Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis

Lindsley, Andrew; Li, Wei; Wang, Jian; Maeda, Nana; Rogers, Rhonda; Conway, Simon J.

doi:10.1016/j.modgep.2005.03.005

Cited by 39 publications

(48 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, ECM molecules and their receptors have been implicated in Schwann cell development and function (Chernousov et al, 2008), as well as migration (Chernousov et al, 2001;Milner et al, 1997). The ECM protein periostin, which exhibited the most significant differential expression in our microarray analysis, is expressed in a variety of tissues during development, including DRG and Schwann cell precursors, as shown by us and others (Kruzynska-Frejtag et al, 2001;Lindsley et al, 2005). So far, several isoforms of periostin with varying domain compositions in the C-terminus, generated through alternative splicing, have been reported (Horiuchi et al, 1999;Litvin et al, 2004;Ozdemir et al, 2014).…”

Section: Discussionsupporting

confidence: 64%

Promotion of periostin expression contributes to the migration of Schwann cells

Sonnenberg-Riethmacher

Miehe

Riethmacher

2015

Journal of Cell Science

View full text Add to dashboard Cite

Neuregulin ligands and their ErbB receptors are important for the development of Schwann cells, the glial cells of the peripheral nervous system (PNS). ErbB3 deficiency is characterized by a complete loss of Schwann cells along axons of the peripheral nerves, impaired fasciculation and neuronal cell death. We performed comparative gene expression analysis of dorsal root ganglia (DRG) explant cultures from ErbB3-deficient and wild-type mice in order to identify genes that are involved in Schwann cell development and migration. The extracellular matrix (ECM) gene periostin was found to exhibit the most prominent down regulation in ErbB3-deficient DRG. Expression analysis revealed that the periostin-expressing cell population in the PNS corresponds to Schwann cell precursors and Schwann cells, and is particularly high in migratory Schwann cells. Furthermore, stimulation of Schwann cells with neuregulin-1 (NRG1) or transforming growth factor β (TGFβ-1) resulted in an upregulation of periostin expression. Interestingly, DRG explant cultures of periostindeficient mice revealed a significant reduction of the number of migrating Schwann cells. These data demonstrate that the expression of periostin is stimulated by ErbB ligand NRG1 and influences the migration of Schwann cell precursors.

show abstract

Section: Discussionsupporting

confidence: 64%

Promotion of periostin expression contributes to the migration of Schwann cells

Sonnenberg-Riethmacher

Miehe

Riethmacher

2015

Journal of Cell Science

View full text Add to dashboard Cite

show abstract

“…3A), size, or weight (n ϭ 29; 2-day-old ϩ/ϩ mice were 3.34 Ϯ 0. 1E and F) revealed that they were also indistinguishable between the heterozygous and null mice in utero and that they recapitulated the patterns for endogenous mRNA expression (4,17). Furthermore, histopathologic examination of cardiac valves, teeth, umbilical vessels, placenta, and periosteum around the skeletal elements (the major in utero sites of periostin expression) did not reveal any morphological abnormalities (data not shown).…”

Section: Resultsmentioning

confidence: 64%

“…We also sought to clarify if the developmentally suggestive spatiotemporal regulation of periostin expression is actually required for tooth and heart morphogenesis. We have previously shown that periostin is a useful marker of mesenchymal cells that have undergone epithelial-mesenchymal transformation in the developing heart and is expressed in areas that divide the primitive heart tube into a four-chamber heart (15,17). Additionally, periostin expression remains in the adult valves (15).…”

mentioning

confidence: 99%

periostin Null Mice Exhibit Dwarfism, Incisor Enamel Defects, and an Early-Onset Periodontal Disease-Like Phenotype

Ríos

Koushik

Wang

et al. 2005

Molecular and Cellular Biology

Self Cite

345

430

View full text Add to dashboard Cite

Periostin was originally identified as an osteoblast-specific factor and is highly expressed in the embryonic periosteum, cardiac valves, placenta, and periodontal ligament as well as in many adult cancerous tissues. To investigate its role during development, we generated mice that lack the periostin gene and replaced the translation start site and first exon with a lacZ reporter gene. Surprisingly, although periostin is widely expressed in many developing organs, periostin-deficient (peri lacZ ) embryos are grossly normal. Postnatally, however, ϳ14% of the nulls die before weaning and all of the remaining peri lacZ nulls are severely growth retarded. Skeletal analysis revealed that trabecular bone in adult homozygous skeletons was sparse, but overall bone growth was unaffected. Furthermore, by 3 months, the nulls develop an early-onset periodontal disease-like phenotype. Unexpectedly, these mice also show a severe incisor enamel defect, although there is no apparent change in ameloblast differentiation. Significantly, placing the peri lacZ nulls on a soft diet that alleviated mechanical strain on the periodontal ligament resulted in a partial rescue of both the enamel and periodontal disease-like phenotypes. Combined, these data suggest that a healthy periodontal ligament is required for normal amelogenesis and that periostin is critically required for maintenance of the integrity of the periodontal ligament in response to mechanical stresses.

show abstract

“…It has also been reported in mice in specialized tissues such as corneal and lens epithelium, mesenchymal cells of heart valves, ependymal cells lining the ventricles of the brain, and in prismatic epithelial cells covering the renal papillae [158,159]. The human gene, located on chromosome 12q23.3, is 180.2 kb, contains 69 exons and encodes a 2551 amino acid type I receptor ( Figure 2).…”

Section: Hyaluronic Acid Receptor For Endocytosismentioning

confidence: 91%

“…These ECM components participate in cell signaling cascades and creating space for cell infiltration that is necessary for cellular differentiation as the organ develops [168][169][170]. A study examining the role of fascilin-containing genes expressed in heart development shows that Stabilin-1, HARE, β-IgH3, and periostin are regulated both spatially and temporally as the heart develops [159,171]. HARE expression is restricted to the postnatal mature valve endothelial cells, an area rich in GAGs.…”

Section: Hare and Developmentmentioning

confidence: 99%