Comparison of the Homology Between Muskrat Scented Gland and Mouse Preputial Gland

Han, Xiangyu; Jiang, Yuanlin; Feng, Nuannuan; Yang, P. J.; Zhang, Meishan; Jin, Weijiang; Zhang, Tianxiang; Huang, Zhixin; Zhao, Haoxi; Zhang, Kexin; Liu, Shuqiang; Hu, Defu

doi:10.1007/s10914-022-09604-w

Cited by 1 publication

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“…In mammals, fatty acids can be produced and released from other common tissue of mammals such as sweat gland, vagina, tear gland and fur in addition to mammary gland and milk, which may communicate the presence of mother or of other members of the same species [12][13][14][15][16][17] . In some mammalian species, fatty acids are also present and released in urine and specialized scent glands with the identified pheromones in rats, golden hamsters, musk rats, etc [18][19][20] . However, few fatty acids were detected in the urine and preputial glands in mice, and if fatty acids function as appeasing pheromones in mice, they are supposed to arise from the above-mentioned organs common to mammals, explaining why fatty acids are common appeasing pheromones in all mammals 2,21,22 .…”

Section: Introductionmentioning

confidence: 99%

The common fatty acids have a pheromone-like effect, improving the emotion in mice

Zhang

et al. 2022

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Fatty acids widely exist in some exocrine organs such as mammary glands, sweat glands and vaginas of mammals and have been exemplified to be appeasing pheromones in mammals. Here, we tested the possibility that fatty acids are common pheromones in mammals using mice that had few fatty acids in the main pheromone sources (eg.urine and preputial glands) of known pheromones. Five synthetic fatty acids were equally mixed to form a blend (MA) to be tested and a blend (MP) of hexadecanol and hexadecanol acetate of two identified male pheromones of mice was used as a control. Both MA and MP activated typical brain regions to perceive pheromones via. immunohistochemical staining. The numbers of c-Fos+ neurons activated by MA vs. MP were greater in the AOB and BNST, equal in VMH and smaller in the BLA. Chronic exposure to either MA or MP significantly reduced isolation-induced anxiety and improved sociality and exploring behavior. Especially, the mRNA expression of some behavior-related genes such as BDNF, GluN2B, DRD2, ERβ and 5HT2A was increased or showed a tendency to increase in hippocampus or mPFC of the mice after chronic exposure to either MA or MP. Our results suggested that some fatty acids might be common pheromones probably from the exocrine organs found in all mammals.

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Section: Introductionmentioning

confidence: 99%

The common fatty acids have a pheromone-like effect, improving the emotion in mice

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Comparison of the Homology Between Muskrat Scented Gland and Mouse Preputial Gland

Cited by 1 publication

References 53 publications

The common fatty acids have a pheromone-like effect, improving the emotion in mice

The common fatty acids have a pheromone-like effect, improving the emotion in mice

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