Comparison of the First and Second Waves of Hospitalized Patients With SARS-CoV-2

Budweiser, Stephan; Bas, Sevki; Jörres, Rudolf A.; Engelhardt, Sebastian; Thilo, Christian; Delius, Stefan von; Eckel, Florian; Biller, Uwe; Lenherr, Katharina; Deerberg-Wittram, Jens; Bauer, Andreas

doi:10.3238/arztebl.m2021.0215

Cited by 20 publications

(32 citation statements)

References 5 publications

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“…In total, we thus had data from 155 of 252 patients included in the study (62%). Data on the hospital stay were taken from COVID-DB-project [9,42]. Written informed consent was obtained from all participants attending the inpatient assessment, whereas verbal informed consent was obtained from those contacted via phone.…”

Section: Recruitment For Follow-upmentioning

confidence: 99%

“…The physical examination comprised a complete physical examination according to the standards of Internal Medicine and included the assessment of blood pressure, heart rate and oxygen saturation (SpO 2 ) by pulse oximetry at rest. Data on COVID-19 were taken from previous work [9,42]. The analysis of chest computer tomography (CT) scans was performed by an experienced radiologist following guidelines [46].…”

Section: Assessments At the Study Visit 231 Symptoms Physical Examination And Medical Historymentioning

confidence: 99%

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Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave

Staudt

Jörres

Hinterberger

et al. 2022

European Journal of Internal Medicine

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Background: For a better understanding of the factors underlying the Post-Acute COVID Syndrome, we studied the relationship between symptoms and functional alterations in COVID-19 patients 10 months after hospitalization. Methods: One-hundred-one patients hospitalized between March 1st and June 30th 2020 participated in a followup visit for an assessment of clinical history, comorbidities, lung function, physical capacity and symptoms, including the SGRQ for health-related quality of life, PHQ-9-D for depression, and SOMS-2 J for somatoform disorders. Data were analyzed by univariate comparisons and multiple logistic regression analyses. Results: Median age was 60 years, 42% were female, 76% had at least one comorbidity, the median length of the hospital stay was 8 days, 19% had been on the ICU. The most prevalent symptoms included shortness of breath (49%), fatigue (49%) and cognitive impairment (39%). Signs of major depression (PHQ-9-D ≥ 10) occurred in 28%/2% (p < 0.05) of patients with/without self-reported cognitive impairment, with median total SGRQ score being 25.4/5.3 (p < 0.05). There were associations between shortness of breath and BMI, SGRQ and hemoglobin levels; between fatigue, SGRQ and PHQ-9-D; and between cognitive impairment and PHQ-9-D (p < 0.05 each) but not with lung function or physical capacity. Characteristics of the acute disease were not related to symptoms. Conclusions:The findings demonstrate that 10 months after discharge from a hospital stay due to COVID-19, the percentages of patients with symptoms were high. Symptoms showed a consistent pattern but could not be attributed to altered lung function or physical capacity. Our results suggest a role for alternative etiologies including psychosocial factors.

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Section: Recruitment For Follow-upmentioning

confidence: 99%

Section: Assessments At the Study Visit 231 Symptoms Physical Examination And Medical Historymentioning

confidence: 99%

Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave

Staudt

Jörres

Hinterberger

et al. 2022

European Journal of Internal Medicine

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“…The ICU outcome improved only slightly between the first and second wave (28) while the improvement in COVID-19 therapy certainly depends more on clinical management as transfer to ICU dropped from 30% to 14% (28). Although a positive effect of more frequent use of systemic steroids cannot be excluded another small scale study in Germany found also increased NIV and HFNC use during the second wave leading to an improved outcome (29).…”

Section: Discussionmentioning

confidence: 95%

High Variability of COVID-19 Case Fatality Rate in Germany

Wendtner

2021

SSRN Journal

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During the first wave of the COVID-19 pandemic high case fatality rates (CFR) were noticed.Due to the dire consequences WHO guidelines recommended immediate intubation for patients with dyspnoea which has since been questioned after reviewing the initial clinical outcome.Methods: PCR confirmed infection rates along with mortality data was obtained for all German districts from 27 Jan 2020 until 15 Feb 2021 using official data sources. A moving average CFRt was constructed by dividing disease related deaths two weeks after a given index days by the number of infections two weeks prior to that date. In addition to an international comparison, mortality data between the second and third largest German cities were also compared.Results: Mean CFR is estimated to be 2.92 based on 71.965 fatalities and 2.465.407 cases.

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“…Die Umstellung der Therapiestrategie mit Bevorzugung einer nichtinvasiven Beatmung wurde auch aus einem Verbund von vier bayerischen Kliniken berichtet [8]. Dort lag die Sterblichkeit in der ersten Welle mit 526 eingeschlossenen Patienten allerdings bei rund 26%, in der zweiten Welle mit 618 eingeschlossenen Patienten bei rund 18%.…”

Section: Zusammenfassungunclassified

“…Damit war die Sterblichkeit in der ersten Welle deut-lich gegenüber dem aus Daten der Allgemeinen Ortskrankenkassen (AOK) berichteten Niveau von 21% erhöht [9]. Der in [8] festgestellte Rückgang ist daher womöglich auf eine ungewöhnlich hohe Sterblichkeit in der ersten Welle zurückzuführen, für die spezifische Versorgungsgegebenheiten der vier Kliniken verantwortlich sein können. Erfolge einer Therapieoptimierung lassen sich aus dem Rückgang der Sterblichkeit nicht ableiten.…”

Section: Zusammenfassungunclassified

Behandlungskonzepte und Sterblichkeit bei Covid-19

Stausberg¹

2021

MVF

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Comparison of the First and Second Waves of Hospitalized Patients With SARS-CoV-2

Cited by 20 publications

References 5 publications

Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave

Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave

High Variability of COVID-19 Case Fatality Rate in Germany

Behandlungskonzepte und Sterblichkeit bei Covid-19

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