Comparison of the <i>in vitro</i> toxicological activity of various particulate matter

Cho, Hyun-Ki; Park, Chang-Gyun; Shin, Han-Jae; Park, Kihong; Lim, Hyun

doi:10.1177/0748233717749694

Cited by 21 publications

(4 citation statements)

References 45 publications

(61 reference statements)

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“…Reactive oxygen species (ROS) formation is a cellular response seen in various combustion emission exposure studies [25,29,62,63]. In this study, intracellular ROS formation was not detected by the 2′,7′-dichlorodihydrofluorescein diacetate (H 2 DCFDA) assay in Tox-ALIexposed cells (Supplementary Materials and Supplementary Fig.…”

Section: Oxidative Stressmentioning

confidence: 83%

Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke

et al. 2020

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Background: Wood combustion emissions have been studied previously either by in vitro or in vivo models using collected particles, yet most studies have neglected gaseous compounds. Furthermore, a more accurate and holistic view of the toxicity of aerosols can be gained with parallel in vitro and in vivo studies using direct exposure methods. Moreover, modern exposure techniques such as air-liquid interface (ALI) exposures enable better assessment of the toxicity of the applied aerosols than, for example, the previous state-of-the-art submerged cell exposure techniques. Methods: We used three different ALI exposure systems in parallel to study the toxicological effects of spruce and pine combustion emissions in human alveolar epithelial (A549) and murine macrophage (RAW264.7) cell lines. A wholebody mouse inhalation system was also used to expose C57BL/6 J mice to aerosol emissions. Moreover, gaseous and particulate fractions were studied separately in one of the cell exposure systems. After exposure, the cells and animals were measured for various parameters of cytotoxicity, inflammation, genotoxicity, transcriptome and proteome.

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Section: Oxidative Stressmentioning

confidence: 83%

Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke

et al. 2020

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“…Additionally, they alter vascular transcription and represent the highest mutagenic activity. Generation of ROS is crucial and can in uences both -long-and shortterm effects of air pollutants on renal function [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Exposure to air pollution and renal function - an underestimated threat?

Kuźma

Małyszko

Kurasz

et al. 2021

European Journal of Preventive Cardiology

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Funding Acknowledgements Type of funding sources: None. Introduction Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year. The adverse effects of air pollution can be observed not only in respiratory, circulatory, and nervous systems but also in renal function. Purpose Our goal was to investigate the hypothesis indicating that we can observe the long-term and also short-term impact of air pollution on kidney function. Methods We reviewed medical notes of patients hospitalized between 2007-2016. We used linear, log-linear, and logistic regression models to assess the association between renal function and NO2, SO2, and PMs. Results are reported as beta (β) coefficients and odds ratios (OR) for an increase in interquartile range (IQR) concentration with 95% confidence intervals (CI). Results 3,554 patients were included into the final analysis. The median age was 66 (IQR 15) and men were in the majority (53.2%, N = 1891). Chronic kidney disease (CKD) was diagnosed in 21.5% (N = 764). The long-term increase in annual average concentration of PM2.5 (OR for IQR increase = 1.07; 95% CI 1.01 – 1.15, P = 0.037) and NO2 (OR for IQR increase = 1.05;95% CI 1.01 – 1.10, P = 0.047) resulted in an increased number of patients with CKD. In short-term observation the IQR increase in weekly PM2.5 concentration was associated with a 2% reduction in eGFR (OR = 0.98, 95%CI 0.97 – 0.99, P = 0.03) Conclusions The effects of air pollution on renal function were observed. Long- and short–term exposure to elevated air pollution levels was associated with a decrease in eGFR. The main pollutant affecting the kidneys was PM2.5.

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“…The origin of air pollutants has an impact on the chemicals that are bound on the surface of particulate matter [17,18]. When comparing the health effects of various PM 2.5 sources, diesel exhaust particles (DEPs) represent the highest mutagenic activity, generate the most intracellular reactive oxygen species (ROS), and cause altered vascular transcription [19][20][21]. Generation of ROS is crucial and influences both long-and short-term effects of air pollutants.…”

Section: Discussionmentioning

confidence: 99%

The 10-Year Study of the Impact of Particulate Matters on Mortality in Two Transit Cities in North-Eastern Poland (PL-PARTICLES)

Kuźma

Dąbrowski

Kurasz

et al. 2020

JCM

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The detrimental influence of air pollution on mortality has been established in a series of studies. The majority of them were conducted in large, highly polluted cities—there is a lack of studies from small, relatively clean regions. The aim was to analyze the short-term impact of particulate matters (PMs) on mortality in north-eastern Poland. Time-stratified case-crossover design was performed for mortality in years 2008–2017. Daily concentrations of PM2.5 (28.4 µg/m3, interquartile range (IQR) = 25.2) vs. (12.6 µg/m3, IQR = 9.0) and PM10 (29.0 µg/m3, IQR = 18.0) vs. (21.7 µg/m3, IQR = 14.5) were higher in Łomża than Suwałki (p < 0.001). Impact of PM2.5 on mortality was recorded in Łomża (odds ratio (OR) for IQR increase 1.061, 1.017–1.105, p = 0.06, lag 0) and Suwałki (OR for IQR increase 1.044, 1.001–1.089, p = 0.004, lag 0). PM10 had an impact on mortality in Łomża (OR for IQR increase 1.028, 1.000–1.058, p = 0.049, lag 1). Cardiovascular mortality was affected by increase of PM2.5 in Łomża (1.086, 1.020–1.156, p = 0.01) and Suwałki (1.085, 1.005–1.171, p = 0.04). PM2.5 had an influence on respiratory mortality in Łomża (1.163, 1.021–1.380, p = 0.03, lag 1). In the whole studied region, despite differences in the air quality, the influence of PMs on mortality was observed.

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Comparison of the in vitro toxicological activity of various particulate matter

Cited by 21 publications

References 45 publications

Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke

Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke

Exposure to air pollution and renal function - an underestimated threat?

The 10-Year Study of the Impact of Particulate Matters on Mortality in Two Transit Cities in North-Eastern Poland (PL-PARTICLES)

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