Comparison of the hypolipidemic activity of cyclic vs. acyclic imides

Abstract

Two series of nitrogen-substituted cyclic and acyclic imides were examined for hypolipidemic activity in mice after dosing for 16 days at a dose of 20 mg/kg per day. The hypolipidemic activity of the unsubstituted, N-butyl, N-3-oxobutyl, and N-2-carboxyethyl derivatives of diacetimide and succinimide were compared as well as the unsubstituted and N-substituted dibenzimide and diphenimide. It was shown that an imide functionality incorporated into a ring was not necessary for hypocholesterolemic activity. Good hypocholesterolemic activity was observed in both series of acyclic and cyclic imides. However, a cyclic imido structure was a necessary requirement for good hypotriglyceridemic activity. A decrease in hypotriglyceridemic activity was noted when comparing the cyclic imides to their respective acyclic congeners.

Reactivity of 6-Hexanelactam Cyclic Oligomers, 1. Acidolysis

“…Simultaneously, in the chromatogram, a peak appeared, for the assignment of which we failed to find the corresponding standard. Hypothetically, by analogy with the reported 3-diacetylaminopropionic acid, [11] this substance could be N,N-diacetyl-6-aminohexanoic acid. We failed, however, to synthesize the latter compound.…”

“…and Equation (8), (9), (11 and Equation (8), (9), (11). The values of the rate constants were obtained by solving these equations by the Runge-Kutta fourth-order numerical integration combined with Nelder's simplex method.…”

Synthesis and characterization of novel organic heteroatom compounds from reaction of Woollins' reagent with various organic substrates

“…Treatment of Woollins' reagent with an equi-molar amount of N-benzoylbenzamide (1) 22 in refluxing toluene solution led to the formation of benzoic diselenoperoxyanhydride (2) in 53% isolated yield. Alternatively, applying Woollins' reagent with an equivalent of benzoic anhydride under identical conditions gave the same product (2) in 72% isolated yield (Scheme 1).…”

Microwave-Assisted Synthesis of Acyclic Imides

“…1 H NMR (400 MHz, CDCl3) δ (ppm): 2.61 (s, 3H); 7.17-7.21 (m, 2H); 7.88-7.90 (m, 2H); 8.63 (brs, 1H). N-Acetyl-3-nitrobenzamide (7): Yellow solid, Voorstad et al, 1985). FTIR (ATR) ν, cm -1 ; 3071, 1678, 1601.…”