Comparison of the gold standard of hemoglobin measurement with the clinical standard (BGA) and noninvasive hemoglobin measurement (SpHb) in small children: a prospective diagnostic observational study

Abstract

Noninvasive measurement of hemoglobin agrees more with the reference method than the measurement of hemoglobin using a blood gas analyzer. However, both methods can show clinically relevant differences from the reference method (ClinicalTrials.gov: NCT01693016).

Assessment of haemoglobin measurement by several methods – blood gas analyser, capillary and venous HemoCue®, non‐invasive spectrophotometry and laboratory assay – in term and preterm infants

“…The variations in the displayed SpHb values during the evaluation time were high. Our within‐subject coefficient of variation in SpHb (6.1%) was higher than that previously reported in pre‐operative children and higher than the required standard for a Hb measurement device . Both a high rate of non‐displayed SpHb values and a high coefficient of variation indicate that SpHb measurements obtained using the Radical‐7 are not suitable as a spot‐check device in neonates.…”

“…During 26.1% of the monitoring time, SpHb was not displayed, which occurred distinctly more often than that reported in other studies measuring SpHb in adults and in pre‐operative children with a mean age of 3.3 years . The variations in the displayed SpHb values during the evaluation time were high.…”

Evaluation of the accuracy of a non-invasive hemoglobin-monitoring device in schoolchildren

“…The Radical-7 pulse CO-Oximeter was also used in another study that included 60 small children aged 0.2e7.6 years (mean age, 3.3 years), and a bias of 0.65 with a 95 % LOA ranging from À3.4 to 2.1 was found. 4 Furthermore, Ryan et al reported a low bias of À0.49, with the 95 % LOA ranging from À2.9 to 1.9, and a strong correlation of 0.67 between noninvasive measurements, obtained using a Pront pulse COoximeter (Masimo, Irvine, CA), and invasive assessments among 114 pediatric trauma patients (mean age, 9.2 AE 5.1 years). 5 In contrast to these previous studies, 4e6 our study shows a smaller bias with a more extensive 95 % LOA.…”

“…Furthermore, assessments were made in the operating room or the intensive care unit after prescribing general anesthesia. 4,6,7 Thus, little is known about the accuracy of non-invasive Hb monitoring in non-medical conditions among children and adolescents.…”

Enhancing Intelligent Anemia Detection via Unifying Global and Local Views of Conjunctiva Image with Two-Branch Neural Networks

“…In recent years, in order to improve the convenience of anemia examination, many studies have been carried out to investigate the effective approaches of detecting anemia in a noninvasive manner [4][5][6][7]. One of the most promising directions was to deploy artificial intelligent algorithms to discover the correlation of anemia with images of human surface organs, including fingernails, retinas, conjunctivas, etc.…”