Comparison of the Gastric Acid Responses to Pentagastrin and Insulin Hypoglycemia in Male and Female Ulcer Patients

Abstract

The 30-min peak acid output (PAO30) to pentagastrin and insulin hypoglycemia has been compared in male and female ulcer patients. In male duodenal ulcer, prepyloric gastric ulcer and corporal gastric ulcer patients the PAO30 to pentagastrin exceeded that to insulin; in female duodenal ulcer patients the PAO30 to pentagastrin tended to be higher than to insulin but the difference was not significant. The PAO30 to both pentagastrin and insulin was higher in male than in female duodenal ulcer patients but the ratio of PAO30 for insulin and pentagastrin did not differ significantly which suggests that the sex difference in the responses is similar for insulin and pentagastrin. The ratio tended to be lower in the male corporal gastric ulcer than in the male duodenal ulcer patients which might indicate that insulin hypoglycemia is relatively less effective than pentagastrin in stimulating acid secretion in corporal gastric ulcer than in duodenal ulcer patients.

Stimulation of Gastric Acid Secretion by Insulin and 2-Deoxy-D-Glucose in Duodenal Ulcer Patients

“…Insulin and 2 DG produced acid response in all 21 patients according to our criterion [4,5] and to the criteria of Hollander [10]. The results of the present study are in accordance with the findings of D uke et al [2]; the acid response to 2 DG appeared earlier than to insulin, and in 17 of 21 patients the response to 2 DG was higher than to insulin.…”

“…The age distribution was comparable in the two studies. Our results in the present and previous study [5] therefore suggest that the PAO 30 to 2 DG is close to or does not differ from the PAO 30 to pentagastrin in spite of the dose of 2 DG probably being submaximal and that of pentagastrin being maximal for acid secretion.…”

“…In a recent study [5], the PAO 30 to pentagastrin (6 pg/kg body weight s.c.) was 15.84 ±0.75 mEq and to insulin (0.2 U/kg i.v.) 12.97 ±0.68 mEq in male duodenal ulcer patients (median age 44 years).…”

“…The PAO 15 refers to the peak 15-niin acid output, and the PAO 30 to the 2 consecutive 15-min periods with the highest acid outputs after injection of the secretory stimulant. The response was regarded as positive when the PAO 30 exceeded the highest basal 30-min acid output [4,5]. The time for the appearance of the acid response refers to the first 15-min period after injection of the stimulant during which the acid output exceeded the highest 15-min output during basal conditions.…”

Vagal regeneration after parietal cell vagotomy: An experimental study in dogs

“…Acid was titrated against 0.1 NaOH with phenol red as an indicator and expressed as mEq/15 minutes. We regard the insulin test as positive if blood glucose once fell below 40 mg/ml; then both criteria according to Hollander and to Emits and Borg were positive [21,22].…”