Comparison of the Incidence of Vancomycin‐Induced Nephrotoxicity in Hospitalized Patients with and without Concomitant Piperacillin‐Tazobactam

Burgess, Lindsey D.; Drew, Richard H.

doi:10.1002/phar.1442

Cited by 182 publications

(212 citation statements)

References 12 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…Burgess & Drew (2014) The present study has several limitations that must be discussed in combination with the results. The time frames for inclusion could have encompassed a larger date range with the same number of months included in the pre-implementation and post-implementation groups to account for seasonal variations in antibiotic-prescribing patterns.…”

Section: Discussionmentioning

confidence: 83%

Effect of piperacillin/tazobactam restriction on usage and rates of acute renal failure

Lorenz

Moenster

Linneman

2016

Journal of Medical Microbiology

View full text Add to dashboard Cite

A piperacillin/tazobactam (PT) restriction was initiated at our institution on 15 July 2012 requiring clinical pharmacy or infectious diseases approval for durations exceeding 72 h. A retrospective review was undertaken to determine whether this restriction decreased PT usage and/or rates of acute renal failure (ARF) (defined as a 50 % increase or 0.5 mg dl 21 increase in serum creatinine from baseline). Patients prescribed at least 1 day of PT with a creatinine clearance of $39 ml min 21 at the time of initiation in the 3 months prior to the restriction were compared with patients in the 5 months after restriction implementation. Overall, 115 unique patients were included in the pre-implementation group and compared with 117 unique patients in the post-implementation group. The pre-implementation group received a mean of 5.22 days of PT, compared with 4.71 days in the post-implementation group (P50.224). Ten per cent (12/115) of patients in the pre-implementation group developed ARF compared with 9.17 % (11/120) of patients in the post-implementation group (P50.0309). Ninety-five patients in the pre-implementation group and 91 in the post-implementation group received combination therapy with vancomycin. ARF occurred in 11.6 % (11/95) of those in the pre-implementation group and 12.1 % (11/91) in the post-implementation (P.0.05). Overall, 11.8 % (22/186) of patients who received therapy with PT and vancomycin developed ARF, compared with 1.7 % (1/56) who received PT monotherapy (P,0.0001). This restriction resulted in a numeric reduction in the number of PT days in the post-implementation group and a significant reduction in the rate of ARF.

show abstract

Section: Discussionmentioning

confidence: 83%

Effect of piperacillin/tazobactam restriction on usage and rates of acute renal failure

Lorenz

Moenster

Linneman

2016

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Empiric antibiotic therapy often involves combinational agents which further increase risk of nephrotoxicity. 59,60 Furthermore, among patients with heart failure which commonly complicates IE, the risk of nephrotoxicity is heightened. 61 …”

Section: Little Capacity For Therapeutic Drug Monitoringmentioning

confidence: 99%

Infective Endocarditis in Low- and Middle-Income Countries

et al. 2017

View full text Add to dashboard Cite

Key Points Staphylococcus is an increasingly important cause of IE in LMICs, and is the leading cause of IE in UMICs  RHD remains the major underlying cardiac pathology of IE in LMICs, identified in almost half of reported cases  The rate of microorganism non-identification is high, reaching up to 60% of IE cases in LMICs, and hampering diagnosis and treatment  Rates of access to surgery in UMICs for complicated IE are as high as in HICs, but remain dismal in lower-middle income countries SynopsisInfective endocarditis (IE) is a rare, life-threatening disease with a mortality rate of upto 25% and significant debilitating morbidities. Although much has been reported on contemporary IE in high income countries, conclusions on the state of IE in low and middle income countries (LMICs) are based on studies conducted before the year 2000. Furthermore, unique challenges in the diagnosis and management of IE persist in LMICs. This article is a review of IE studies conducted in LMICs documenting clinical experiences from the year 2000 to present. We present the causes of IE, management of patients with IE and the prevailing challenges in diagnosis and treatment of IE in LMICs.

show abstract

“…45 This finding with piperacillin-tazobactam is not surprising as its nephrotoxicity risk appears to be more significant than previously appreciated. [46][47][48][49] We do not believe that the tobramycin was the cause of the AKI alone in our case, but rather a contributing factor. Our patient experienced significant post-operative hypotension for a brief time period and was also on intravenous vancomycin.…”

Section: 32-35mentioning

confidence: 74%

Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature

James

Larson

2015

Renal Failure

View full text Add to dashboard Cite

High-dose antibiotic-loaded bone cement (ALBC) spacers are commonly used to treat prosthetic joint infections following total hip and knee arthroplasties. This methodology can provide high local antibiotic concentrations while minimizing systemic exposure and toxicity. The occurrence of acute kidney injury (AKI) is rarely reported. Available literature suggests that the rate may be higher than previously thought. We report a case of significant systemic tobramycin absorption with concomitant acute renal failure in a 69-year-old female following the implantation of a high-dose ALBC spacer containing both tobramycin and vancomycin. The tobramycin level 24 h post-surgery was 5.8 mcg/mL. Due to concomitant renal failure, antibiotic clearance was poor and resulted in prolonged exposure to elevated aminoglycoside levels. Recovery of renal function occurred, but clinicians should be vigilant in considering the potential impact ALBC spacers can have on post-operative renal function if antibiotic elution is higher than expected.

show abstract

Comparison of the Incidence of Vancomycin‐Induced Nephrotoxicity in Hospitalized Patients with and without Concomitant Piperacillin‐Tazobactam

Cited by 182 publications

References 12 publications

Effect of piperacillin/tazobactam restriction on usage and rates of acute renal failure

Effect of piperacillin/tazobactam restriction on usage and rates of acute renal failure

Infective Endocarditis in Low- and Middle-Income Countries

Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature

Contact Info

Product

Resources

About