrasonographic examination could not successfully predict colic but was useful for confirmation of gastrointestinal originof clinical symptoms during the examination of affected animals.

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Comparison of the influence of two different constant-rate infusions (dexmedetomidine versus morphine) on anaesthetic requirements, cardiopulmonary function and recovery quality in isoflurane anaesthetized horses

Cited by 35 publications

References 31 publications

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Evaluation of accuracy of invasive and non-invasive blood pressure monitoring in relation to carotid artery pressure in anaesthetised ponies

<b>Controle ultrassonográfico do sistema gastrointestinal de cavalos hospitalizados por queixas primárias de claudicação submetidos ou não a cirurgia ortopédica</b>

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